公开(公告)号：EP0676398A3

公开(公告)日：1998-07-01

申请号：EP95302409

申请日：1995-04-11

申请人： SANKYO CO

发明人： FUJITA TAKASHI ,  FUJIMOTO KOICHI ,  YOSHIOKA TAKAO ,  YANAGISAWA HIROAKI ,  FUJIWARA TOSHIHIKO ,  HORIKOSHI HIROYOSHI ,  OGUCHI MINORU ,  WADA KUNIO

IPC分类号： C07D263/44 ,  A61K31/33 ,  A61K31/425 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/36 ,  C07D277/34 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/49

CPC分类号： C07D413/12 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/36 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Compounds of formula (I): [wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrimidinyl group; Y represents an oxygen or sulphur atom; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or
N -hydroxyureidomethyl group; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group; and
m is an integer of from 1 to 5] have hypoglycemic and anti-diabetic activities.

公开(公告)号：EP0641769A4

公开(公告)日：1994-07-13

申请号：EP92912966

申请日：1992-06-30

申请人： SANKYO CO

发明人： ISHIHARA SADAO ,  SAITO FUJIO ,  YOSHIOKA TAKAO ,  KOIKE HIROYUKI ,  MIYAKE SHIGEKI ,  MIZUNO HIROSHI

IPC分类号： A61K31/27 ,  A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/41 ,  A61K31/425 ,  A61K31/426 ,  A61K31/465 ,  A61P9/08 ,  A61P9/10 ,  C07C237/08 ,  C07C237/12 ,  C07C237/20 ,  C07C237/22 ,  C07C237/34 ,  C07C271/22 ,  C07C323/60 ,  C07C327/06 ,  C07C327/16 ,  C07C327/34 ,  C07C329/06 ,  C07D209/18 ,  C07D209/20 ,  C07D213/32 ,  C07D213/81 ,  C07D213/82 ,  C07D213/83 ,  C07D233/54 ,  C07D233/64 ,  C07D277/20 ,  C07D277/30 ,  C07D307/68 ,  C07D309/08 ,  C07D317/38 ,  C07D333/38 ,  C07C327/04

CPC分类号： C07D213/81 ,  C07C237/08 ,  C07C237/20 ,  C07C237/22 ,  C07C271/22 ,  C07C323/60 ,  C07C327/34 ,  C07C329/06 ,  C07D209/18 ,  C07D213/82 ,  C07D213/83 ,  C07D233/64 ,  C07D277/30 ,  C07D317/38

摘要： Constitution: an amino acid derivative represented by the general formula (I): R?1NH-CH(R2¿)-CONH-A-ONO¿2? and a pharmacologically acceptable salt thereof, wherein R?1¿ represents hydrogen, C¿1?-C7 alkanoyl, C1-C6 alkoxycarbonyl, C6-C10 arylcarbonyl, C7-C13 aralkylcarbonyl, C7-C13 aralkyloxycarbonyl, or 5- or 6-membered heteroarylcarbonyl; R?2¿ represents substituted C¿1?-C6 alkyl; and A represents C2-C5 alkylene. Effect: this compound is excellent in a collateral vessel dilator activity and an antianginal activity, and hence useful as an antianginal drug.

公开(公告)号：EP0678511A3

公开(公告)日：1998-06-10

申请号：EP95301922

申请日：1995-03-23

申请人： SANKYO CO

发明人： FUJITA TAKASHI ,  YOSHIOKA TAKAO ,  YANAGISAWA HIROAKI ,  FUJIWARA TOSHIHIKO ,  HORIKOSHI HIROYOSHI ,  OGUCHI MINORU ,  WADA KUNIO ,  FUJIMOTO KOICHI

IPC分类号： A61K31/17 ,  A61K31/41 ,  C07D263/44 ,  C07D271/06 ,  C07D277/34 ,  C07D291/04 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D419/10 ,  C07D413/12 ,  C07D413/14 ,  C07D419/12 ,  C07D419/14

CPC分类号： C07D417/12 ,  C07D277/34 ,  C07D417/14

摘要： Compounds of formula (I): [in which: R and R are each hydrogen or alkyl, or together a group of formula -(CH2)k- in which k is an integer; R is hydrogen, alkyl, alkoxy, halogen or hydroxy; A and B are each hydrogen, alkyl, aralkyl, aliphatic carboxylic acyl, aryl-substituted aliphatic carboxylic acyl, aromatic carboxylic acyl or carbamoyl, or A and B together represent >C=O, >C=S, -C(=O)-C(=O)-, -CH2C(=O)-, -CH2CH2-, -SO2- or -CH2SO2-; X is a group of formula: W-(CH2)m-X - in which W is aryl or heterocyclic, X is a single bond, oxygen, sulphur or >NR in which R is hydrogen, alkyl, aralkyl or aryl, and m is 0 or an integer; Y is a group of formula: -(CH2)n-Y -, in which Y is a single bond, oxygen or sulphur, and n is an integer; Z is a group of formula (i), (ii), (iii), (iv), (v) or (vi): in which R is hydrogen, carboxyalkyl, alkanoyloxyalkyl, cycloalkyl-substituted alkanoyloxyalkyl, cycloalkylcarbonyloxyalkyl, alkoxycarbonyloxyalkyl, cycloalkyl-substituted alkoxycarbonyloxyalkyl or cycloalkyloxycarbonyloxyalkyl group]; and salts, esters and solvates thereof and pro-drugs therefor are useful for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, glucose tolerance insufficiency, insulin resistance and diabetic complications.