公开(公告)号：EP1419150A2

公开(公告)日：2004-05-19

申请号：EP02774822.7

申请日：2002-07-15

申请人： SANOFI-SYNTHELABO

发明人： DI MALTA, Alain ,  GARCIA, Georges ,  ROUX, Richard ,  SCHOENTJES, Bruno ,  SERRADEIL-LE GAL, Claudine ,  TONNERRE, Bernard ,  WAGNON, Jean

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  A61K31/496 ,  A61P13/00

CPC分类号： C07D401/12 ,  C07D401/14 ,  C07D403/12

摘要： The invention concerns compounds of formula (I), as well as their addition salts with acids or organic salts, their solvates and/or hydrate(s), exhibiting affinity and selectivity for arginine-vasopressin V1b receptors and/or for ocytocin receptors, and further, for certain compounds an affinity for V1a receptors. The invention also concerns the method for preparing them, intermediate compounds of formula (IV) useful for their preparation, pharmaceutical compositions containing them and their use for preparing medicines.

公开(公告)号：EP1255751A2

公开(公告)日：2002-11-13

申请号：EP01907685.0

申请日：2001-01-24

申请人： SANOFI-SYNTHELABO

发明人： ROUX, Richard ,  SERRADEIL-LE GAL, Claudine ,  TONNERRE, Bernard ,  WAGNON, Jean

IPC分类号： C07D403/04 ,  A61K31/404 ,  A61P43/00 ,  C07D405/14

CPC分类号： C07D403/04 ,  A61K31/405 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541

摘要： The invention concerns compounds of formula (I) and their possible salts with mineral or organic acids, their solvates and/or hydrates, having affinity and selectivity for V1b receptor or for both V1b and V1a arginine-vasopressin receptors. The invention also concerns their preparation method, intermediate compounds of formula (II) used in their preparation, pharmaceutical compositions containing them for use in preparing medicines.

公开(公告)号：EP1259505B1

公开(公告)日：2004-05-19

申请号：EP01907866.6

申请日：2001-02-22

申请人： SANOFI-SYNTHELABO

发明人： SERRADEIL-LE GAL, Claudine ,  TONNERRE, Bernard ,  WAGNON, Jean

IPC分类号： C07D401/04 ,  C07D403/04 ,  A61K31/472 ,  A61K31/404 ,  A61P25/00 ,  A61P9/00 ,  A61P3/00

CPC分类号： C07D401/04 ,  C07D209/42 ,  C07D403/04

摘要： The invention concerns compounds of formula (I) and their solvates and/or hydrates, having affinity and selectivity for V1b or for both V1b and V1a arginine-vasopressin receptors. The invention also concerns a method for preparing them, intermediate compounds of formula (II) useful for preparing them, pharmaceutical compositions containing them, and their use for preparing medicines.

公开(公告)号：EP1259505A2

公开(公告)日：2002-11-27

申请号：EP01907866.6

申请日：2001-02-22

申请人： SANOFI-SYNTHELABO

发明人： SERRADEIL-LE GAL, Claudine ,  TONNERRE, Bernard ,  WAGNON, Jean

IPC分类号： C07D401/04 ,  C07D403/04 ,  A61K31/472 ,  A61K31/404 ,  A61P25/00 ,  A61P9/00 ,  A61P3/00

CPC分类号： C07D401/04 ,  C07D209/42 ,  C07D403/04

摘要： The invention concerns compounds of formula (I) and their solvates and/or hydrates, having affinity and selectivity for V1b or for both V1b and V1a arginine-vasopressin receptors. The invention also concerns a method for preparing them, intermediate compounds of formula (II) useful for preparing them, pharmaceutical compositions containing them, and their use for preparing medicines.

公开(公告)号：EP1254134A2

公开(公告)日：2002-11-06

申请号：EP01907687.6

申请日：2001-01-24

申请人： SANOFI-SYNTHELABO

发明人： SCHOENTJES, Bruno ,  SERRADEIL-LE GAL, Claudine ,  WAGNON, Jean

IPC分类号： C07D413/04 ,  A61K31/404 ,  A61P43/00

CPC分类号： C07D413/04

摘要： The invention concerns compounds of formula (I), and their solvates and/or hydrates, having affinity and selectivity for V1b receptors or for both V1b and V1a arginine-vasopressin receptors. The invention also concerns their method of preparation, intermediate compounds of formula (II) used for preparing them, pharmaceutical compositions containing them and their use for preparing medicines.

