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1.发明公开SPIROCYCLIC AZETIDINONE DERIVATIVES FOR THE TREATMENT OF DISORDERS OF LIPID METABOLISM, PAIN, DIABETES AND OTHER DISORDERS 审中-公开螺CYCLICAL氮杂环丁酮衍生物脂质代谢疾病，疼痛，糖尿病等疾病的治疗
公开(公告)号：EP2066668A1
公开(公告)日：2009-06-10
申请号：EP07838128.2
申请日：2007-09-13
申请人： Schering Corporation
IPC分类号： C07D471/10 , A61K31/438 , A61P3/06 , A61P3/10
CPC分类号： C07D471/10
摘要： The present invention relates to Spirocyclic Azetidinone Compounds, compositions comprising a Spirocyclic Azetidinone Compound and methods for treating or preventing a disorder of lipid metabolism, pain, diabetes, a vascular condition, demyelination or nonalcoholic fatty liver disease, comprising administering to a patient an effective amount of a Spirocyclic Azetidinone Compound.
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2.发明公开AZETIDINE AND AZETIDINONE DERIVATIVES USEFUL IN TREATING PAIN AND DISORDERS OF LIPID METABOLISM 审中-公开氮杂环丁烷而且AZETIDON衍生物疼痛和脂类代谢疾病治疗
公开(公告)号：EP2061796A2
公开(公告)日：2009-05-27
申请号：EP07811767.8
申请日：2007-09-13
申请人： Schering Corporation
IPC分类号： C07D487/10 , A61K31/4747 , A61P25/02 , A61P3/06
CPC分类号： C07D487/10
摘要： Disclosed are compounds of the formula (I), wherein Z1 is -CH2- or –C(O)-, R4 and R5 are carbon chains (and optionally, together can form a C2 bridge), u and v are independently an integer of 0-3 such that there sum is from 3 to 5, and R2 is heteroaryl, and R1 and R3 are as defined herein. Also disclosed are methods of treating pain, and methods of inhibiting the absorption of cholesterol using a compound of formula (I).
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公开(公告)号：EP1931683B1
公开(公告)日：2011-07-13
申请号：EP06813481.6
申请日：2006-08-16
申请人： Schering Corporation
IPC分类号： C07D495/14 , A61K31/519 , A61P25/00
CPC分类号： C07D495/14 , C07D471/14 , C07D487/14
摘要： In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J3, X, Z, and R1-R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluRI ) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.
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4.发明公开5-H-BENZO[D]NAPHTH[2,1-B]AZEPINE DERIVATIVE AS SELECTIVE D1/D5 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF OBESITY AND CNS DISORDERS 审中-公开5-H苯并[d]萘并[2,1-b]氮杂用于治疗肥胖和CNS障碍衍生物作为选择性D1 / D5受体拮抗剂
公开(公告)号：EP1646623A2
公开(公告)日：2006-04-19
申请号：EP04809387.6
申请日：2004-05-20
申请人： SCHERING CORPORATION
发明人： BURNETT, Duane A. , GREENLEE, William J. , MCKITTRICK, Brian , SU, Jing , ZHU, Zhaoning , SASIKUMAR, Thavalakulamgara K. , MAZZOLA, Robert , QIANG, Li , YE, Yuanzan
IPC分类号： C07D401/12
CPC分类号： C07D223/14
摘要： The present invention provides compounds of formula (I), which, are novel antagonists for D1/D5 receptors as well as methods for preparing such compounds. In another embodiment, the invention provides pharmaceutical compositions comprising such D1/D5 receptor antagonists as well as methods of using them to treat CNS disorders, obesity, metabolic disorders, eating disorders such as hyperphagia, and diabetes.
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5.发明公开AZETIDINE AND AZETIDONE DERIVATIVES USEFUL IN TREATING PAIN AND DISORDERS OF LIPID METABOLISM 审中-公开氮杂环丁烷而且AZETIDONDERIVATE疼痛和脂类代谢疾病治疗
公开(公告)号：EP2066316A1
公开(公告)日：2009-06-10
申请号：EP07838156.3
申请日：2007-09-13
申请人： Schering Corporation
发明人： MCKITTRICK, Brian , SMITH, Elizabeth M. , BENNETT, Chad E. , BURNETT, Duane A. , KNUTSON, Chad E.
IPC分类号： A61K31/397 , C07D471/10 , C07D487/10 , A61K31/438 , A61P29/00
CPC分类号： C07D471/10 , C07D487/10
摘要： Disclosed are compounds of formula (I) wherein Z1 is -CH2- or -C(O)-, R4 and R5 are carbon chains (and optionally, together can form a C2 bridge), u and v are independently an integer of 0-3 such that there sum is from 3 to 5, and R2 is heteroaryl, and R1 and R3 are as defined herein. Also disclosed are methods of treating pain using a compound of formula (I).
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公开(公告)号：EP1931683A1
公开(公告)日：2008-06-18
申请号：EP06813481.6
申请日：2006-08-16
申请人： Schering Corporation
IPC分类号： C07D495/14 , A61K31/519 , A61P25/00
CPC分类号： C07D495/14 , C07D471/14 , C07D487/14
摘要： In its many embodiments, the present invention provides tricyclic compounds of formula I (wherein J1-J3, X, Z, and R1-R4 are as defined herein) useful as metabotropic glutamate receptor (mGluR) antagonists, particularly as selective metabotropic glutamate receptor 1 antagonists, pharmaceutical compositions containing the compounds, and methods of treatment using the compounds and compositions to treat diseases associated with metabotropic glutamate receptor (e.g., mGluRI ) such as, for example, pain, migraine, anxiety, urinary incontinence and neurodegenerative diseases such Alzheimer's disease.
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