公开(公告)号：EP0678511A3

公开(公告)日：1998-06-10

申请号：EP95301922

申请日：1995-03-23

申请人： SANKYO CO

发明人： FUJITA TAKASHI ,  YOSHIOKA TAKAO ,  YANAGISAWA HIROAKI ,  FUJIWARA TOSHIHIKO ,  HORIKOSHI HIROYOSHI ,  OGUCHI MINORU ,  WADA KUNIO ,  FUJIMOTO KOICHI

IPC分类号： A61K31/17 ,  A61K31/41 ,  C07D263/44 ,  C07D271/06 ,  C07D277/34 ,  C07D291/04 ,  C07D413/10 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D419/10 ,  C07D413/12 ,  C07D413/14 ,  C07D419/12 ,  C07D419/14

CPC分类号： C07D417/12 ,  C07D277/34 ,  C07D417/14

摘要： Compounds of formula (I): [in which: R and R are each hydrogen or alkyl, or together a group of formula -(CH2)k- in which k is an integer; R is hydrogen, alkyl, alkoxy, halogen or hydroxy; A and B are each hydrogen, alkyl, aralkyl, aliphatic carboxylic acyl, aryl-substituted aliphatic carboxylic acyl, aromatic carboxylic acyl or carbamoyl, or A and B together represent >C=O, >C=S, -C(=O)-C(=O)-, -CH2C(=O)-, -CH2CH2-, -SO2- or -CH2SO2-; X is a group of formula: W-(CH2)m-X - in which W is aryl or heterocyclic, X is a single bond, oxygen, sulphur or >NR in which R is hydrogen, alkyl, aralkyl or aryl, and m is 0 or an integer; Y is a group of formula: -(CH2)n-Y -, in which Y is a single bond, oxygen or sulphur, and n is an integer; Z is a group of formula (i), (ii), (iii), (iv), (v) or (vi): in which R is hydrogen, carboxyalkyl, alkanoyloxyalkyl, cycloalkyl-substituted alkanoyloxyalkyl, cycloalkylcarbonyloxyalkyl, alkoxycarbonyloxyalkyl, cycloalkyl-substituted alkoxycarbonyloxyalkyl or cycloalkyloxycarbonyloxyalkyl group]; and salts, esters and solvates thereof and pro-drugs therefor are useful for the treatment and/or prophylaxis of a variety of disorders, including one or more of: hyperlipemia, hyperglycemia, obesity, glucose tolerance insufficiency, insulin resistance and diabetic complications.

公开(公告)号：EP1679310A4

公开(公告)日：2008-10-29

申请号：EP04773615

申请日：2004-09-29

申请人： SANKYO CO ,  RENASCIENCE CO LTD

发明人： YANAGISAWA HIROAKI ,  AMEMIYA YOSHIYA ,  KUROKAWA KIYOSHI ,  MIYATA TOSHIO

IPC分类号： C07D257/04 ,  A61K31/41 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K31/5415 ,  A61P3/10 ,  A61P13/12 ,  C07D277/34 ,  C07D401/10 ,  C07D405/12 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04

CPC分类号： C07D277/34 ,  A61K31/41 ,  A61K31/426 ,  A61K31/437 ,  A61K31/4709 ,  A61K31/5377 ,  A61K31/538 ,  A61K31/541 ,  A61K31/5415 ,  C07D257/04 ,  C07D401/10 ,  C07D413/10 ,  C07D417/10 ,  C07D471/04

摘要： Disclosed are a compound represented by the following general formula (I): (I) (wherein A represents a cyclic ring or the like; B represents 1H-tetrazole-5-yl group or 2,4-dioxothiazolidine-5-yl group; and Y represents a single bond or a C6-10 arylene group), or a pharmacologically acceptable salt or ester thereof.

公开(公告)号：EP1026149A4

公开(公告)日：2004-12-01

申请号：EP98945527

申请日：1998-09-30

申请人： SANKYO CO

发明人： YANAGISAWA HIROAKI ,  SAKURAI MITSUYA ,  TAKAMURA MAKOTO ,  FUJIWARA TOSHIHIKO

IPC分类号： A61K31/165 ,  A61K31/42 ,  A61K31/44 ,  A61K31/445 ,  A61K31/47 ,  A61P3/00 ,  C07C233/69 ,  C07C235/42 ,  C07C235/48 ,  C07C235/84 ,  C07C237/32 ,  C07D209/30 ,  C07D213/20 ,  C07D213/64 ,  C07D213/82 ,  C07D215/54 ,  C07D277/42 ,  C07D295/155 ,  C07D413/12

