公开(公告)号：EP1787638A4

公开(公告)日：2008-12-03

申请号：EP05781769

申请日：2005-08-26

申请人： SHIJIAZHUANG PHARMA GROUP

发明人： LIU ZHENTAO ,  YANG LIYING ,  YANG HANYU ,  GAO YUQING ,  SHEN DONGMIN ,  GUO WENMIN ,  FENG XIAOLONG ,  ZHENG JIA

IPC分类号： A61K9/107 ,  A61K9/20 ,  A61K9/48 ,  A61K31/34 ,  A61P7/02

CPC分类号： A61K9/1075 ,  A61K9/0095 ,  A61K9/1617 ,  A61K9/2013 ,  A61K9/4858 ,  A61K31/34

摘要： The present invention relates to a novel drug delivery and release system, i.e. Self-emulsifying Drug Delievery System (SEDDS), of butylphthalide, to a preparation process thereof, and to a use thereof in a pharmaceutical formulation. The drug delivery system comprises as essential ingredients 1% to 65% of butylphthalide and 10% to 65% of a emulsifying agent, together with various excipients as required depending on the desired dosage forms. The present invention significantly increases the contact area between butylphthalide and the mucous membrane of the gastrointestinal tract, and therefore improves the absorptivity of the drug.

公开(公告)号：EP1709962A4

公开(公告)日：2010-02-10

申请号：EP05700438

申请日：2005-01-17

申请人： SHIJIAZHUANG PHARMA GROUP

发明人： LIU ZHENTAO ,  ZHANG HONGWU ,  NIU ZHANQI ,  SHEN DONGMIN ,  WANG RONGDUAN ,  FENG XIAOLONG

IPC分类号： A61K31/343 ,  A61P9/10

CPC分类号： A61K31/343

摘要： The present invention relates to the use of L-butylphthalide in the manufacturing of medicaments for the prevention and treatment of cerebral ischemia-induced disease. Cerebral ischemia of the animals or human induces cerebral infarction, neurological deficit, memory disorder, cerebral edema, cerebral apoplexy, metabolic disorder of energy, changes of cerebral blood flow, and the like. The in vivo experiments show that L-butylphthalide can effectively reduce the above-mentioned adverse symptoms induced by cerebral ischemia.

摘要翻译： 本发明涉及一种在制造药物中的脑缺血诱导的疾病的预防和治疗的使用L-丁基苯酞的。 动物或人类的脑缺血引起脑梗塞，神经功能缺损，记忆障碍，脑水肿，脑溢血，能量代谢紊乱，脑血流的变化，等等。 体内实验显示脑缺血做L-丁基苯酞可以有效地减少通过诱导上述不良症状。