公开(公告)号：EP0900797A4

公开(公告)日：2000-07-19

申请号：EP97919696

申请日：1997-04-25

申请人： SANKYO CO

发明人： KAWAMOTO ISAO ,  MORIMOTO MUNETSUGU ,  ISHIKAWA KATSUYA ,  KOJIMA KATSUHIKO ,  SHIMOJI YASUO ,  OHYA SATOSHI

IPC分类号： A61K31/403 ,  A61P31/04 ,  C07D477/20 ,  C07D487/04 ,  A61K31/40

CPC分类号： C07D477/20

摘要： Constitution: 1-Methylcarbapenem compounds of general formula (I) and pharmacologically acceptable salts and derivatives thereof, wherein R1 is hydrogen or lower alkyl; R2 is hydrogen or lower alkyl; and R3 is hydrogen, lower alkyl, substituted lower alkyl, cycloalkyl or -C(=NH)R4 (wherein R4 is hydrogen, lower alkyl or amino). Effect: these compounds exhibit excellent antibacterial activity and are useful as preventive or therapeutic agents for infectious diseases.

公开(公告)号：EP0882728A4

公开(公告)日：1999-03-24

申请号：EP96942592

申请日：1996-12-20

申请人： SANKYO CO

发明人： KAWAMOTO ISAO ,  SHIMOJI YASUO ,  ISHIKAWA KATSUYA ,  KOJIMA KATSUHIKO ,  YASUDA HIROSHI ,  OHYA SATOSHI ,  UTSUI YUKIO

IPC分类号： C07D477/20 ,  C07D487/04 ,  A61K31/40

CPC分类号： C07D477/20

摘要： Constitution: 1-methylcarbapenem compounds having general formula (1) or pharmacologically acceptable salts thereof wherein R1 represents hydrogen or lower alkyl; R2 represents hydrogen or an ester residue; and A represents substituted propylaminopyrrolidin-1-ylcarbonyl, substituted aminoalkanoylaminopyrrolidin-1-ylcarbonyl, 1-hydroxy-2-(substituted aminoalkylpyrrolidin-1-ylcarbonyl)ethyl, 1-hydroxy-2-(substituted piperazin-1-ylcarbonyl)ethyl, 1-hydroxy-2-(substituted pyrrolidinylaminocarbonyl)ethyl, etc. Effect: because of having excellent antibacterial activities, these 1-methylcarbapenem compounds are efficacious as a preventive or remedy for infectious diseases.