公开(公告)号：EP2580224A1

公开(公告)日：2013-04-17

申请号：EP11729738.2

申请日：2011-06-10

申请人： SANOFI

发明人： FEREY, Vincent ,  MATEOS-CARO, Julia ,  MONDIERE, Régis ,  VAYRON, Philippe ,  VIGNE, Sylvie

IPC分类号： C07F17/02

CPC分类号： C07F17/02

摘要： The invention relates to a method of synthesis of ferroquine of formula (F) or of its metabolite of formula (Fm): comprising a reaction of reductive amination, said reaction comprising: (i) a stage of condensation of the aldhehyde-amino ferrocene of formula (1 ), which R represents a hydrogen atom or a methyl group, with the 7-chloroquinolin- amine of formula (2) as shown below, followed by (ii) a stage of reduction of the product of condensation obtained in the preceding stage (iii) then a stage of hydrolysis of the reaction mixture in the presence of an aqueous solution of ammonia or of citric acid.

公开(公告)号：EP2580224B1

公开(公告)日：2014-05-28

申请号：EP11729738.2

申请日：2011-06-10

申请人： SANOFI

发明人： FEREY, Vincent ,  MATEOS-CARO, Julia ,  MONDIERE, Régis ,  VAYRON, Philippe ,  VIGNE, Sylvie

IPC分类号： C07F17/02

CPC分类号： C07F17/02