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1.发明公开METHOD FOR PRODUCING TRIPHENYLBUTENE DERIVATIVE 审中-公开VERFAHREN ZUR HERSTELLUNG VON TRIPHENYLBUTENDERIVAT
公开(公告)号：EP3181545A1
公开(公告)日：2017-06-21
申请号：EP15842755
申请日：2015-09-15
申请人： SHIONOGI & CO
发明人： OKAMOTO KAZUYA , UENO TATSUHIKO , TOYOTA TAKASHI , SATOU YUUSUKE
IPC分类号： C07C67/14 , C07B61/00 , C07C37/20 , C07C39/24 , C07C41/30 , C07C43/225 , C07C43/23 , C07C69/712 , C07C69/78
CPC分类号： C07C67/14 , C07B2200/13 , C07C37/20 , C07C37/68 , C07C41/26 , C07C41/30 , C07C67/29 , C07C67/31 , C07C69/734 , C07C69/736 , C07C69/78 , C07C39/373 , C07C43/23
摘要： We provide a novel and useful process for preparing triphenyl-butene derivative. A process for the preparation of a compound represented by Formula (IV): wherein R 1 is hydrogen or substituted or unsubstituted alkyl, characterized by reacting a compound represented by Formula (V): with a compound represented by Formula (VI): wherein R 1 has the same meaning as defined above, in the presence of 1) a polyvalent metal chloride, 2) a reducing agent and 3) an alkali metal salt and / or a substituted or unsubstituted phenol.
摘要翻译： 我们提供了一种新颖而有用的制备三苯基丁烯衍生物的方法。 （IV）表示的化合物的制备方法：其中R 1为氢或取代或未取代的烷基，其特征在于使式（V）所示的化合物：与式（VI）所示的化合物反应：其中R 1具有与上述定义相同的含义，在1）多价金属氯化物，2）还原剂和3）碱金属盐和/或取代或未取代的苯酚存在下进行。
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2.发明公开
公开(公告)号：EP2602260A4
公开(公告)日：2014-01-01
申请号：EP11814690
申请日：2011-08-04
申请人： SHIONOGI & CO
IPC分类号： C07D498/14 , A61K31/5365 , A61P31/18 , A61P43/00 , C07D211/94 , C07D213/80
CPC分类号： C07D498/14 , A61K31/5365 , C07B2200/13 , C07D213/80
摘要： A process for preparing a compound represented by formula (Y1) or (Y2) [wherein R x is an optionally substituted carbocyclyl lower alkyl, or the like] or a salt thereof, using a novel process for preparing a pyridone derivative represented by formula (X4) [wherein R 1d is hydrogen, halogen, or the like; R 2d is hydrogen, a lower alkyl optionally substituted with substituent E, or the like; R 4d is a lower alkyl optionally substituted with substituent E, or the like; and R 6d is a lower alkyl group optionally substituted with substituent group E, or the like].
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公开(公告)号：EP3181545A4
公开(公告)日：2018-08-01
申请号：EP15842755
申请日：2015-09-15
申请人： SHIONOGI & CO
发明人： OKAMOTO KAZUYA , UENO TATSUHIKO , TOYOTA TAKASHI , SATOU YUUSUKE
IPC分类号： C07C67/14 , C07C37/20 , C07C39/373 , C07C41/26 , C07C43/23 , C07C67/29 , C07C67/31 , C07C69/736 , C07C69/78
CPC分类号： C07C67/14 , C07B2200/13 , C07C37/20 , C07C37/68 , C07C41/26 , C07C41/30 , C07C67/29 , C07C67/31 , C07C69/734 , C07C69/736 , C07C69/78 , C07C39/373 , C07C43/23
摘要： We provide a novel and useful process for preparing triphenyl-butene derivative. A process for the preparation of a compound represented by Formula (IV): wherein R 1 is hydrogen or substituted or unsubstituted alkyl, characterized by reacting a compound represented by Formula (V): with a compound represented by Formula (VI): wherein R 1 has the same meaning as defined above, in the presence of 1) a polyvalent metal chloride, 2) a reducing agent and 3) an alkali metal salt and / or a substituted or unsubstituted phenol.
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公开(公告)号：EP3150573A4
公开(公告)日：2018-02-21
申请号：EP15799305
申请日：2015-05-28
申请人： SHIONOGI & CO
IPC分类号： C07C45/49 , C07B61/00 , C07C49/794 , C07D239/94 , C07D403/12 , C07D413/12
CPC分类号： C07D403/12 , C07B61/00 , C07B2200/13 , C07C45/49 , C07C49/794 , C07C321/04 , C07D239/94 , C07D295/03 , C07D413/12
摘要： The present invention relates to a Sonogashira-Carbonylation reaction using two types of gas, as well as novel crystals which can control a heat of the said reaction and the process of producing the same. In addition, the present invention relates to a ligand (additive) to prevent the deactivation of a palladium catalyst.
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公开(公告)号：EP2412709A4
公开(公告)日：2013-11-27
申请号：EP10756205
申请日：2010-03-26
申请人： SHIONOGI & CO
IPC分类号： C07D213/80 , C07D309/32 , C07D405/06
CPC分类号： C07D498/14 , C07D213/80 , C07D309/32 , C07D309/40 , C07D405/06 , C07D471/04 , C07D471/14
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公开(公告)号：EP2277881A4
公开(公告)日：2011-09-07
申请号：EP09732609
申请日：2009-04-16
申请人： SHIONOGI & CO
IPC分类号： C07D471/04 , A61K31/437 , A61K31/495 , A61P29/00 , C07D487/04
CPC分类号： C07D487/04
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