公开(公告)号：EP2185272B1

公开(公告)日：2018-05-02

申请号：EP08798327.6

申请日：2008-08-21

Applicant: Liebel-Flarsheim Company LLC

Inventor： BAILEY, Allan, R. ,  WHITE, David, H. ,  KASPAR, Derick, L. ,  VANDAS, Robert, E. ,  GENTILCORE, Michael, J. ,  NGUYEN, Hung, V. ,  FUKUNAGA, Anna, K.

IPC: B01D61/02 ,  A61K49/04 ,  B01D15/32

CPC classification number: B01D61/027 ,  A61K49/0433 ,  A61K49/103 ,  A61K49/106 ,  B01D15/325 ,  B01D2315/16

Abstract: A process for separating soluble silica species such as monomeric silicic acid (or monosilicic acid) and low molecular weight soluble polymeric silica from impure water soluble compounds by membrane nanofiltration is provided. A process for separating soluble silica species and colloidal silica from impure water soluble compounds by reverse phase liquid chromatography is also provided.

公开(公告)号：EP2720999B1

公开(公告)日：2017-08-23

申请号：EP12728812.4

申请日：2012-06-06

Applicant: Koninklijke Philips N.V.

Inventor： GRUELL, Holger ,  LANGEREIS, Sander ,  LUB, Johan

IPC: C07C69/28 ,  C07C69/708 ,  C07C69/33 ,  A61K9/127 ,  A61K47/14 ,  A61K49/08 ,  A61K49/10 ,  A61K49/18

CPC classification number: A61K47/14 ,  A61K9/1272 ,  A61K9/1273 ,  A61K41/0028 ,  A61K49/085 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  A61K49/1812 ,  C07C69/28 ,  C07C69/33 ,  C07C69/708

公开(公告)号：EP3077009A1

公开(公告)日：2016-10-12

申请号：EP14867417.9

申请日：2014-12-03

Applicant: The General Hospital Corporation

Inventor： CARAVAN, Peter

IPC: A61K49/10 ,  A61K51/00 ,  A61K47/48 ,  A61B5/00

CPC classification number: C07F5/003 ,  A61K49/103 ,  A61K49/106 ,  A61K51/0482 ,  C07F1/08 ,  G01N33/57488 ,  G01N33/6893 ,  G01N2333/765

Abstract: This disclosure relates to compounds of formula (I) shown below: [formula (I)], or a pharmaceutically acceptable salt thereof. These compounds can be used as imaging probes, e.g., for diagnosis of fibrosis or fibrogenesis.

Abstract translation: 本公开涉及下述式（I）的化合物：[式（I）]或其药学上可接受的盐。 这些化合物可用作成像探针，例如用于诊断纤维化或纤维发生。

公开(公告)号：EP2932983A4

公开(公告)日：2016-08-17

申请号：EP13863271

申请日：2013-12-09

Applicant: UNIV KUMAMOTO NAT UNIV CORP ,  UNIV OCCUPATIONAL AND ENVIRONMENTAL HEALTH JAPAN ,  SBI PHARMACEUTICALS CO LTD

Inventor： YONEDA TETSUYA ,  NISHIZAWA SHIGERU ,  YAMAMOTO JUNKOH ,  TANAKA TOHRU ,  ITOH HIDENORI

IPC: A61K49/18 ,  A61B5/055 ,  A61K49/00 ,  A61K49/10 ,  G01R33/28 ,  G01R33/56

CPC classification number: A61K49/103 ,  A61B5/055 ,  A61K49/10 ,  A61K49/1836 ,  C07C229/22 ,  G01R33/5601

Abstract: [Problem] To provide a nuclear magnetic resonance diagnostic agent that has a lower toxicity to organisms and reduced side effects and yet has a site specificity toward a specific cell, tissue, organ, etc. [Solution] When ALA or an ALA derivative is administered in vivo, a metabolite thereof is accumulated in a specific cell, tissue, organ, etc. Focusing on this phenomenon, a nuclear magnetic resonance analysis was performed on a site wherein the metabolite of ALA that had been administered in vivo would be possibly accumulated. As a result, it was surprisingly found that ALA and an ALA derivative are useful as a diagnostic agent whereby the aforesaid problem can be solved.

