公开(公告)号：EP4361175A1

公开(公告)日：2024-05-01

申请号：EP22828434.5

申请日：2022-06-21

申请人： SEKISUI CHEMICAL CO., LTD. ,  Epsilon Molecular Engineering Inc.

发明人： KASHIWAGI Kenji ,  YANAGISAWA Teruhiko ,  YONEHARA Ryo ,  KUMACHI Shigefumi ,  NAKAO Kanako ,  TSUCHIYA Masayuki

IPC分类号： C07K16/28 ,  C07K16/46 ,  C12N15/13

CPC分类号： C07K16/46 ,  C07K16/00 ,  C07K16/28

摘要： A receptor tyrosine kinase agonist which is a single-domain antibody having a cell growth activity, and is at least one receptor tyrosine kinase agonist selected from the group consisting of a human fibroblast growth factor receptor 1 (FGFR1), a human fibroblast growth factor receptor 2 (FGFR2), a human fibroblast growth factor receptor 3 (FGFR3), and a human fibroblast growth factor receptor 4 (FGFR4).

公开(公告)号：EP4442704A1

公开(公告)日：2024-10-09

申请号：EP22901376.8

申请日：2022-11-30

申请人： Epsilon Molecular Engineering Inc. ,  Mitsui Knowledge Industry Co., Ltd.

发明人： MURAKAMI Taihei ,  KUMACHI Shigefumi ,  TSUCHIYA Masayuki ,  HIRAYAMA Hiroyuki

IPC分类号： C07K16/00 ,  C40B40/10

CPC分类号： C40B40/10 ,  C07K16/00

摘要： Provided are a peptide consisting of three complementarity determining regions and four framework regions, in which a framework 1 comprises an amino acid sequence represented by SEQ ID NO: 1, a framework 2 comprises an amino acid sequence represented by SEQ ID NO: 2, a framework 3 comprises an amino acid sequence represented by SEQ ID NO: 7, a framework 4 comprises an amino acid sequence represented by SEQ ID NO: 32, a complementarity determining region 1 is an amino acid sequence consisting of 10 amino acids, a complementarity determining region 2 is an amino acid sequence consisting of 16 or 17 amino acids, and a complementarity determining region 3 is an amino acid sequence consisting of 6, 12 or 15 amino acids; and a peptide library including the peptide.