公开(公告)号：EP2291080A4

公开(公告)日：2013-09-11

申请号：EP09762826

申请日：2009-05-14

申请人： SCRIPPS RESEARCH INST

发明人： ROBERTS EDWARD ,  ROSEN HUGH ,  BROWN STEVEN ,  GUERRERO MIGUEL A ,  PENG XUEMEI ,  PODDUTOORI RAMULU

IPC分类号： C07D271/06 ,  A01N43/82 ,  A61K31/41 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

CPC分类号： C07D271/06 ,  A61K31/4245 ,  C07D263/32 ,  C07D401/04 ,  C07D413/04 ,  C07D413/14 ,  C07D471/04

摘要： Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-1-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.