公开(公告)号：EP3015855A1

公开(公告)日：2016-05-04

申请号：EP14190482.1

申请日：2014-10-27

Applicant: Klinikum rechts der Isar der Technischen Universität München ,  Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH

Inventor： Westmeyer, Gil Gregor ,  Mishra, Anurag ,  Pariani, Giorgio

IPC: G01N24/08 ,  A61B5/055 ,  A61K49/06 ,  G01R33/28 ,  G01R33/465 ,  G01R33/56

CPC classification number: G01N24/08 ,  A61B5/055 ,  A61K49/103 ,  G01R33/281 ,  G01R33/465 ,  G01R33/5601

Abstract: The present invention relates to the use of compounds with at least one metal-sensitive chemical shift for determining metal concentrations and/or measuring metal concentration changes, wherein the compound is selected from the group of: pyro-EGTA, EGTA, EDTA, AATA, APTRA, BAPTA, HIDA, citrate, CarboxyGlutamate (CGlu), arylazo chromotopic acid, beta-diketone (crown-ether), mono-, di-, or tri-pyridyl aniline, mono-, di-, or tri-pyridyl amine, trimethylphenylammonium, or derivatives thereof. The present invention further relates to biosensors comprising at least one of the compounds. The present invention also relates to the use of the compounds for diagnosing and/or monitoring treatment of a disease causing changes in metal concentrations. The present invention is furthermore related to in vitro and in vivo methods for determining metal concentration and/or measuring metal concentration changes using the compounds or biosensors. The present invention also relates to methods of diagnosing and/or monitoring treatment of a disease causing changes in metal concentrations wherein the compounds or biosensors are applied. The present invention also relates to use of the compounds or biosensors in quality control of food or in the examination of plants and organisms or for monitoring of environmental resources. The present invention further relates to novel derivatives of pyro-EGTA, AATA, APTRA and BAPTA as well as their uses.

Abstract translation: 本发明涉及的化合物的用途与至少一种金属敏感性的化学位移为确定性采矿金属浓度和/或测量金属浓度的变化，worin所述化合物选自所组成的组：热释EGTA EGTA，EDTA，AATA， APTRA，BAPTA，HIDA，柠檬酸盐，羧基谷氨酸（cGlu），芳基偶氮chromotopic酸，β-二酮（冠醚），单 - ，二 - ，或三 - 吡啶基苯胺，单 - ，二 - ，或三 - 吡啶基胺， 三甲基苯基，或它们的衍生物。 本发明还涉及生物传感器包含所述化合物中的至少一种。 因此，本发明涉及使用所述化合物的用于诊断和/或监测治疗疾病引起金属浓度的变化。 本发明进一步更相关的体外和体内方法用于确定性采矿金属浓度和/或测量使用所述化合物或生物传感器的金属浓度的变化。 因此，本发明涉及诊断和/或监测治疗疾病引起金属浓度的变化的方法worin化合物或生物传感器被应用。 因此，本发明涉及在食品的质量控制或在植物和微生物的检查或用于环境资源的监测来使用这些化合物或生物传感器的。 本发明还涉及热释EGTA，AATA，APTRA和BAPTA以及它们的用途的新的衍生物。

公开(公告)号：EP2647392A2

公开(公告)日：2013-10-09

申请号：EP13174573.9

申请日：2008-06-20

Applicant: mivenion GmbH

Inventor： Wiebelitz, Ulrike

IPC: A61K49/04 ,  A61K51/04 ,  A61K49/06 ,  A61K49/10 ,  A61B6/00

CPC classification number: A61K51/0491 ,  A61B6/037 ,  A61B6/481 ,  A61K49/04 ,  A61K49/06 ,  A61K49/103 ,  A61K49/105

Abstract: The present invention relates to the use of a combination of several contrast agents having different imaging properties with respect to imaging representation.

