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公开(公告)号：EP1545533A1
公开(公告)日：2005-06-29
申请号：EP03794594.6
申请日：2003-09-03
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , KNUTSON, Chad , MCKITTRICK, Brian , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhen Min , JAMES, Ray, Anthony , PARK, Haengsoon
IPC分类号： A61K31/50 , A61P35/00 , C07D487/04
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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2.发明授权PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS 有权并[1,5-A]嘧啶类作为抑制剂细胞周期蛋白依赖性激酶
公开(公告)号：EP1534712B1
公开(公告)日：2007-05-16
申请号：EP03796321.2
申请日：2003-09-03
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , ALVAREZ, Carmen, S. , CHAN, Tin-Yau , KNUTSON, Chad , MADISON, Vincent , FISCHMANN, Thierry, O. , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhen Min , JAMES, Ray, Anthony , PARK, Haengsoon
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61P35/00
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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公开(公告)号：EP1537116A1
公开(公告)日：2005-06-08
申请号：EP03794592.0
申请日：2003-09-03
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , MALLAMS, Alan , ALVAREZ, Carmen, S. , KEERTIKAR, Kartik, M. , RIVERA, Jocelyn , CHAN, Tin-Yau , MADISON, Vincent , FISCHMANN, Thierry, O. , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhen Min , JAMES, Ray, Anthony , PARK, Haengsoon , PARADKAR, Vidyadhar, M. , HOBBS, Douglas, Walsh
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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公开(公告)号：EP1534709A1
公开(公告)日：2005-06-01
申请号：EP03749317.8
申请日：2003-09-03
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhen Min , JAMES, Ray, Anthony , PARK, Haengsoon
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61P35/00
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译： 在其许多实施方案中，本发明提供了一类作为细胞周期蛋白依赖性激酶抑制剂的新型吡唑并[1,5-a]嘧啶化合物，制备此类化合物的方法，含有一种或多种此类化合物的药物组合物，制备药物制剂的方法 包含一种或多种这样的化合物以及使用这些化合物或药物组合物治疗，预防，抑制或改善与CDK相关的一种或多种疾病的方法。
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公开(公告)号：EP1534709B1
公开(公告)日：2007-06-13
申请号：EP03749317.8
申请日：2003-09-03
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhen Min , JAMES, Ray, Anthony , PARK, Haengsoon
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61P35/00
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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公开(公告)号：EP1891017A1
公开(公告)日：2008-02-27
申请号：EP05758425.2
申请日：2005-06-13
发明人： LETOURNEAU, Jeffrey, John , PARADKAR, Vidyadhar , OHLMEYER, Michael, H., J. , DILLARD, Lawrence, W. , BALDWIN, John, J. , RIVIELLO, Christopher, Mark , WONG, Angela , RONG, Yajing
IPC分类号： C07D235/30 , C07D403/12 , C07D215/38 , C07D405/12 , C07D401/12 , A61K31/4184 , A61P35/00
摘要： Nitrogen heterocycle biaryls having a carboxylate terminus are useful for treating endometriosis, osteoporosis, restenosis following angioplasty, rheumatoid arthritis, cancer, macular degeneration and obesity. Compounds of formula: (I) are disclosed. A representative example is : (II)
摘要翻译： 具有羧酸酯末端的氮杂环联芳基化合物可用于治疗子宫内膜异位症，骨质疏松症，血管成形术后的再狭窄，类风湿性关节炎，癌症，黄斑变性和肥胖症。 式（I）化合物被公开。 一个具有代表性的例子是：（二）
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公开(公告)号：EP1534710B1
公开(公告)日：2007-10-24
申请号：EP03749347.5
申请日：2003-09-03
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhen Min , JAMES, Ray, Anthony , PARK, Haengsoon
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/52 , A61K31/704 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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8.发明公开PYRAZOLO[1,5-A]PYRIMIDINE COMPOUNDS AS CYCLIN DEPENDENT KINASE INHIBITORS 有权并[1,5-A]嘧啶类作为抑制剂细胞周期蛋白依赖性激酶
公开(公告)号：EP1534712A2
公开(公告)日：2005-06-01
申请号：EP03796321.2
申请日：2003-09-03
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , ALVAREZ, Carmen, S. , CHAN, Tin-Yau , KNUTSON, Chad , MADISON, Vincent , FISCHMANN, Thierry, O. , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhen Min , JAMES, Ray, Anthony , PARK, Haengsoon
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61P35/00
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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公开(公告)号：EP1537116B1
公开(公告)日：2010-06-02
申请号：EP03794592.0
申请日：2003-09-03
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , MALLAMS, Alan , ALVAREZ, Carmen, S. , KEERTIKAR, Kartik, M. , RIVERA, Jocelyn , CHAN, Tin-Yau , MADISON, Vincent , FISCHMANN, Thierry, O. , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhen Min , JAMES, Ray, Anthony , PARK, Haengsoon , PARADKAR, Vidyadhar, M. , HOBBS, Douglas, Walsh
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07D487/04
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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公开(公告)号：EP1534710A1
公开(公告)日：2005-06-01
申请号：EP03749347.5
申请日：2003-09-03
发明人： GUZI, Timothy, J. , PARUCH, Kamil , DWYER, Michael, P. , DOLL, Ronald, J. , GIRIJAVALLABHAN, Viyyoor, Moopil , DILLARD, Lawrence, W. , TRAN, Vinh, D. , HE, Zhen Min , JAMES, Ray, Anthony , PARK, Haengsoon
IPC分类号： C07D487/04 , A61K31/519 , A61P25/00 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/52 , A61K31/704 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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