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1.发明公开EXTRACELLULAR ALLOSTERIC INHIBITOR BINDING DOMAIN FROM A TYROSINE KINASE RECEPTOR 有权Ext re che che che che or or or or or or or or or or or or or or
公开(公告)号：EP2448964A1
公开(公告)日：2012-05-09
申请号：EP10734333.7
申请日：2010-07-02
发明人： CARMELIET, Peter , DE SMET, Frederik , SCHYMKOWITZ, Joost , ROUSSEAU, Frédéric , HERBERT, Corentin
IPC分类号： C07K14/71 , A61K31/4745
CPC分类号： A61K31/437 , C07K14/71 , G01N2500/02
摘要： The present invention relates to an extracellular binding domain for an allosteric inhibitor, whereby said binding domain is derived from a single membrane span tyrosine kinase receptor. More specifically, the invention relates to an extracellular domain derived from a Fibroblast Growth Factor Receptor (FGFR). It further relates to the use of this domain for the identification of similar domains in the extracellular part of other tyrosine kinase receptors, and to a screening method for identification of a small compound allosteric inhibitor.
摘要翻译： 本发明涉及变构抑制剂的细胞外结合结构域，其中所述结合结构域衍生自单个跨膜酪氨酸激酶受体。 更具体地，本发明涉及来自成纤维细胞生长因子受体（FGFR）的细胞外结构域。 它进一步涉及该领域用于鉴定其它酪氨酸激酶受体细胞外部分中类似结构域的用途，以及用于鉴定变构抑制剂的筛选方法。
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2.发明授权EXTRACELLULAR ALLOSTERIC INHIBITOR BINDING DOMAIN FROM A TYROSINE KINASE RECEPTOR 有权酪氨酸激酶受体的胞外变构抑制剂结合域
公开(公告)号：EP2448964B1
公开(公告)日：2017-04-12
申请号：EP10734333.7
申请日：2010-07-02
发明人： CARMELIET, Peter , DE SMET, Frederik , SCHYMKOWITZ, Joost , ROUSSEAU, Frédéric , HERBERT, Corentin
IPC分类号： C07K14/71 , A61K31/4745
CPC分类号： A61K31/437 , C07K14/71 , G01N2500/02
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3.发明授权METHODS FOR SCREENING INHIBITORS OF TUMOUR ASSOCIATED PROTEIN AGGREGATION. 有权一种筛选抑制剂AGGREGREGIERUNG癌症相关的蛋白质
公开(公告)号：EP2689247B1
公开(公告)日：2016-10-05
申请号：EP12710284.6
申请日：2012-03-26
IPC分类号： G01N33/50
CPC分类号： G01N33/5008 , C12Q1/68 , G01N33/5011 , G01N2333/4748 , G01N2500/10
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4.发明公开METHODS FOR SCREENING INHIBITORS OF TUMOUR ASSOCIATED PROTEIN AGGREGATION 有权一种筛选抑制剂AGGREGREGIERUNG癌症相关的蛋白质
公开(公告)号：EP2689247A1
公开(公告)日：2014-01-29
申请号：EP12710284.6
申请日：2012-03-26
IPC分类号： G01N33/50
CPC分类号： G01N33/5008 , C12Q1/68 , G01N33/5011 , G01N2333/4748 , G01N2500/10
摘要： The present invention relates to the fields of protein aggregation diseases including cancer. More specifically, it concerns a screening method for identifying compounds that inhibit or disrupt co-aggregation of one or more member proteins of a disease-related protein aggregome, in particular a tumor-associated protein aggregome. Further, the invention encompasses agents and compounds identified by the screening method which can be applied to prevent or to treat protein aggregation diseases, such as cancer.
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公开(公告)号：EP2839001B1
公开(公告)日：2017-09-06
申请号：EP13716802.7
申请日：2013-04-18
发明人： ROUSSEAU, Frederic , SCHYMKOWITZ, Joost , GANESAN, Ashok , SIEKIERSKA, Aleksandra , DE SMET, Frederik , VAN DURME, Joost
CPC分类号： C12N9/2465 , C07K14/32 , C07K14/43595 , C40B30/02 , G06F19/16
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6.发明公开MEANS AND METHODS FOR GENERATING IMPROVED PROTEINS 有权MITTEL UND VERFAHREN ZUR ERZEUGUNG VERBESSERTER PROTEINE
公开(公告)号：EP2839001A1
公开(公告)日：2015-02-25
申请号：EP13716802.7
申请日：2013-04-18
发明人： ROUSSEAU, Frederic , SCHYMKOWITZ, Joost , GANESAN, Ashok , SIEKIERSKA, Aleksandra , DE SMET, Frederik , VAN DURME, Joost
CPC分类号： C12N9/2465 , C07K14/32 , C07K14/43595 , C40B30/02 , G06F19/16
摘要： The present invention provides a general method for the production of protein variants with a reduced aggregation propensity without affecting the thermodynamic stability of the variant with respect to the wild type protein.
摘要翻译： 本公开提供了生产具有降低的聚集倾向的蛋白质变体的一般方法，而不影响变体相对于野生型蛋白质的热力学稳定性。
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