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    Process for production of eicosapentaenoic acid
    2.
    发明公开
    Process for production of eicosapentaenoic acid 失效
    Verfahren zur Herstellung vonEicosapentaensäure。

    公开(公告)号：EP0273708A2

    公开(公告)日：1988-07-06

    申请号：EP87311372.4

    申请日：1987-12-23

    申请人： SAGAMI CHEMICAL RESEARCH CENTER

    发明人： Yazawa, Kazunaga ,  Araki, Keiko ,  Okazaki, Noriko ,  Numao, Naganori ,  Kondo, Kiyosi

    IPC分类号： C12P7/64 ,  C12N1/20

    CPC分类号： C12P7/6427 ,  C12P7/64 ,  C12P7/6472 ,  C12R1/01 ,  C12R1/38

    摘要： A process for the production of (optionally lipid containing) eicosapentaenoic acid comprises the steps of a) culturing a microorganism capable of producing lipid containing eicosapentaenoic acid belonging to the genus Pseudomonas, Alteromonas and Shewanella, to produce lipid containing eicosapentaenoic acid, and b) recovering the (optionally lipid containing) eicosapentaenoic acid from the cultured product. Microorganisms capable of producing eicosapentaenoic acid belonging to the genera Pseudomonas, Alteromonas and Shewanella are also disclosed.

    摘要翻译： （任选含脂质）二十碳五烯酸的方法包括以下步骤：a）培养能够产生属于假单胞菌属，异黄酮和希瓦氏菌属的含二十碳五烯酸的脂质的微生物，以产生含有二十碳五烯酸的脂质，和b）回收 来自培养产物的（任选含脂质的）二十碳五烯酸。 还公开了能够产生属于假单胞菌属，异黄酮和希瓦氏属的二十碳五烯酸的微生物。

    Use of oxazopyrroloquinolines and pyrroloquinolinequinones for the manufacture of nerve growth factor production accelerators
    3.
    发明公开
    Use of oxazopyrroloquinolines and pyrroloquinolinequinones for the manufacture of nerve growth factor production accelerators 失效
    神经生长因子和组合物神经元变性的治疗和预防生产加速器。

    公开(公告)号：EP0555149A1

    公开(公告)日：1993-08-11

    申请号：EP93400283.3

    申请日：1993-02-04

    申请人： MITSUBISHI GAS CHEMICAL COMPANY, INC. ,  SAGAMI CHEMICAL RESEARCH CENTER

    发明人： Tsuji, Tomoko ,  Yamaguchi, Kohji ,  Kondo, Kiyosi ,  Urakami, Teizi, c/o MITSUBISHI GAS CHEMICAL CO.INC

    IPC分类号： A61K31/47

    CPC分类号： A61K31/4745 ,  A61K31/47

    摘要： Nerve growth factor production accelerating agents containing oxazopyrroloquinolines, pyrroquinolinequinones and/or their esters as active ingredient are provided. As the oxazopyrroloquinolines and their esters exhibit such production accelerating activity, they are suitably utilized for preventing and treating functional disorders of central nervous system, particularly, Alzheimer's dementia, cerebral ischemia and spinal trauma, as well as for functional disorders of peripheral nervous system, particularly, peripheral nervous system trauma and diabetic neurosis. As the pyrroquinolinequinones and their esters exhibit strong nerve growth factor production accelerating activity, they are suitably utilized for preventing and treating functional disorders of peripheral nervous system, particularly, peripheral nervous system trauma, diabetic neurosis, etc.

    摘要翻译： 提供神经生长因子产生促进含oxazopyrroloquinolines，pyrroquinolinequinones和/或它们作为活性成分的酯试剂。 作为oxazopyrroloquinolines和它们的酯表现出寻求产生促进活性，它们被适当地使用用于预防和治疗中枢神经系统，尤其是早老性痴呆，脑缺血和脊柱创伤，以及用于外周神经系统的功能障碍的功能性病症，尤其是 ，周围神经系统创伤和糖尿病性神经症。 作为pyrroquinolinequinones及其酯表现出强的神经生长因子产生促进活性，它们被适当地使用用于预防和治疗外周神经系统，特别是，外周神经系统损伤，糖尿病性神经机能病，等的功能性障碍