公开(公告)号：EP3119878A4

公开(公告)日：2017-08-16

申请号：EP15765802

申请日：2015-03-18

申请人： SANGAMO BIOSCIENCES INC

发明人： FROELICH STEVEN ,  GREGORY PHILIP D ,  ZHANG H STEVE

IPC分类号： C12N5/00 ,  A01N63/00 ,  C12N15/00

CPC分类号： C12N15/63 ,  C12N15/86 ,  C12N2830/60

摘要： The present disclosure is in the field of genome engineering, particularly regulating targeted modification of the genome.

摘要翻译： 本公开内容处于基因组工程领域。

公开(公告)号：EP2820159A4

公开(公告)日：2015-08-26

申请号：EP13755872

申请日：2013-02-28

申请人： SANGAMO BIOSCIENCES INC

发明人： MILLER JEFFREY C ,  REBAR EDWARD J ,  ZHANG H STEVE

IPC分类号： C12Q1/68

CPC分类号： A61K38/1709 ,  C07K14/4703 ,  C07K2319/00 ,  C07K2319/70 ,  C07K2319/71 ,  C07K2319/81 ,  C12N15/907

摘要： Disclosed herein are compositions comprising non-naturally occurring zinc finger domains, fusion proteins comprising these zinc finger domains, polynucleotides encoding these proteins, cells expressing these proteins and pharmaceutical compositions comprising these proteins or polynucleotides as well as methods of modifying an Htt gene using these compositions for treating or preventing Huntington's Disease.

公开(公告)号：EP2461819A4

公开(公告)日：2013-07-31

申请号：EP10806737

申请日：2010-07-28

申请人： SANGAMO BIOSCIENCES INC

发明人： GREGORY PHILIP D ,  REBAR EDWARD J ,  ZHANG H STEVE

IPC分类号： A61K38/16 ,  A61K38/00 ,  A61K48/00 ,  A61P25/28 ,  C07K14/47 ,  C12N15/90

CPC分类号： A61K38/1709 ,  A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C07K2319/00 ,  C07K2319/71 ,  C07K2319/81 ,  C12N15/907

摘要： Disclosed herein are methods and compositions for treating trinucleotide repeat disorders.

公开(公告)号：EP3068905A4

公开(公告)日：2017-07-05

申请号：EP14860665

申请日：2014-11-11

申请人： SANGAMO BIOSCIENCES INC

发明人： ZHANG H STEVE

IPC分类号： C12Q1/68

CPC分类号： A61K38/465 ,  A61K9/0085 ,  A61K38/08 ,  A61K38/10 ,  A61K38/164 ,  A61K48/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/10 ,  C12N2310/20 ,  C12N2320/34 ,  C12N2750/14143 ,  C12Y301/00

摘要： Disclosed herein are methods and compositions for diagnosing, treating or preventing Huntington's Disease.

摘要翻译： 公开了用于诊断，治疗亨廷顿氏病的方法和组合物。

公开(公告)号：EP2997146A4

公开(公告)日：2017-04-26

申请号：EP14797155

申请日：2014-05-15

申请人： SANGAMO BIOSCIENCES INC

发明人： CONWAY ANTHONY ,  COST GREGORY J ,  DEKELVER RUSSELL ,  REBAR EDWARD J ,  REIK ANDREAS ,  URNOV FYODOR ,  WANG JIANBIN ,  ZHANG H STEVE

IPC分类号： C12N15/11

CPC分类号： C12N15/907 ,  C07K2/00 ,  C07K2319/81 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90 ,  C12N15/902 ,  C12N2320/30 ,  C12Y301/21004

摘要： Methods and compositions comprising single guide RNAs targeted to an endogenous mammalian β globin gene (HBB), gamma globin gene (HBG1), B-cell lymphoma/leukemia 11A (BCL11A) gene, Kruppel-like factor 1 (KLF1) gene, CCR5 gene, CXCR4 gene, PPP1R12C (AAVS1) gene, hypoxanthine phosphoribosyltransferase (HPRT) gene, albumin gene, Factor VIII gene, Factor IX gene, Leucine-rich repeat kinase 2 (LRRK2) gene, Hungtingin (Htt) gene, rhodopsin (RHO) gene, Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, surfactant protein B gene (SFTPB), T-cell receptor alpha (TRAC) gene, T-cell receptor beta (TRBC) gene, programmed cell death 1 (PD1) gene, Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) gene, human leukocyte antigen (HLA) A gene, a LMP7 gene, a Transporter associated with Antigen Processing (TAP) gene, tapasin gene (TAPBP), a class II major histocompatibility complex transactivator (CIITA) gene, a dystrophin gene (DMD), a glucocorticoid receptor gene (GR), IL2RG gene or RFX5 for genetic alteration of cells are provided.

摘要翻译： 提供了细胞的遗传改变的方法和组合物。