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    COMPOSITIONS FOR LINKING ZINC FINGER MODULES
    3.
    发明公开
    COMPOSITIONS FOR LINKING ZINC FINGER MODULES 审中-公开
    ZUSAMMENSETZUNGEN ZURVERKNÜPFUNGVON ZINKFINGERMODULEN

    公开(公告)号：EP2566972A4

    公开(公告)日：2014-01-01

    申请号：EP11777690

    申请日：2011-05-02

    申请人： SANGAMO BIOSCIENCES INC

    发明人： PASCHON DAVID ,  REBAR EDWARD J

    IPC分类号： C12P21/06 ,  A61K38/04 ,  C07H21/04 ,  C12N5/00

    CPC分类号： C12N15/62

    摘要： Disclosed herein are compositions for linking DNA binding modules to allow for specific and selective binding to module subsites separated by 1 or more base pairs. Also described are methods of making and using compositions comprising these linkers.

    摘要翻译： 本文公开了用于连接DNA结合模块以允许特定和选择性结合由1个或更多个碱基对分开的模块亚型的组合物。 还描述了制备和使用包含这些接头的组合物的方法。

    COMPOSITIONS FOR LINKING DNA-BINDING DOMAINS AND CLEAVAGE DOMAINS
    5.
    发明公开
    COMPOSITIONS FOR LINKING DNA-BINDING DOMAINS AND CLEAVAGE DOMAINS 审中-公开
    ZUSAMMENSETZUNGEN ZUR VERNETZUNG VON DNA-BINDUNGSDOMÄNENUND-SPALTUNGSDOMÄNEN

    公开(公告)号：EP3039136A4

    公开(公告)日：2017-05-03

    申请号：EP14840079

    申请日：2014-08-28

    申请人： SANGAMO BIOSCIENCES INC

    发明人： PASCHON DAVID ,  ZHANG LEI

    IPC分类号： C12N9/16 ,  C12N9/22 ,  C12N15/01 ,  C12N15/90

    CPC分类号： C12N15/907 ,  C07K2319/81 ,  C12N9/22 ,  C12N15/01 ,  C12N15/62

    摘要： Disclosed herein are compositions for linking DNA-binding domains and cleavage domains to form nucleases, for example nucleases with altered target site separation (gap) preferences as compared to conventional linkers. Also described are fusion proteins comprising these linkers. The disclosure also provides methods of using these fusion proteins and compositions thereof for targeted cleavage of cellular chromatin in a region of interest and/or homologous recombination at a predetermined region of interest in cells. Thus, in one aspect, described herein are amino acid sequences linking a DNA-binding domain to a cleavage domain. The linker may replace one or more residues of the DNA-binding domain and/or cleavage domain.

    摘要翻译： 本文公开了用于连接DNA结合结构域和切割结构域（或切割半结构域）以形成非天然存在的核酸酶的组合物。 还描述了制造和使用包含这些连接体的组合物的方法。