PROCEDE DE PREPARATION D'UN DERIVE DU THIOPHENE
    1.
    发明公开
    PROCEDE DE PREPARATION D'UN DERIVE DU THIOPHENE 有权
    用于生产的噻吩衍生物

    公开(公告)号:EP1226135A2

    公开(公告)日:2002-07-31

    申请号:EP00969645.1

    申请日:2000-10-19

    申请人: SANOFI-SYNTHELABO

    IPC分类号: C07D333/16

    CPC分类号: C07D333/16

    摘要: The invention concerns a method for preparing 2-thienyl-2-ethanol which consists in: (a) metallation of thiophene using an alkali metal in the presence of an electron-transferring agent; (b) treating the resulting compound with ethylene oxide; (c) hydrolyzing the resulting thienyl derivative, thereby obtaining the desired compound. 2-thienyl-2-ethanol is a synthesis intermediate.