摘要翻译： 本发明涉及对V1b受体或V1b和V1a精氨酸加压素受体具有亲和力和选择性的式（I）化合物及其溶剂化物和/或水合物。 本发明还涉及它们的制备方法，用于制备它们的式（II）的中间体化合物，含有它们的药物组合物以及它们用于制备药物的用途。

公开(公告)号：EP0687251B1

公开(公告)日：2002-02-27

申请号：EP95905164.0

申请日：1994-12-23

申请人： SANOFI-SYNTHELABO

发明人： WAGNON, Jean ,  TONNERRE, Bernard ,  DI MALTA, Alain ,  ROUX, Richard ,  AMIEL, Marie-Sophie ,  SERRADEIL-LEGAL, Claudine

IPC分类号： C07D209/40 ,  A61K31/40 ,  C07D209/34 ,  C07D405/12

CPC分类号： C07D401/04 ,  C07D209/34 ,  C07D209/38 ,  C07D209/40 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D409/12 ,  Y02P20/55

公开(公告)号：EP1255751B1

公开(公告)日：2004-06-16

申请号：EP01907685.0

申请日：2001-01-24

申请人： SANOFI-SYNTHELABO

发明人： ROUX, Richard ,  SERRADEIL-LE GAL, Claudine ,  TONNERRE, Bernard ,  WAGNON, Jean

IPC分类号： C07D403/04 ,  A61K31/404 ,  A61P43/00 ,  C07D405/14

CPC分类号： C07D403/04 ,  A61K31/405 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541

摘要： The invention concerns compounds of formula (I) and their possible salts with mineral or organic acids, their solvates and/or hydrates, having affinity and selectivity for V1b receptor or for both V1b and V1a arginine-vasopressin receptors. The invention also concerns their preparation method, intermediate compounds of formula (II) used in their preparation, pharmaceutical compositions containing them for use in preparing medicines.

摘要翻译： 本发明涉及式（I）化合物及其与无机或有机酸，其溶剂合物和/或水合物可能的盐，其对V1b受体或对V1b和V1a精氨酸加压素受体具有亲和力和选择性。 本发明还涉及它们的制备方法，在其制备中使用的式（II）的中间体化合物，含有它们的药物组合物用于制备药物。

公开(公告)号：EP1254134B1

公开(公告)日：2003-07-23

申请号：EP01907687.6

申请日：2001-01-24

申请人： SANOFI-SYNTHELABO

发明人： SCHOENTJES, Bruno ,  SERRADEIL-LE GAL, Claudine ,  WAGNON, Jean

IPC分类号： C07D413/04 ,  A61K31/404 ,  A61P43/00

CPC分类号： C07D413/04

摘要： The invention concerns compounds of formula (I), and their solvates and/or hydrates, having affinity and selectivity for V1b receptors or for both V1b and V1a arginine-vasopressin receptors. The invention also concerns their method of preparation, intermediate compounds of formula (II) used for preparing them, pharmaceutical compositions containing them and their use for preparing medicines.

公开(公告)号：EP1296976A1

公开(公告)日：2003-04-02

申请号：EP01947534.2

申请日：2001-06-19

申请人： SANOFI-SYNTHELABO

发明人： ROUX, Richard ,  SERRADEIL-LE GAL, Claudine ,  WAGNON, Jean

IPC分类号： C07D403/04 ,  A61K31/404 ,  A61P5/00 ,  C07D401/04 ,  C07D405/14

CPC分类号： C07D401/04 ,  C07D403/04 ,  C07D405/14

摘要： The invention concerns compounds of formula (I) and their solvates and/or hydrates, exhibiting affinity and selectivity for V1b arginine-vasopressin receptors or for both V1b and V1a arginine-vasopressin receptors. The invention also concerns a method for preparing said compounds, intermediate compounds of formula (II) used in their preparation, pharmaceutical compositions containing them, and their use for preparing medicines.