Abstract translation: 本发明涉及在成像表现方面具有不同成像特性的几种造影剂的组合的用途。

公开(公告)号：EP2535326A1

公开(公告)日：2012-12-19

申请号：EP11170139.7

申请日：2011-06-16

Applicant: Koninklijke Philips Electronics N.V.

Inventor： Gruell, Holger ,  Langereis, Sander ,  Lub, Johan

IPC: C07C69/28 ,  C07C69/708 ,  A61K9/127 ,  A61K47/48

CPC classification number: A61K47/14 ,  A61K9/1272 ,  A61K9/1273 ,  A61K41/0028 ,  A61K49/085 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  A61K49/1812 ,  C07C69/28 ,  C07C69/33 ,  C07C69/708

Abstract: Disclosed are lipidomimetic compounds of formula I

wherein:
G represents a group satisfying formula II:

         HO-CH 2 -{CH(OH)-CH 2 -O} p -CH 2 -{C(=O)-O-CH 2 } q-      formula II

each n independently is an integer from 1-30;
p is an integer from 1-10;
q is 0 or 1.
These compounds can be added to the lipid bilayer of thermosensitive liposomes, for the purpose of aiding in the prevention of leakage of the liposomes' contents at 37°C, and retarding clearance from circulation.

Abstract translation: 公开了式I的脂质模拟化合物，其中：G表示满足式II的基团：€ƒ€ƒ€ƒ€ƒ€ƒHO-CH 2 - {CH（OH）-CH 2 -O} p -CH 2 - {C（= O）-O-CH 2} q-€ƒ€ƒ€ƒformulaII每个n独立为1-30的整数; p是1-10的整数; q是0或1.这些化合物可以加入到热敏脂质体的脂双层中，以帮助防止在37℃下脂质体含量的泄漏，并延缓循环的清除。

公开(公告)号：EP1572245B1

公开(公告)日：2012-10-10

申请号：EP03786449.3

申请日：2003-12-16

Applicant: GE HEALTHCARE AS

Inventor： RONGVED, Pal ,  KARLSSON, Jan, O.G., Amersham Health AS ,  SÆBØ, Karen,Briley

IPC: A61K49/00 ,  A61B5/055 ,  A61K49/06 ,  A61K49/10

CPC classification number: A61B5/055 ,  A61B5/416 ,  A61K49/103

公开(公告)号：EP1931673B1

公开(公告)日：2012-08-29

申请号：EP06807100.0

申请日：2006-10-09

Applicant: GUERBET

Inventor： PORT, Marc

IPC: C07D487/04 ,  C07D257/02 ,  C07C211/05 ,  A61K51/04

CPC classification number: A61K49/085 ,  A61K49/10 ,  A61K49/103 ,  A61K49/106 ,  A61K49/14 ,  A61K51/0402 ,  A61K51/0478 ,  A61K51/0482 ,  C07D257/02 ,  C07D471/08 ,  C07D487/04

公开(公告)号：EP1963256A4

公开(公告)日：2012-06-13

申请号：EP06843372

申请日：2006-12-20

Applicant: FUJIFILM CORP

Inventor： HIRAI ATSUSHI ,  TAKAHASHI KAZUNOBU ,  NISHIGAKI JUNJI ,  AIKAWA KAZUHIRO

IPC: C07C229/76 ,  A61K9/127 ,  A61K49/08 ,  C07D317/22 ,  C07D323/00 ,  C07F5/00

CPC classification number: A61K9/127 ,  A61K47/543 ,  A61K49/085 ,  A61K49/10 ,  A61K49/103 ,  C07C229/24 ,  C07C233/36 ,  C07C311/04 ,  C07C317/18 ,  C07C323/12 ,  C07D317/22 ,  C07D323/00