公开(公告)号：EP0358484A3

公开(公告)日：1991-09-04

申请号：EP89309024.1

申请日：1989-09-06

申请人： SHIKOKU CHEMICALS CORPORATION

发明人： Sawa, Natsuo ,  Masuda, Takeshi ,  Miura, Shozo ,  Kano, Naoki ,  Kamagata, Kazuo ,  Ito, Masayuki

IPC分类号： C07D233/60 ,  C08G59/50 ,  C07D233/64

CPC分类号： C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： A process for producing a 1-benzylimidazole compound represented by the following formula (I)
wherein R₂ is lower alkyl or phenyl and R₄ is hydrogen or methyl
which comprises (a) heating a 1-unsubstituted imidazole compound of formula (II)
wherein R₂ and R₄ are as defined above, with (i) benzyl alcohol in the presence of a carboxylic acid, a carboxylic anhydride, a benzyl ester thereof or a lower alkyl ester thereof or (ii) with a benzyl ester of a carboxylic acid and (b) neutralizing the reaction product with an alkali.

公开(公告)号：EP0358484A2

公开(公告)日：1990-03-14

申请号：EP89309024.1

申请日：1989-09-06

申请人： SHIKOKU CHEMICALS CORPORATION

发明人： Sawa, Natsuo ,  Masuda, Takeshi ,  Miura, Shozo ,  Kano, Naoki ,  Kamagata, Kazuo ,  Ito, Masayuki

IPC分类号： C07D233/60 ,  C08G59/50 ,  C07D233/64

CPC分类号： C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08

摘要： A process for producing a 1-benzylimidazole compound represented by the following formula (I)
wherein R₂ is lower alkyl or phenyl and R₄ is hydrogen or methyl
which comprises (a) heating a 1-unsubstituted imidazole compound of formula (II)
wherein R₂ and R₄ are as defined above, with (i) benzyl alcohol in the presence of a carboxylic acid, a carboxylic anhydride, a benzyl ester thereof or a lower alkyl ester thereof or (ii) with a benzyl ester of a carboxylic acid and (b) neutralizing the reaction product with an alkali.

摘要翻译： 一种由下式（I）表示的1-苄基咪唑化合物的方法，其中R2是低级烷基或苯基，R4是氢或甲基，其包括（a）加热式（II）的1-未取代的咪唑化合物， 其中R 2和R 4如上定义，与（ⅰ）苄醇在羧酸，羧酸酐，其苄基酯或其低级烷基酯存在下，或（ⅱ）与 羧酸和（b）用碱中和反应产物。

公开(公告)号：EP0611758B1

公开(公告)日：1996-10-16

申请号：EP94301080.1

申请日：1994-02-15

申请人： SHIKOKU CHEMICALS CORPORATION

发明人： Murai, Takayuki ,  Saeki, Tokuichi ,  Satou, Suzuko ,  Miura, Shozo ,  Takashige, Tomoko ,  Ikeda, Yuichi ,  Kano, Naoki

IPC分类号： C07D233/68 ,  A61K31/415

CPC分类号： C07D233/68

公开(公告)号：EP0611758A1

公开(公告)日：1994-08-24

申请号：EP94301080.1

申请日：1994-02-15

申请人： SHIKOKU CHEMICALS CORPORATION

发明人： Murai, Takayuki ,  Saeki, Tokuichi ,  Satou, Suzuko ,  Miura, Shozo ,  Takashige, Tomoko ,  Ikeda, Yuichi ,  Kano, Naoki

IPC分类号： C07D233/68 ,  A61K31/415

CPC分类号： C07D233/68

摘要： A process for preparing, on an industrial scale, 4-halo-5(hydroxymethyl) imidazole compounds, shown below, that are useful as intermediates for medicines. A 4-halo-5(hydroxymethyl) imidazole compound is prepared by reacting a 4,5-bis(hydroxymethyl) imidazole compound with a halogenating agent such as an N-chlorosuccinimide, an N-bromosuccinimide or a chlorinated isocyanuric acid compound.

wherein R is a hydrogen atom, an alkyl group, an aryl group or an aralkyl group, and X is a halogen atom.

摘要翻译： 在工业规模上制备可用作药物中间体的下述的4-卤代-5-（羟甲基）咪唑化合物的方法。 通过使4,5-双（羟甲基）咪唑化合物与卤化剂如N-氯代琥珀酰亚胺，N-溴代琥珀酰亚胺或氯代异氰脲酸化合物反应来制备4-卤代-5-（羟甲基）咪唑化合物。 其中R是氢原子，烷基，芳基或芳烷基，X是卤素原子。

公开(公告)号：EP0358484B1

公开(公告)日：1994-07-13

申请号：EP89309024.1

申请日：1989-09-06

申请人： SHIKOKU CHEMICALS CORPORATION

发明人： Sawa, Natsuo ,  Masuda, Takeshi ,  Miura, Shozo ,  Kano, Naoki ,  Kamagata, Kazuo ,  Ito, Masayuki

IPC分类号： C07D233/60 ,  C08G59/50 ,  C07D233/64

CPC分类号： C07D233/64 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08