公开(公告)号：EP3319986A1

公开(公告)日：2018-05-16

申请号：EP16736427.2

申请日：2016-07-06

申请人： SANOFI

发明人： CORVEY, Carsten ,  STUMP, Heike ,  KRUIP, Jochen ,  LANGE, Christian ,  FOCKEN, Ingo ,  RAT, Dorothea ,  STUEDEMANN, Thomas ,  RASSER, Hans-Falk ,  SCHAEFER, Juergen ,  CALANDRA, Bernhard ,  REY, Astrid ,  MOUREZ, Michael ,  FRAISSE, Laurent ,  ROTHE, Christine ,  ALLERSDORFER, Andrea ,  WIEDENMANN, Alexander ,  HINNER, Marlon ,  LUNDE, Bradley ,  JENSEN, Kristian ,  HÜLSMEYER, Martin

IPC分类号： C07K14/47

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/22 ,  C07K2319/30 ,  C07K2319/50 ,  C07K2319/70

摘要： The present invention relates to fusion molecules that have binding specificity for pyoverdine type I, II and III and pyochelin and can be used in various applications, including diagnostic and/or therapeutic applications, for example, to inhibit or reduce growth of P. aeruginosa and/or to prevent or treat P. aeruginosa biofilm infection as well as diseases or disorders associated with P. aeruginosa biofilm infection. The present invention also concerns methods of producing the fusion molecules described herein as well as compositions and kits comprising such fusion molecules. The present invention further relates to nucleic acid molecules encoding the fusion molecules described herein.

公开(公告)号：EP3259282A1

公开(公告)日：2017-12-27

申请号：EP16704641.6

申请日：2016-02-16

申请人： SANOFI

发明人： CORVEY, Carsten ,  STUMP, Heike ,  KRUIP, Jochen ,  CALANDRA, Bernhard ,  REY, Astrid ,  KARST, Nathalie ,  MOUREZ, Michael ,  FRAISSE, Laurent ,  ROTHE, Christine ,  ALLERSDORFER, Andrea ,  WIEDENMANN, Alexander ,  HINNER, Marlon ,  LUNDE, Bradley ,  JENSEN, Kristian ,  HÜLSMEYER, Martin

IPC分类号： C07K14/47 ,  A61K38/00 ,  A61K38/17

CPC分类号： C07K14/4703 ,  A61K38/00 ,  A61K38/005 ,  A61K38/012 ,  C07K14/47

摘要： The present disclosure provides hNGAL muteins that bind a pyoverdine family member or pyochelin and can be used in various application including pharmaceutical applications, for example, to inhibit or reduce growth of P. aeruginosa. The present disclosure also concerns methods of making one or more pyoverdine- or pyochelin-binding muteins described herein as well as compositions comprising one or more of such muteins. The present disclosure further relates to nucleic acid molecules encoding such muteins and to methods for generation of such muteins and nucleic acid molecules. In addition, the application discloses therapeutic and/or diagnostic uses of these muteins as well as compositions comprising one or more of such muteins.