公开(公告)号：EP0817621B1

公开(公告)日：2001-06-20

申请号：EP96911002.2

申请日：1996-03-29

申请人： SANOFI-SYNTHELABO

发明人： SAUNAL, Henry ,  ILLEL, Brigitte

IPC分类号： A61K9/70

CPC分类号： A61K9/2866 ,  A61K9/2846 ,  A61K9/2886 ,  A61K9/7015 ,  A61K31/551 ,  Y10S514/947 ,  Y10S602/904

公开(公告)号：EP0772474B1

公开(公告)日：1998-05-20

申请号：EP95926422.7

申请日：1995-07-25

申请人： ELF AQUITAINE ,  SANOFI

发明人： MULLER, Daniel ,  SAUNAL, Henry

IPC分类号： A61N1/30

CPC分类号： A61N1/0436

摘要： An iontophoresis device in which at least one of the electrodes is a composite electrode containing a polymeric binder, a powdered or fibrous conductive filler and a divided material capable of being consumed by electrochemical oxidation or reduction. The binder of the composite electrode consists of a polymer containing 60-100 mol % of 1,2-epoxypropane and/or 1,2-epoxybutane, and 40-0 mol % of at least one other monomer that is copolymerisable with such oxides. The device is useful for transcutaneously delivering active principles to a patient.

公开(公告)号：EP1919473A1

公开(公告)日：2008-05-14

申请号：EP06794228.4

申请日：2006-07-27

申请人： Sanofi-Aventis

发明人： CUINE, Alain ,  DECOBERT, Michel ,  FRANCON, Dominique ,  SAUNAL, Henry

IPC分类号： A61K31/437 ,  A61K31/15 ,  A61P25/00 ,  A61P43/00

CPC分类号： A61K31/15 ,  A61K31/437 ,  A61K2300/00

摘要： The invention relates to the combination of: a short-acting hypnotic agent which is selected from among a modulator of receptors GABA-A, a benzodiazepine, a phenothiazine, a melatonin derivative and a melatonin receptor agonist; and a long-acting hypnotic agent which is selected from among a modulator of receptors GABA-A, a benzodiazepine, an antagonist of receptors 5HT2A and a calcium ion modulator, for the treatment of sleep disorders. The invention also relates to galenic formulations containing said combination.

公开(公告)号：EP1049542A1

公开(公告)日：2000-11-08

申请号：EP99900981.4

申请日：1999-01-22

申请人： SANOFI-SYNTHELABO

发明人： CASSIER, Daniel ,  ILLEL, Brigitte ,  SAUNAL, Henry

IPC分类号： B05B11/00 ,  B05B15/08

CPC分类号： B05B11/309 ,  B05B11/3052 ,  B05B15/68

摘要： The invention concerns a sprayer (12) actuating device comprising a support (22) whereon the sprayer (12) is supported and a member (24) actuating the sprayer knob (18) mobile axially relative to the support by the action of the control means (34, 36, 43, 46, 47, 58) between a position driving in the knob (18) and a position releasing it, the control means (34, 36, 43, 47 58) comprising elastic means (36) for urging the actuating member in depressing position and means capable of disengaging (58) the lock of the actuating member into releasing position. The control means comprise a rotatable handle (43) manually actuated by a user and associated to a cam (43) moving the actuating member (24) from the depressing position to the releasing position.

公开(公告)号：EP0805706B1

公开(公告)日：2000-05-10

申请号：EP96901841.5

申请日：1996-01-24

申请人： SANOFI ,  ELF AQUITAINE ,  Akzo Nobel N.V.

发明人： MULLER, Daniel ,  BARBIER, Alain ,  SAUNAL, Henry

IPC分类号： A61N1/30

CPC分类号： A61N1/0436 ,  A61N1/044

摘要： A device comprising a reversible negative electrode in contact with a reservoir element containing an electrolyte which contains an active principle such as an anionic oligosaccharide, particularly a pentasaccharide, in at least partially ionised form, a positive electrode alone or in combination with an electrolyte-containing receptacle, and an electrical signal generator connectable to both electrodes. The generator is arranged to apply electrical signals between the electrodes, which signals have an average voltage such that the average current density generated between the electrodes is 0.05-0.25 mA/cm . The amount of active principle in the reservoir element combined with the negative electrode is 0.5-12 mg per cm of the electrode and per mAh of current through 1 cm of the electrode.

