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1.发明授权DERIVE DE METHANESULFONAMIDO-BENZOFURANE, SON PROCEDE DE PREPARATION ET SON UTILISATION COMME INTERMEDIAIRE DE SYNTHESE 有权METHANSUFONAMIDO苯并呋喃，方法和其作为合成中间体
公开(公告)号：EP1343777B1
公开(公告)日：2004-05-06
申请号：EP01270534.9
申请日：2001-12-10
申请人： SANOFI-SYNTHELABO
发明人： FINO, Noel , LEROY, Corinne
IPC分类号： C07D307/79 , C07D307/80
CPC分类号： C07D307/79 , C07D307/80
摘要： The invention concerns 2-butyl-5-methanesulphonamido-benzofuran, its preparation and its use. Said compound is a synthesis intermediate in particular for preparing dronedarone.
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公开(公告)号：EP2552900A1
公开(公告)日：2013-02-06
申请号：EP11718443.2
申请日：2011-03-31
申请人： SANOFI
发明人： BON, Xavier , LEROY, Corinne
IPC分类号： C07D307/81 , C07D307/80 , C07D307/79 , C07C233/54 , C07C233/33
CPC分类号： C07D307/79 , C07D307/80 , C07D307/81
摘要： The invention relates to a process for preparing 5-aminobenzofuran derivatives of general formula: Formula (I), in which R
1 is hydrogen or an alkyl group and R
2 is an alkyl or dialkylaminoalkyl group. According to the invention, the compounds of formula (I) are prepared by treating a 5‑N‑alkylamidobenzofuran derivative of general formula: in which R
1 and R
2 have the same meaning as above and R
3 is an alkyl group, with a strong acid, so as to form an acid addition salt of the compound of formula (I), which salt is itself treated, if necessary, with a basic agent so as to form this compound of formula (I) in free base form.-
公开(公告)号：EP2595976A1
公开(公告)日：2013-05-29
申请号：EP11754698.6
申请日：2011-07-18
申请人： SANOFI
IPC分类号： C07D307/80
CPC分类号： A61K31/343 , C07D307/80
摘要： The invention relates to a process for preparing 5-aminobenzoylbenzofuran derivatives of formula (I), in which R
1 represents hydrogen or an alkyl group and R
2 represents hydrogen, an alkyl, alkoxy or dialkylaminoalkoxy group, by reduction of a 5-nitrobenzofuran derivative of formula (II) using a hydrogen transfer agent, in the presence of palladium-on-charcoal as catalyst and in an ether or an ether mixture as solvent.摘要翻译： 本发明涉及制备式（I）的5-氨基苯甲酰基苯并呋喃衍生物的方法，其中R 1表示氢或烷基，R 2表示氢，烷基，烷氧基或二烷基氨基烷氧基，通过还原5-硝基苯并呋喃衍生物 使用氢转移剂，在作为催化剂的钯 - 炭的存在下和作为溶剂的醚或醚混合物中进行。
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4.发明公开DERIVE DE METHANESULFONAMIDO-BENZOFURANE, SON PROCEDE DE PREPARATION ET SON UTILISATION COMME INTERMEDIAIRE DE SYNTHESE 有权METHANSUFONAMIDO苯并呋喃，方法和其作为合成中间体
公开(公告)号：EP1343777A1
公开(公告)日：2003-09-17
申请号：EP01270534.9
申请日：2001-12-10
申请人： SANOFI-SYNTHELABO
发明人： FINO, No[l , LEROY, Corinne
IPC分类号： C07D307/79 , C07D307/80
CPC分类号： C07D307/79 , C07D307/80
摘要： The invention concerns 2-butyl-5-methanesulphonamido-benzofuran, its preparation and its use. Said compound is a synthesis intermediate in particular for preparing dronedarone.
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