公开(公告)号：EP1226135A2

公开(公告)日：2002-07-31

申请号：EP00969645.1

申请日：2000-10-19

申请人： SANOFI-SYNTHELABO

发明人： BIARD, Michel ,  BOUSQUET, André

IPC分类号： C07D333/16

CPC分类号： C07D333/16

摘要： The invention concerns a method for preparing 2-thienyl-2-ethanol which consists in: (a) metallation of thiophene using an alkali metal in the presence of an electron-transferring agent; (b) treating the resulting compound with ethylene oxide; (c) hydrolyzing the resulting thienyl derivative, thereby obtaining the desired compound. 2-thienyl-2-ethanol is a synthesis intermediate.

公开(公告)号：EP1032557B1

公开(公告)日：2003-09-10

申请号：EP98954537.1

申请日：1998-11-09

申请人： SANOFI-SYNTHELABO

发明人： BIARD, Michel ,  CASTRO, Bertrand

IPC分类号： C07C253/30 ,  C07C255/50

CPC分类号： C07C253/30 ,  Y02P20/55 ,  C07C255/50

摘要： The invention concerns a method for preparing 4'-bromomethyl-biphenyl derivatives of general formula (I) in which R is as defined in Claim 1, characterised in that it consists in reacting in a biphasic medium and under the effect of light irradiation, a bromination agent selected among bromine, N-bromoacetamide, N-bromophtalimide, N-bromomaleimide, a N-bromosulphonamide, N-bromosuccinimide, 1,3-dibromo-5,5-dimehtylhydantoin and an alkaline metal bromhydric/bromate acid system with a biphenyl derivative of general formula (II) in which R has the same meaning as above, thereby obtaining the desired compound.

公开(公告)号：EP1351907A1

公开(公告)日：2003-10-15

申请号：EP01270513.3

申请日：2001-12-10

申请人： SANOFI-SYNTHELABO

发明人： BIARD, Michel

IPC分类号： C07C15/107 ,  C07D307/80

CPC分类号： C07D307/80 ,  C07C217/22

摘要： The invention concerns 2-butyl-3-(4-[3(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran hydrochloride, its preparation and its use as synthesis intermediate in particular for preparing 2-butyl-3-(4-[3-(dibutylamino)propoxy]benzoyl)-5-nitro-benzofuran which is itself intermediate for dronedarone.