公开(公告)号：EP1544197A1

公开(公告)日：2005-06-22

申请号：EP05006670.3

申请日：1997-04-04

申请人： SHIONOGI & CO., LTD.

发明人： Nishitani, Yasuhiro ,  Ishikura, Koji

IPC分类号： C07D401/04 ,  C07D409/04

CPC分类号： C07D401/04 ,  C07D409/04 ,  C07D501/00

摘要： A cephem compound, wherein the cephem ring has a substituent at the 3-position, which substituent is shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the same or different from each other; R 1 is hydrogen, an optionally substituted lower alkyl or an optionally substituted lower alkenyl; A is an optionally substituted lower alkylene, an optionally substituted lower alkenylene or a single bond; B is an optionally substituted imino or a single bond; or A and B taken together may form a single bond; and D is a single bond or a group of the formula (a):

摘要翻译： 头孢烯化合物，其中头孢烯环在3位上具有取代基，该取代基由式II表示，其中Het是包含一个或多个选自N， O和S可以相同或不同; R 1是氢，任选取代的低级烷基或任选取代的低级烯基; A是任选取代的低级亚烷基，任选取代的低级亚烯基或单键; B是任选取代的亚氨基或单键; 或A和B组合在一起可形成单一债券; 和D是单键或式（a）的基团：

公开(公告)号：EP0409164A3

公开(公告)日：1991-04-17

申请号：EP90113679.6

申请日：1990-07-17

申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

发明人： Onoue, Hiroshi ,  Minami, Kyoji ,  Ishikura, Koji

IPC分类号： C07D501/36 ,  C07D505/00 ,  A61K31/545 ,  A61K31/535

CPC分类号： C07D505/00 ,  C07D501/00 ,  Y02P20/55

摘要： An antibacteriai 3-optionally protected-vic-dihydroxyaroyl-lower alkyl-pyridiniothiomethyl cephalosporin derivative represented by the following formula (I):
(wherein,
R 1 is an amino group or acylamino; R 2 is hydrogen or methoxy; R 3 is hydrogen or a mono- or divalent substituent; R 4 is optionally protected vic-dihydroxyaryl; R 5 is straight or branched lower alkylene; R 6 is hydrogen, a carboxy-protecting group or a negative charge when combined with Y; X is oxygen, sulfur, or sulfinyl; and Y is an anion or a negative charge when combined with R 6 ; and the dotted line shows the presence or absence of a bond), a disinfecting and treating method of bacterial infection using it, and synthetic methods thereof are provided.

公开(公告)号：EP1671966A1

公开(公告)日：2006-06-21

申请号：EP06005931.8

申请日：1997-04-04

申请人： SHIONOGI & CO., LTD.

发明人： Nishitani, Yasuhiro ,  Ishikura, Koji

IPC分类号： C07D401/04 ,  C07D409/04

CPC分类号： C07D401/04 ,  C07D409/04 ,  C07D501/00

摘要： A cephem compound, wherein the cephem ring has a substituent at the 3-position, which substituent is shown by the formula II, wherein Het is a mono- or polycyclic heterocyclic group comprising one or more hetero atoms selected from the group consisting of N, O and S which may be the same or different from each other; R 1 is hydrogen, an optionally substituted lower alkyl or an optionally substituted lower alkenyl; A is an optionally substituted lower alkylene, an optionally substituted lower alkenylene or a single bond; B is an optionally substituted imino or a single bond; or A and B taken together may form a single bond; and D is a single bond or a group of the formula (a):

摘要翻译： 头孢烯化合物，其中头孢烯环在3位上具有取代基，该取代基由式II表示，其中Het是包含一个或多个选自N， O和S可以相同或不同; R 1是氢，任选取代的低级烷基或任选取代的低级烯基; A是任选取代的低级亚烷基，任选取代的低级亚烯基或单键; B是任选取代的亚氨基或单键; 或A和B组合在一起可形成单一债券; 和D是单键或式（a）的基团：

公开(公告)号：EP0409164B1

公开(公告)日：1996-06-05

申请号：EP90113679.6

申请日：1990-07-17

申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

发明人： Onoue, Hiroshi ,  Minami, Kyoji ,  Ishikura, Koji

IPC分类号： C07D501/36 ,  C07D505/00 ,  A61K31/545 ,  A61K31/535

CPC分类号： C07D505/00 ,  C07D501/00 ,  Y02P20/55

公开(公告)号：EP0409164A2

公开(公告)日：1991-01-23

申请号：EP90113679.6

申请日：1990-07-17

申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

发明人： Onoue, Hiroshi ,  Minami, Kyoji ,  Ishikura, Koji

IPC分类号： C07D501/36 ,  C07D505/00 ,  A61K31/545 ,  A61K31/535

CPC分类号： C07D505/00 ,  C07D501/00 ,  Y02P20/55

摘要： An antibacteriai 3-optionally protected-vic-dihydroxyaroyl-lower alkyl-pyridiniothiomethyl cephalosporin derivative represented by the following formula (I):
(wherein,

R 1 is an amino group or acylamino; R 2 is hydrogen or methoxy; R 3 is hydrogen or a mono- or divalent substituent; R 4 is optionally protected vic-dihydroxyaryl; R 5 is straight or branched lower alkylene; R 6 is hydrogen, a carboxy-protecting group or a negative charge when combined with Y; X is oxygen, sulfur, or sulfinyl; and Y is an anion or a negative charge when combined with R 6 ; and the dotted line shows the presence or absence of a bond),
a disinfecting and treating method of bacterial infection using it, and synthetic methods thereof are provided.

摘要翻译： 由下式（I）表示的抗菌剂3-任选保护的 - 连接 - 二羟基芳酰基 - 低级烷基 - 吡啶硫基甲基头孢菌素衍生物：（其中，R1是氨基或酰氨基; R2是氢或甲氧基; R3是氢或单 - 或二价取代基; R 4是任选保护的vic-二羟基芳基; R 5是直链或支链低级亚烷基;当与Y结合时，R 6是氢，羧基保护基或负电荷; X是氧，硫或亚磺酰基;并且Y是 与R6结合时为阴离子或负电荷;虚线表示有无键），使用它的细菌感染的消毒和处理方法及其合成方法。