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公开(公告)号：EP0736056B1
公开(公告)日：2002-05-08
申请号：EP95905095.6
申请日：1994-12-21
发明人： KRAUSE, Werner , MAIER, Franz-Karl , BAUER, Michael , SCHUHMANN-GIAMPIERI, Gabriele , PRESS, Wolf-Rüdiger
CPC分类号： A61K49/0442 , C08G69/04 , C08G73/0206 , C08G73/06 , C08G83/00
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2.发明公开NEUARTIG SUBSTITUIERTE DTPA-DERIVATE, DEREN METALLKOMPLEXE, DIESE KOMPLEXE ENTHALTENDE PHARMAZEUTISCHE MITTEL UND DEREN VERWENDUNG IN DER DIAGNOSTIK UND THERAPIE 失效创新取代DTPA衍生物，它们的金属络合物，这种复杂的制药含有它们的它们在诊断和治疗
公开(公告)号：EP0794938A1
公开(公告)日：1997-09-17
申请号：EP95940988.0
申请日：1995-11-20
发明人： MAIER, Franz-Karl , BAUER, Michael , KRAUSE, Werner , SPECK, Ulrich , SCHUHMANN-GIAMPIERI, Gabriele , MÜHLER, Andreas , BALZER, Thomas , PRESS, Wolf-Rüdiger
CPC分类号： A61K49/04 , A61K49/0002 , A61K49/0004 , A61K49/103 , Y10S514/836 , Y10T436/24
摘要： The invention concerns novel diethylenetriamine pentaacetic acid (DTPA) derivatives, their complexes and complex salts, containing an element of the atomic numbers 20 - 32, 39 - 51 or 57 - 83. The invention further concerns pharmaceutical compositions containing these compounds, their preparation and their use as contrast media and antidotes.
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3.发明公开NEUARTIGE, MEHRFACH SUBSTITUIERTE DTPA-DERIVATE UND DEREN METALLKOMPLEXE, DIESE KOMPLEXE ENTHALTENDE PHARMAZEUTISCHE MITTEL, DEREN VERWENDUNG IN DER DIAGNOSTIK UND THERAPIE, SOWIE VERFAHREN ZUR HERSTELLUNG DER KOMPLEXBILDNER UND KOMPLEXE UND VERFAHREN ZUR HERSTELLUNG PHARMAZEUTISCHER MITTEL 失效小说，多取代DTPA衍生物及其金属络合物，这种复杂的制药包含In的诊断和治疗，和方法使用用于生产复合状况及其复合及其制造方法药剂
公开(公告)号：EP0794939A1
公开(公告)日：1997-09-17
申请号：EP95941616.0
申请日：1995-11-20
发明人： MAIER, Franz-Karl , BAUER, Michael , KRAUSE, Werner , SPECK, Ulrich , SCHUHMANN-GIAMPIERI, Gabriele , MÜHLER, Andreas , BALZER, Thomas , PRESS, Wolf-Rüdiger
CPC分类号： A61K49/04 , A61K49/0002 , A61K49/0004 , A61K49/103 , Y10S514/836 , Y10T436/24
摘要： The invention concerns novel multiple-substituent diethylenetriamine pentaacetic acid derivatives, their complexes and complex salts, containing an element with the atomic numbers 20 - 32, 39 - 51 or 57 - 83, pharmaceutical compositions containing these compounds, methods of preparing the compounds, the use of the compositions as contrast media and antidotes, and methods of preparing the pharmaceutical compositions.
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4.发明公开
公开(公告)号：EP0775104A1
公开(公告)日：1997-05-28
申请号：EP95929815.0
申请日：1995-08-08
发明人： KRAUSE, Werner , MAIER, Franz-Karl , BAUER, Michael , PRESS, Wolf-Rüdiger , SCHUHMANN-GIAMPIERI, Gabriele , PLATZEK, Johannes , SCHMITT-WILLICH, Heribert
CPC分类号： C07C237/08 , A61K49/06 , A61K51/048 , C07C229/16 , C07C229/36 , C07C229/76 , C07C237/06
摘要： New dimer DTPA derivatives have the general formula (I) that consists of the increments (A) and (B) which are interconnected by one of the pairs of substituents R?1 and R1', R2 and R2', R15 and R15', R1 and R2', R1' and R2, R1' and R15, R1 and R15', R2 and R15', R2' and R15¿. The interconnecting substituent pairs stand for heterocycle, a phenylene residue, a C¿0?-C30-alkylene or C7-C30-aralkylene chain, which may be optionally substituted by 1-4 hydroxy, C1-C6-alkoxy, carboxy or mercapto groups and/or interrupted by 1 to 6 oxygen, nitrogen or sulphur atoms or sulfinyl and/or sulfonyl groups; Y stands for a hydrogen atom and/or a metal ion equivalent of an element having atomic numbers 21-32, 37-39, 42-51 and 57-83; and X and X' stand for a group -OY or -CONR?5R6¿. Also disclosed is the use of said metal complexes in NMR and/or röntgen diagnosis, in radiodiagnosis and radiotherapy, as well as a process for preparing the same.
