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公开(公告)号：EP1460083A1
公开(公告)日：2004-09-22
申请号：EP04075084.6
申请日：1997-11-06
申请人： SEQUENOM, INC.
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/0262 , B01L3/0268 , B01L2200/025 , B01L2300/0838 , B01L2400/0439 , B01L2400/0487 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6858 , C12Q1/6872 , C12Q1/6883 , C12Q1/6886 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , C12Q2525/197 , C12Q2523/10 , C12Q2531/113 , C12Q2565/537 , C12Q2565/627 , C12Q2565/507 , C12Q2565/518 , C12Q2535/101
摘要： The invention provides a method for analyzing a material, comprising:
providing a vesicle suitable for carrying a fluid having said material therein,
disposing said vesicle adjacent a first location of a surface of a substrate,
controlling said vesicle to deliver a nanoliter volume of the fluid to provide a defined and controlled volume of said fluid at said first location of said surface of the substrate,
moving said vesicle to a second position adjacent a second location on said surface of the substrate to dispense a defined and controlled volume of said material along an array of locations on said substrate surface, and
performing mass spectrometry analysis for said material at each location of said array.摘要翻译： 本发明提供了一种用于分析材料的方法，包括：提供适于携带其中具有所述材料的流体的囊泡，将所述囊泡设置在基底表面的第一位置附近，控制所述囊泡以输送纳升体积的流体 以在衬底的所述表面的所述第一位置处提供限定和受控的体积的所述流体，将所述泡囊移动到邻近所述衬底的所述表面上的第二位置的第二位置，以沿着所述衬底的所述表面分配限定和受控体积的所述材料 在所述衬底表面上的位置阵列，并且在所述阵列的每个位置对所述材料进行质谱分析。
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公开(公告)号：EP1457496B1
公开(公告)日：2014-01-15
申请号：EP04075083.8
申请日：1997-11-06
申请人： SEQUENOM, INC.
发明人： Little, Daniel P. , Köster, Hubert
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/0262 , B01L3/0268 , B01L2200/025 , B01L2300/0838 , B01L2400/0439 , B01L2400/0487 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6858 , C12Q1/6872 , C12Q1/6883 , C12Q1/6886 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , C12Q2525/197 , C12Q2523/10 , C12Q2531/113 , C12Q2565/537 , C12Q2565/627 , C12Q2565/507 , C12Q2565/518 , C12Q2535/101
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3.发明公开
公开(公告)号：EP1296143A2
公开(公告)日：2003-03-26
申请号：EP02025544.4
申请日：1998-09-02
申请人： SEQUENOM, INC.
IPC分类号： G01N33/68
CPC分类号： G01N33/6848 , G01N33/6818 , G01N33/6842 , G01N33/6851 , H01J49/00
摘要： A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity.
摘要翻译： 提供了使用质谱法确定靶多肽的身份的方法。 根据待鉴定的靶多肽，可以使用所公开的方法，例如诊断遗传疾病或染色体异常，疾病或病症的倾向或病原生物的感染; 或用于确定身份或遗传。
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公开(公告)号：EP1164203B1
公开(公告)日：2007-10-10
申请号：EP01203019.3
申请日：1997-11-06
申请人： SEQUENOM, INC.
发明人： Köster, Hubert , Little, Daniel P. , Braun, Andreas , Jurinke, Christian , van den Boom, Dirk , Xiang, Guobing , Lough, David M. , Ruppert, Andreas , Hillenkamp, Franz
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C12Q1/6837 , C12Q1/6858 , C12Q1/6865 , C12Q1/6872 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , H01J49/00 , C12Q2565/507 , C12Q2565/537 , C12Q2523/10 , C12Q2565/627 , C12Q2525/197 , C12Q2531/113 , C12Q2565/518 , C12Q2535/101
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公开(公告)号：EP1164203A2
公开(公告)日：2001-12-19
申请号：EP01203019.3
申请日：1997-11-06
申请人： SEQUENOM, INC.
