公开(公告)号：EP0407588A4

公开(公告)日：1991-05-22

申请号：EP89910209

申请日：1989-09-11

申请人： SAGAMI CHEMICAL RESEARCH CENTER

发明人： HIRAI, KENJI ,  NAKAMURA, KAZUMI ,  FUJITA, ATSUKO

IPC分类号： C07C51/353 ,  C07B61/00 ,  C07C51/347 ,  C07C59/84 ,  C07C59/86 ,  C07C59/88 ,  C07C59/90 ,  C07C63/14 ,  C07C63/33 ,  C07D209/18 ,  C07D317/54 ,  C07D317/60 ,  C07D333/24 ,  C07C59/185 ,  C07C51/41

CPC分类号： C07D333/24 ,  C07C51/347 ,  C07D317/60 ,  C07C63/14 ,  C07C59/84 ,  C07C59/86 ,  C07C59/90 ,  C07C59/88

摘要： The invention relates to a process for producing a 2-oxo-3-aromatic carboxylic acid derivative, which comprises reacting an aromatic pyruvic acid derivative with an electrophilic compound in a protic solvent in the presence of a base. This process can provide in good yields the 2-oxo-3-aromatic carboxylic acid derivatives which can be easily converted to aromatic amino acid derivatives or 2-aromatic alkanoic acid derivatives which are important intermediates for synthesizing medicines, agrochemicals, etc.