公开(公告)号：EP0900797A4

公开(公告)日：2000-07-19

申请号：EP97919696

申请日：1997-04-25

申请人： SANKYO CO

发明人： KAWAMOTO ISAO ,  MORIMOTO MUNETSUGU ,  ISHIKAWA KATSUYA ,  KOJIMA KATSUHIKO ,  SHIMOJI YASUO ,  OHYA SATOSHI

IPC分类号： A61K31/403 ,  A61P31/04 ,  C07D477/20 ,  C07D487/04 ,  A61K31/40

CPC分类号： C07D477/20

摘要： Constitution: 1-Methylcarbapenem compounds of general formula (I) and pharmacologically acceptable salts and derivatives thereof, wherein R1 is hydrogen or lower alkyl; R2 is hydrogen or lower alkyl; and R3 is hydrogen, lower alkyl, substituted lower alkyl, cycloalkyl or -C(=NH)R4 (wherein R4 is hydrogen, lower alkyl or amino). Effect: these compounds exhibit excellent antibacterial activity and are useful as preventive or therapeutic agents for infectious diseases.

公开(公告)号：EP0882728A4

公开(公告)日：1999-03-24

申请号：EP96942592

申请日：1996-12-20

申请人： SANKYO CO

发明人： KAWAMOTO ISAO ,  SHIMOJI YASUO ,  ISHIKAWA KATSUYA ,  KOJIMA KATSUHIKO ,  YASUDA HIROSHI ,  OHYA SATOSHI ,  UTSUI YUKIO

IPC分类号： C07D477/20 ,  C07D487/04 ,  A61K31/40

CPC分类号： C07D477/20

摘要： Constitution: 1-methylcarbapenem compounds having general formula (1) or pharmacologically acceptable salts thereof wherein R1 represents hydrogen or lower alkyl; R2 represents hydrogen or an ester residue; and A represents substituted propylaminopyrrolidin-1-ylcarbonyl, substituted aminoalkanoylaminopyrrolidin-1-ylcarbonyl, 1-hydroxy-2-(substituted aminoalkylpyrrolidin-1-ylcarbonyl)ethyl, 1-hydroxy-2-(substituted piperazin-1-ylcarbonyl)ethyl, 1-hydroxy-2-(substituted pyrrolidinylaminocarbonyl)ethyl, etc. Effect: because of having excellent antibacterial activities, these 1-methylcarbapenem compounds are efficacious as a preventive or remedy for infectious diseases.

公开(公告)号：EP1209166A4

公开(公告)日：2002-10-09

申请号：EP00953494

申请日：2000-08-18

申请人： SANKYO CO

发明人： HOTODA HITOSHI ,  KANEKO MASAKATSU ,  INUKAI MASATOSHI ,  MURAMATSU YASUNORI ,  UTSUI YUKIO ,  OHYA SATOSHI

IPC分类号： C07H19/067 ,  A61K31/7072 ,  A61P31/04 ,  A61P31/06 ,  A61P31/08 ,  C07H19/06 ,  A61K31/70 ,  C07H19/073

CPC分类号： C07H19/06

摘要： Compounds of general formula (I) or pharmacologically acceptable derivatives or salts thereof; compositions for the prevention or treatment of bacterial infections, containing the compounds, the derivatives or the salts as the active ingredient; use of the same in preparing preventive or therapeutic drugs for bacterial infections; and preventive or therapeutic methods of bacterial infections by administering them to warm-blooded animals in pharmacologically effective doses, wherein R and R are each an optionally substituted, aryl, heterocyclic, alkyl or alkenyl group or the like; R is hydrogen or hydroxyl; and X and X are each oxygen, sulfur, or optionally substituted nitrogen.

公开(公告)号：EP0913151A4

公开(公告)日：2001-01-17

申请号：EP97918382

申请日：1997-05-08

申请人： SANKYO CO

发明人： KAWAMOTO ISAO ,  OHYA SATOSHI ,  UTSUI YUKIO

IPC分类号： A61K31/403 ,  A61K31/40 ,  A61K31/407 ,  A61K31/415 ,  A61K31/4188 ,  A61K31/425 ,  A61K31/427 ,  A61P1/04 ,  A61P31/00 ,  C07D477/04 ,  C07D477/20 ,  C07D487/04

CPC分类号： C07D477/20 ,  A61K31/407 ,  A61K31/4188 ,  A61K31/427 ,  C07D477/04

摘要： 1-Methylcarbapenem derivatives of general formula (I) and pharmacologically acceptable salts and esters thereof, useful as the active ingredient of anti-Helicobacter pylori compositions (such as therapeutic or preventive agents for Helicobacter piloriinfections, particularly the therapeutic agents). In said formula, R1 is (IIa), (IIb), (IIc) or (IId), wherein R2 is hydrogen or alkyl; and R3 is hydrogen or alkyl.