公开(公告)号：EP1702612A4

公开(公告)日：2006-12-20

申请号：EP04802425

申请日：2004-12-03

申请人： SHIJIAZHUANG PHARMA GROUP ,  SHIJIAZHUANG PHARMA GROUP NBP

发明人： LI JIANQING ,  BAI MIN ,  GUO WENMIN ,  CHEN SURUI ,  LIU LIYUN ,  ZHOU GUIRONG

IPC分类号： A61K9/48 ,  A61K31/34

CPC分类号： A61K9/4825 ,  A61K9/4816 ,  A61K9/4875 ,  A61K31/34 ,  A61K31/365

摘要： The present invention discloses a novel dosage form of butylphthalide soft capsule and its preparation procedure. Butylphthalide soft capsule is composed of a coating material and a drug-containing oil. The drug-containing oil is basically composed of butylphthalide and diluent - vegetable oil, wherein the weight ratio of butylphthalide to oil ranges from 1:0~10. The coating material is composed of gelatin, plasticizer and water, wherein the weight ratio of gelatin to plasticizer to water is in the range of 1:0.2~0.4:0.8~0.3. The butylphthalide soft capsule described in this invention can mask the strong and specific flavour of butylphthalide, and overcome the difficulties associated with formulating oily active agents into other oral preparations. The disintegration time of the soft capsule complies with the requirement of Pharmacopoeia of P.R. China.

公开(公告)号：EP2123260A4

公开(公告)日：2010-03-17

申请号：EP07846229

申请日：2007-12-29

申请人： SHIJIAZHUANG PHARMA GROUP

发明人： LI CHUNLEI ,  WANG JINXU ,  WANG CAIXIA ,  LI YANHUI ,  SHEN DONGMIN ,  GUO WENMIN ,  ZHANG LI ,  ZHANG LAN

IPC分类号： A61K9/127 ,  A61K31/136 ,  A61K31/4375 ,  A61K31/475 ,  A61K47/24 ,  A61P35/00

CPC分类号： A61K9/1273 ,  A61K9/1271 ,  A61K31/136 ,  A61K31/704

摘要： A liposomal pharmaceutical formulation comprising multivalent ionic drug, a process for the preparation thereof, and the use thereof in the treatment of diseases, wherein the particle size of the liposome is about 30-80 nm, and the phospholipid bilayer contains a phospholipid with Tm> body temperature thereby the phase transition of the liposome is above body temperature.

公开(公告)号：EP1787638A4

公开(公告)日：2008-12-03

申请号：EP05781769

申请日：2005-08-26

申请人： SHIJIAZHUANG PHARMA GROUP

发明人： LIU ZHENTAO ,  YANG LIYING ,  YANG HANYU ,  GAO YUQING ,  SHEN DONGMIN ,  GUO WENMIN ,  FENG XIAOLONG ,  ZHENG JIA

IPC分类号： A61K9/107 ,  A61K9/20 ,  A61K9/48 ,  A61K31/34 ,  A61P7/02

CPC分类号： A61K9/1075 ,  A61K9/0095 ,  A61K9/1617 ,  A61K9/2013 ,  A61K9/4858 ,  A61K31/34

摘要： The present invention relates to a novel drug delivery and release system, i.e. Self-emulsifying Drug Delievery System (SEDDS), of butylphthalide, to a preparation process thereof, and to a use thereof in a pharmaceutical formulation. The drug delivery system comprises as essential ingredients 1% to 65% of butylphthalide and 10% to 65% of a emulsifying agent, together with various excipients as required depending on the desired dosage forms. The present invention significantly increases the contact area between butylphthalide and the mucous membrane of the gastrointestinal tract, and therefore improves the absorptivity of the drug.