公开(公告)号：EP3150573A4

公开(公告)日：2018-02-21

申请号：EP15799305

申请日：2015-05-28

申请人： SHIONOGI & CO

发明人： TADANO GENTA ,  IKARASHI FUMIYA ,  OKAMOTO KAZUYA ,  MAKI TOSHIKATSU ,  HAGIHARA MOTOYUKI

IPC分类号： C07C45/49 ,  C07B61/00 ,  C07C49/794 ,  C07D239/94 ,  C07D403/12 ,  C07D413/12

CPC分类号： C07D403/12 ,  C07B61/00 ,  C07B2200/13 ,  C07C45/49 ,  C07C49/794 ,  C07C321/04 ,  C07D239/94 ,  C07D295/03 ,  C07D413/12

摘要： The present invention relates to a Sonogashira-Carbonylation reaction using two types of gas, as well as novel crystals which can control a heat of the said reaction and the process of producing the same. In addition, the present invention relates to a ligand (additive) to prevent the deactivation of a palladium catalyst.

公开(公告)号：EP2912035A4

公开(公告)日：2016-06-15

申请号：EP13848316

申请日：2013-10-23

申请人： SHIONOGI & CO

发明人： KUSAKABE KEN-ICHI ,  YOSHIDA SYUHEI ,  NAKAHARA KENJI ,  HASEGAWA TSUYOSHI ,  TADANO GENTA ,  FUCHINO KOUKI

IPC分类号： C07D413/12 ,  A61K31/5355 ,  A61K31/536 ,  A61K31/5365 ,  A61K31/553 ,  A61P25/28 ,  A61P43/00 ,  C07D498/04

CPC分类号： C07D413/12 ,  C07D413/04 ,  C07D413/14 ,  C07D498/04 ,  C07D498/10

摘要： The present invention provides a compound which has an effect of inhibiting amyloid &bgr; production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid &bgr; proteins. A compound of the formula (I): wherein X is —C(R3a)(R3b)—, —C(R3a)(R3b)—C(R3c)(R3d)— or —C(R3a)═C(R3c)—, R1 is substituted or unsubstituted alkyl or the like, R2a, R2b, R3a, R3b, R3c and R3d are each independently hydrogen, halogen or the like, R4 is hydrogen or halogen, Ring B is substituted or unsubstituted carbocycle or a substituted or unsubstituted heterocycle, or a pharmaceutically acceptable salt thereof.

公开(公告)号：EP2703401A4

公开(公告)日：2014-12-03

申请号：EP12777702

申请日：2012-04-25

申请人： SHIONOGI & CO

发明人： TADA YUKIO ,  KUSAKABE KEN-ICHI ,  TADANO GENTA

IPC分类号： C07D417/04 ,  A61K31/541 ,  A61P25/00 ,  A61P25/28 ,  A61P43/00 ,  C07D417/14 ,  C07D491/048 ,  C07D491/056

CPC分类号： C07D417/04 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/4858 ,  C07D417/14 ,  C07D491/048 ,  C07D491/056

公开(公告)号：EP2634188A4

公开(公告)日：2014-05-07

申请号：EP11836380

申请日：2011-10-27

申请人： SHIONOGI & CO

发明人： MASUI MORIYASU ,  TADANO GENTA

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P25/28 ,  A61P43/00

CPC分类号： C07D487/04 ,  A61K31/519