CPC分类号： C07D213/20 ,  C07C233/69 ,  C07C235/42 ,  C07C235/48 ,  C07C235/84 ,  C07C237/32 ,  C07D209/30 ,  C07D213/64 ,  C07D213/82 ,  C07D215/54 ,  C07D295/155 ,  C07D413/12

摘要： Amidocarboxylic acid derivatives represented by general formula (I), pharmacologically acceptable salts thereof, or pharmacologically acceptable esters thereof, wherein R1 represents a hydrogen atom or the like; R2 represents an alkylene group; R3 represents a hydrogen atom or the like; R4 represents a hydrogen atom or the like; X represents a substituted or unsubstituted aryl group or the like; Y represents an oxygen atom or the like; Z represents an alkylene group or the like; and W represents an alkyl group or the like. These compounds are useful as therapeutic and or prophylactic agents for diabetes, hyperlipemia, arterial sclerosis, hypertension and the like.

摘要翻译： 由通式（I）表示的酰胺基羧酸衍生物，其药理学上可接受的盐或其药理学上可接受的酯，其中R1代表氢原子等; R2代表亚烷基; R3代表氢原子等; R4表示氢原子等; X表示取代或未取代的芳基等; Y表示氧原子等; Z表示亚烷基等; W表示烷基等。 这些化合物可用作治疗和/或预防糖尿病，高脂血症，动脉硬化，高血压等的药物。

公开(公告)号：EP0916651A4

公开(公告)日：2001-09-12

申请号：EP97908566

申请日：1997-04-01

申请人： SANKYO CO

发明人： YANAGISAWA HIROAKI ,  TAKAMURA MAKOTO ,  FUJITA TAKASHI ,  FUJIWARA TOSHIHIKO

IPC分类号： C07C251/50 ,  A61K31/15 ,  A61K31/195 ,  A61K31/415 ,  A61P31/10 ,  C07C251/54 ,  C07C251/58 ,  C07C259/02 ,  C07C317/32 ,  C07C323/45 ,  C07C323/62 ,  C07D213/36 ,  C07D213/53 ,  C07D233/61 ,  C07D233/64 ,  C07D277/26 ,  C07D307/52 ,  C07D263/32 ,  C07D263/34 ,  C07D333/22

CPC分类号： C07D213/53 ,  C07C251/54 ,  C07C251/58 ,  C07C323/62

摘要： Phenylalkylcarboxylic acid derivatives represented by general formula (I) and pharmacologically acceptable salts and esters thereof (wherein R1 represents alkyl, etc.; R2 represents alkylene; R3 represents hydrogen, etc.; X represents (un)substituted aryl, etc.; Y represents oxygen, etc.; Z represents alkylene, etc.; and W represents alkyl, etc.), useful as a remedy or preventive for hyperglycemia and the like.

摘要翻译： （I）表示的苯基烷基羧酸衍生物及其药理学上可接受的盐和酯（其中R1表示烷基等; R2表示亚烷基; R3表示氢等; X表示（未）取代的芳基等; Y表示 氧等; Z代表亚烷基等; W代表烷基等），用作治疗或预防高血糖症等。

公开(公告)号：EP0676398A3

公开(公告)日：1998-07-01

申请号：EP95302409

申请日：1995-04-11

申请人： SANKYO CO

发明人： FUJITA TAKASHI ,  FUJIMOTO KOICHI ,  YOSHIOKA TAKAO ,  YANAGISAWA HIROAKI ,  FUJIWARA TOSHIHIKO ,  HORIKOSHI HIROYOSHI ,  OGUCHI MINORU ,  WADA KUNIO

IPC分类号： C07D263/44 ,  A61K31/33 ,  A61K31/425 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/36 ,  C07D277/34 ,  C07D413/10 ,  C07D413/12 ,  C07D417/10 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/49

CPC分类号： C07D413/12 ,  C07D209/08 ,  C07D209/10 ,  C07D209/12 ,  C07D209/36 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04

摘要： Compounds of formula (I): [wherein: X represents an unsubstituted or substituted indolyl, indolinyl, azaindolyl, azaindolinyl, imidazopyridyl or imidazopyrimidinyl group; Y represents an oxygen or sulphur atom; Z represents a 2,4-dioxothiazolidin-5-ylidenylmethyl, 2,4-dioxothiazolidin-5-ylmethyl, 2,4-dioxooxazolidin-5-ylmethyl, 3,5-dioxooxadiazolidin-2-ylmethyl or
N -hydroxyureidomethyl group; R represents a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, a hydroxy group, a nitro group, an aralkyl group or a unsubstituted or substituted amino group; and
m is an integer of from 1 to 5] have hypoglycemic and anti-diabetic activities.