公开(公告)号：EP2884978A4

公开(公告)日：2016-01-13

申请号：EP13829428

申请日：2013-08-16

申请人： SCRIPPS RESEARCH INST

发明人： ROBERTS EDWARD ,  GUERRERO MIGUEL A ,  URBANO MARIANGELA ,  ROSEN HUGH

IPC分类号： A61K31/435 ,  A61K31/4545 ,  A61P25/04 ,  A61P25/28 ,  A61P37/02 ,  C07D211/58 ,  C07D401/04 ,  C07D405/14 ,  C07D413/14

CPC分类号： C07D405/14 ,  C07D211/58 ,  C07D401/04 ,  C07D413/14

摘要： The invention provides novel ligands of Kappa (κ) opioid receptors, such as can be used to modulate a Kappa opioid receptor. Methods of synthesis and methods of use are also provided. Compounds of the invention can be used therapeutically in the treatment of dissociative disorders or pain, or to provide neuroprotection, or to induce diuresis, or to modulate the immune system, or for treatment of one or more of an affective disorders comprising depression or stress/anxiety; an addictive disorder; alcoholism, epilepsy; a cognition deficiency; schizophrenia; Alzheimer's disease; or pain.

公开(公告)号：EP3209732A4

公开(公告)日：2018-04-18

申请号：EP15846300

申请日：2015-09-28

申请人： SCRIPPS RESEARCH INST

发明人： ROBERTS EDWARD ,  ROSEN HUGH ,  URBANO MARIANGELA ,  GUERRERO MIGUEL A

IPC分类号： C09B11/00

CPC分类号： C07D471/04 ,  C07C255/63 ,  C07D211/16 ,  C07D213/38 ,  C07D213/40 ,  C07D213/55 ,  C07D213/61 ,  C07D213/75 ,  C07D213/78 ,  C07D213/80 ,  C07D215/12 ,  C07D217/18 ,  C07D235/14 ,  C07D237/08 ,  C07D239/26 ,  C07D239/30 ,  C07D241/16 ,  C07D241/42 ,  C07D249/08 ,  C07D263/32 ,  C07D263/58 ,  C07D271/06 ,  C07D271/10 ,  C07D285/12 ,  C07D309/06 ,  C07D309/14 ,  C07D333/20 ,  C07D401/12 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  C07D413/04 ,  C07D413/06 ,  C07D413/12 ,  C07D413/14 ,  C09B55/002 ,  C09B55/005 ,  C09B55/007

摘要： The invention provides compounds effective as sphingosine-1-phosphate receptor modulators for treatment of cardiopulmonary diseases, such as hypertension (including malignant hypertension), angina, myocardial infarction, cardiac arrhythmias, congestive heart failure, coronary heart disease, atherosclerosis, angina pectoris, dysrhythmias, cardiomyothopy (including hypertropic cardiomyothopy), heart failure, cardiac arrest, bronchitis, asthma, chronic obstructive pulmonary disease, cystic fibrosis, croup, emphysema, pleurisy, pulmonary fibrosis, pneumonia, pulmonary embolus, pulmonary hypertension, mesothelioma, ventricular conduction abnormalities, complete heart block, adult respiratory distress syndrome, sepsis syndrome, idiopathic pulmonary fibrosis, scleroderma, systemic sclerosis, retroperitoneal fibrosis, prevention of keloid formation, or cirrhosis.

公开(公告)号：EP2291080A4

公开(公告)日：2013-09-11

申请号：EP09762826

申请日：2009-05-14

申请人： SCRIPPS RESEARCH INST

发明人： ROBERTS EDWARD ,  ROSEN HUGH ,  BROWN STEVEN ,  GUERRERO MIGUEL A ,  PENG XUEMEI ,  PODDUTOORI RAMULU

IPC分类号： C07D271/06 ,  A01N43/82 ,  A61K31/41 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.