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1.DELIVERY METHODS AND COMPOSITIONS FOR NUCLEASE-MEDIATED GENOME ENGINEERING IN HEMATOPOIETIC STEM CELLS 有权
标题翻译: VERFAHREN UND ZUSAMMENSETZUNGENFÜRNUKLEASEVERMITTELTES GENOM-ENGINEERING INHÄMOTOPOIETISCHENSTAMMZELLEN公开(公告)号:EP3057432A4
公开(公告)日:2017-04-05
申请号:EP14853797
申请日:2014-10-16
CPC分类号: A61K35/28 , A61K48/00 , A61K2035/124 , C12N5/0647 , C12N15/87 , C12N15/907 , C12N2510/00
摘要: The present disclosure is in the field of genome engineering, particularly targeted modification of the genome of a hematopoietic cell.
摘要翻译: 本公开内容在基因组工程领域,特别是造血细胞基因组的靶向修饰。
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2.TARGETED DISRUPTION OF T CELL RECEPTOR GENES USING ENGINEERED ZINC FINGER PROTEIN NUCLEASES 审中-公开
标题翻译: GEZIELTE DISRUPTION VON T-ZELL REZEPTORGENEN MIT MANIPULIERTEN ZINKFINGER-PROTEINNUKLEASEN公开(公告)号:EP2975942A4
公开(公告)日:2016-11-09
申请号:EP14770870
申请日:2014-03-20
发明人: GREGORY PHILIP D , HOLMES MICHAEL C , PASCHON DAVID , ZHANG LEI , BONINI MARIA CHIARA , GENOVESE PIETRO , MAGNANI ZULMA , MASTAGLIO SARA , NALDINI LUIGI
CPC分类号: A61K35/26 , A61K39/0011 , A61K2039/5156 , A61K2039/5158 , C12N15/87 , C12N2501/515 , C12N2510/00
摘要: Disclosed herein are methods and compositions for modifying TCR genes, using nucleases (zinc finger nucleases or TAL nucleases) to modify TCR genes.
摘要翻译: 本文公开了使用核酸酶(锌指核酸酶或TAL核酸酶)修饰TCR基因来修饰TCR基因的方法和组合物。
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