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5.发明授权
公开(公告)号：EP0775104B1
公开(公告)日：1999-05-06
申请号：EP95929815.9
申请日：1995-08-08
发明人： KRAUSE, Werner , MAIER, Franz-Karl , BAUER, Michael , PRESS, Wolf-Rüdiger , SCHUHMANN-GIAMPIERI, Gabriele , PLATZEK, Johannes , SCHMITT-WILLICH, Heribert
IPC分类号： C07C229/26 , C07C229/36 , C07C237/08 , C07C229/22 , C07C237/06 , C07C229/16 , A61K49/00 , A61K49/04 , A61K51/04
CPC分类号： C07C237/08 , A61K49/06 , A61K51/048 , C07C229/16 , C07C229/36 , C07C229/76 , C07C237/06
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6.发明公开
公开(公告)号：EP0794799A2
公开(公告)日：1997-09-17
申请号：EP95936963.0
申请日：1995-11-20
发明人： MAIER, Franz-Karl , BAUER, Michael , KRAUSE, Werner , SPECK, Ulrich , SCHUHMANN-GIAMPIERI, Gabriele , MÜHLER, Andreas , BALZER, Thomas , PRESS, Wolf-Rüdiger
CPC分类号： A61K49/04 , A61K49/0002 , A61K49/0004 , A61K49/103 , Y10S514/836 , Y10T436/24
摘要： Metal complexes consisting of a metal of atomic number 39-42, 44-51 or 56-83, and a complexing agent are used to produce X-ray contrast media for use in enhanced-contrast computed tomography of the liver and the bile ducts.
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7.发明授权NEUARTIG SUBSTITUIERTE DTPA-DERIVATE, DEREN METALLKOMPLEXE, DIESE KOMPLEXE ENTHALTENDE PHARMAZEUTISCHE MITTEL, DEREN VERWENDUNG IN DER DIAGNOSTIK UND THERAPIE, SOWIE VERFAHREN ZUR HERSTELLUNG DER KOMPLEXE UND MITTEL 失效创新取代DTPA衍生物，它们的金属络合物，这种复杂的制药含在诊断和治疗中的应用，及其制造方法的复杂性和MEANS
公开(公告)号：EP0810989B1
公开(公告)日：1999-08-04
申请号：EP96902992.5
申请日：1996-02-21
发明人： KRAUSE, Werner , MAIER, Franz-Karl , BAUER, Michael , SCHUHMANN-GIAMPIERI, Gabriele , PRESS, Wolf-Rüdiger , MUSCHICK, Peter
IPC分类号： C07C229/76 , A61K49/00 , A61K31/195 , C07C229/16 , C07C229/22 , C07C233/83 , C07C237/06
CPC分类号： A61K49/06 , C07C229/16 , C07C229/36 , C07C233/63 , C07C233/83 , C07C237/06
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8.发明公开NEUARTIG SUBSTITUIERTE DTPA-DERIVATE, DEREN METALLKOMPLEXE, DIESE KOMPLEXE ENTHALTENDE PHARMAZEUTISCHE MITTEL, DEREN VERWENDUNG IN DER DIAGNOSTIK UND THERAPIE, SOWIE VERFAHREN ZUR HERSTELLUNG DER KOMPLEXE UND MITTEL 失效创新取代DTPA衍生物，它们的金属络合物，这种复杂的制药含在诊断和治疗中的应用，及其制造方法的复杂性和MEANS
公开(公告)号：EP0810989A1
公开(公告)日：1997-12-10
申请号：EP96902992.0
申请日：1996-02-21
发明人： KRAUSE, Werner , MAIER, Franz-Karl , BAUER, Michael , SCHUHMANN-GIAMPIERI, Gabriele , PRESS, Wolf-Rüdiger , MUSCHICK, Peter
CPC分类号： A61K49/06 , C07C229/16 , C07C229/36 , C07C233/63 , C07C233/83 , C07C237/06
摘要： The invention pertains to diethylenetriaminepentaacetic acid derivatives, their complexes and complex salts, containing an element of atomic number 20-32, 39-51 or 57-83, pharmaceuticals containing these compounds, their use as contrast medium and antidote, and methods for preparing them.
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公开(公告)号：EP0736056A1
公开(公告)日：1996-10-09
申请号：EP95905095.0
申请日：1994-12-21
发明人： KRAUSE, Werner , MAIER, Franz-Karl , BAUER, Michael , SCHUHMANN-GIAMPIERI, Gabriele , PRESS, Wolf-Rüdiger
CPC分类号： A61K49/0442 , C08G69/04 , C08G73/0206 , C08G73/06 , C08G83/00
摘要： Iodine-containing dendrimer polymers have the general formula (I) A-(X)b, in which A stands for a hydrogenated core of index b, b being 1 to 8, X stands for a residue composed of (a) repetitive units S and maximum 2n image-generating residues Z, n determines the number of generations and is 1 to 10, and S and Z have different meanings. These polymers are precious X-ray diagnostic agents.
摘要翻译： 含碘树枝聚体聚合物具有通式（I）A-（X）b，其中A代表指数b的氢化核心，b为1至8，X代表由（a）重复单元S 并且最大2n个图像产生残基Z，n确定世代的数目为1至10，并且S和Z具有不同的含义。 这些聚合物是贵重的X射线诊断剂。
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