发明人： Köster, Hubert , Little, Daniel P. , Braun, Andreas , Jurinke, Christian , van den Boom, Dirk , Xiang, Guobing , Lough, David M. , Ruppert, Andreas , Hillenkamp, Franz
IPC分类号： C12Q1/68
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C12Q1/6837 , C12Q1/6858 , C12Q1/6865 , C12Q1/6872 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , H01J49/00 , C12Q2565/507 , C12Q2565/537 , C12Q2523/10 , C12Q2565/627 , C12Q2525/197 , C12Q2531/113 , C12Q2565/518 , C12Q2535/101
摘要： Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processed can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.
A method and apparatus for creating multiple branch wells from a parent well is disclosed. A multiple branching sub is provided for placement at a branching node of a well. Such sub includes a branching chamber and a plurality of branching outlet members. The outlet members during construction of the branching sub, have previously been distorted into oblong shapes so that all of the branching outlet members fit within an imaginary cylinder which is coaxial with and substantially the same radius as the branching chamber. After deployment of the branching sub via a parent casing in the well, a forming tool is lowered to the interior of the sub. The outlet members are extended outwardly by the forming tool and simultaneously formed into substantially round tubes. Next, each outlet member is plugged with cement, after which each branch well is drilled through a respective outlet member. If desired, each branch may be lined with casing and sealed to a branching outlet by means of a casing hanger. A manifold placed in the branching chamber controls the production of each branch well to the parent well.摘要翻译： 提供了用于检测生物样品中特定核酸序列的基于快速和高精度的基于质谱的方法。 根据检测的序列，可以使用经处理的例如诊断遗传疾病或染色体异常; 疾病或病症的倾向，病原体感染，或确定身份或遗传。 公开了一种用于从母井产生多个分支井的方法和装置。 提供多个分支子以用于放置在井的分支节点处。 这样的子部分包括分支室和多个分支出口构件。 分支支路构造期间的出口构件以前已经变形为长方形，使得所有分支出口构件装配在与分支室同轴并且与分支室基本相同的半径的假想圆柱体内。 在通过井中的母套管部署分支支路之后，成形工具下降到子的内部。 出口构件通过成形工具向外延伸并且同时形成为大致圆形的管。 接下来，每个出口构件用水泥塞住，然后通过相应的出口构件钻出每个分支井。 如果需要，每个分支可以衬有外壳并通过套管衣架密封到分支出口。 放置在分支室中的歧管控制每个分支井到母井的产生。
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公开(公告)号：EP1460083B1
公开(公告)日：2006-01-18
申请号：EP04075084.6
申请日：1997-11-06
申请人： SEQUENOM, INC.
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/0262 , B01L3/0268 , B01L2200/025 , B01L2300/0838 , B01L2400/0439 , B01L2400/0487 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6858 , C12Q1/6872 , C12Q1/6883 , C12Q1/6886 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , C12Q2525/197 , C12Q2523/10 , C12Q2531/113 , C12Q2565/537 , C12Q2565/627 , C12Q2565/507 , C12Q2565/518 , C12Q2535/101
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公开(公告)号：EP1296143A3
公开(公告)日：2004-02-04
申请号：EP02025544.4
申请日：1998-09-02
申请人： SEQUENOM, INC.
CPC分类号： G01N33/6848 , G01N33/6818 , G01N33/6842 , G01N33/6851 , H01J49/00
摘要： A process for determining the identity of a target polypeptide using mass spectroscopy is provided. Depending on the target polypeptide to be identified, a process as disclosed can be used, for example, to diagnose a genetic disease or chromosomal abnormality, a predisposition to a disease or condition, or infection by a pathogenic organism; or for determining identity or heredity.
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公开(公告)号：EP1164203A3
公开(公告)日：2002-03-13
申请号：EP01203019.3
申请日：1997-11-06
申请人： SEQUENOM, INC.