公开(公告)号：EP0817621B2

公开(公告)日：2007-12-26

申请号：EP96911002.2

申请日：1996-03-29

申请人： Sanofi-Aventis

发明人： SAUNAL, Henry ,  ILLEL, Brigitte

IPC分类号： A61K9/70

CPC分类号： A61K9/2866 ,  A61K9/2846 ,  A61K9/2886 ,  A61K9/7015 ,  A61K31/551 ,  Y10S514/947 ,  Y10S602/904

摘要： A pharmaceutical composition for transdermal delivery including (a) optionally a polymeric release matrix capable of forming a flexible film when dried, said matrix being selected from cellulose polymers or copolymers and vinylpyrrolidone/vinyl acetate copolymers, (b) an active principle, (c) a transcutaneous absorption promoter for the active principle, and (d) a physiologically acceptable non-aqueous solvent capable of dissolving the release matrix, the active principle and the transcutaneous absorption promoter, and quickly removing same by evaporation on contact with the skin.

公开(公告)号：EP0817621A1

公开(公告)日：1998-01-14

申请号：EP96911002.0

申请日：1996-03-29

申请人： SANOFI

发明人： SAUNAL, Henry ,  ILLEL, Brigitte

IPC分类号： A61P25 ,  A61K9 ,  A61K31 ,  A61K47

CPC分类号： A61K9/2866 ,  A61K9/2846 ,  A61K9/2886 ,  A61K9/7015 ,  A61K31/551 ,  Y10S514/947 ,  Y10S602/904

摘要： A pharmaceutical composition for transdermal delivery including (a) optionally a polymeric release matrix capable of forming a flexible film when dried, said matrix being selected from cellulose polymers or copolymers and vinylpyrrolidone/vinyl acetate copolymers, (b) an active principle, (c) a transcutaneous absorption promoter for the active principle, and (d) a physiologically acceptable non-aqueous solvent capable of dissolving the release matrix, the active principle and the transcutaneous absorption promoter, and quickly removing same by evaporation on contact with the skin.

公开(公告)号：EP0805706A1

公开(公告)日：1997-11-12

申请号：EP96901841.0

申请日：1996-01-24

申请人： SANOFI ,  ELF AQUITAINE ,  Akzo Nobel N.V.

发明人： MULLER, Daniel ,  BARBIER, Alain ,  SAUNAL, Henry

IPC分类号： A61N1

CPC分类号： A61N1/0436 ,  A61N1/044

摘要： A device comprising a reversible negative electrode in contact with a reservoir element containing an electrolyte which contains an active principle such as an anionic oligosaccharide, particularly a pentasaccharide, in at least partially ionised form, a positive electrode alone or in combination with an electrolyte-containing receptacle, and an electrical signal generator connectable to both electrodes. The generator is arranged to apply electrical signals between the electrodes, which signals have an average voltage such that the average current density generated between the electrodes is 0.05-0.25 mA/cm2. The amount of active principle in the reservoir element combined with the negative electrode is 0.5-12 mg per cm2 of the electrode and per mAh of current through 1 cm2 of the electrode.

公开(公告)号：EP1919473B1

公开(公告)日：2012-12-05

申请号：EP06794228.4

申请日：2006-07-27

申请人： SANOFI

发明人： CUINE, Alain ,  DECOBERT, Michel ,  FRANCON, Dominique ,  SAUNAL, Henry

IPC分类号： A61K31/437 ,  A61K31/15 ,  A61P25/00 ,  A61P43/00

CPC分类号： A61K31/15 ,  A61K31/437 ,  A61K2300/00

公开(公告)号：EP1049542B1

公开(公告)日：2004-01-07

申请号：EP99900981.4

申请日：1999-01-22

申请人： SANOFI-SYNTHELABO

发明人： CASSIER, Daniel ,  ILLEL, Brigitte ,  SAUNAL, Henry

IPC分类号： B05B11/00 ,  B05B15/08

CPC分类号： B05B11/309 ,  B05B11/3052 ,  B05B15/68

摘要： The invention concerns a sprayer (12) actuating device comprising a support (22) whereon the sprayer (12) is supported and a member (24) actuating the sprayer knob (18) mobile axially relative to the support by the action of the control means (34, 36, 43, 46, 47, 58) between a position driving in the knob (18) and a position releasing it, the control means (34, 36, 43, 47 58) comprising elastic means (36) for urging the actuating member in depressing position and means capable of disengaging (58) the lock of the actuating member into releasing position. The control means comprise a rotatable handle (43) manually actuated by a user and associated to a cam (43) moving the actuating member (24) from the depressing position to the releasing position.