发明人： Köster, Hubert , Little, Daniel P. , Braun, Andreas , Jurinke, Christian , van den Boom, Dirk , Xiang, Guobing , Lough, David M. , Ruppert, Andreas , Hillenkamp, Franz
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C12Q1/6837 , C12Q1/6858 , C12Q1/6865 , C12Q1/6872 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , H01J49/00 , C12Q2565/507 , C12Q2565/537 , C12Q2523/10 , C12Q2565/627 , C12Q2525/197 , C12Q2531/113 , C12Q2565/518 , C12Q2535/101
摘要： Fast and highly accurate mass spectrometry-based processes for detecting a particular nucleic acid sequence in a biological sample are provided. Depending on the sequence to be detected, the processed can be used, for example, to diagnose a genetic disease or chromosomal abnormality; a predisposition to a disease or condition, infection by a pathogenic organism, or for determining identity or heredity.
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公开(公告)号：EP1296143B1
公开(公告)日：2009-06-03
申请号：EP02025544.4
申请日：1998-09-02
申请人： SEQUENOM, INC.
CPC分类号： G01N33/6848 , G01N33/6818 , G01N33/6842 , G01N33/6851 , H01J49/00
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10.发明公开
公开(公告)号：EP1457496A1
公开(公告)日：2004-09-15
申请号：EP04075083.8
申请日：1997-11-06
申请人： SEQUENOM, INC.
发明人： Little, Daniel P. , Köster, Hubert
CPC分类号： B01L3/0244 , B01J19/0046 , B01J2219/00315 , B01J2219/00317 , B01J2219/00387 , B01J2219/00468 , B01J2219/00497 , B01J2219/005 , B01J2219/00504 , B01J2219/00511 , B01J2219/0052 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/0072 , B01J2219/00722 , B01J2219/00725 , B01L3/0262 , B01L3/0268 , B01L2200/025 , B01L2300/0838 , B01L2400/0439 , B01L2400/0487 , C07B2200/11 , C07F9/2408 , C07F9/2429 , C07H21/00 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6858 , C12Q1/6872 , C12Q1/6883 , C12Q1/6886 , C40B40/06 , C40B40/10 , C40B60/14 , G01N35/1067 , G01N35/1074 , G01N2035/00237 , G01N2035/1037 , G01N2035/1069 , C12Q2525/197 , C12Q2523/10 , C12Q2531/113 , C12Q2565/537 , C12Q2565/627 , C12Q2565/507 , C12Q2565/518 , C12Q2535/101
摘要： The invention provides a dispensing apparatus for dispensing nanovolumes of fluid in chemical or biological procedures onto the surface of a substrate, comprising:
a housing having a plurality of sides and a bottom portion having formed therein a plurality of apertures, said sides and bottom portion of said housing defining an interior volume,
one or more fluid transmitting vesicles, mounted within said apertures, having a nanovolume sized fluid holding chamber for holding nanovolumes of fluid, said fluid holding chamber being disposed in fluid communication with said interior volume of said housing, and
dispensing means in communication with said interior volume of said housing for selectively dispensing nanovolumes of fluid from said nanovolume sized fluid transmitting vesicles when the fluid is loaded with said fluid holding chambers of said vesicles, whereby said dispensing means dispenses nanovolumes of the fluid onto the surface of the substrate when the apparatus is disposed over and in registration with the substrate.摘要翻译： 本发明提供了一种分配装置，用于将化学或生物过程中的纳摩尔流体分配到基底表面上，包括：壳体，其具有多个侧面和底部，其中形成有多个孔，所述侧面和底部 所述壳体限定内部容积，一个或多个流体传递囊泡，安装在所述孔内，具有用于保持流体的纳米体积的纳米体积大小的流体保持室，所述流体保持室设置成与所述壳体的所述内部体积流体连通， 分配装置与所述壳体的所述内部容积连通，用于当所述流体装载所述泡囊的所述流体保持室时选择性地分配来自所述纳米体积尺寸的流体传播囊泡的纳米体积的液体，由此所述分配装置将流体的纳米体积分配到所述表面上 当设备放置时基板的位置 r并与基板对准。
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