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1.发明授权Di-tert-butyl(hydroxy)phenylthio substituted hydroxamic acid derivatives 失效二（叔丁基（羟基）苯硫基取代物Hydroxamsäurederivate。
公开(公告)号：EP0405788B1
公开(公告)日：1994-03-09
申请号：EP90306401.2
申请日：1990-06-12
IPC分类号： C07C323/47 , C07C323/60 , C07C319/20 , A61K31/095
CPC分类号： C07C323/47 , C07C323/60
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2.发明公开Di-tert-butyl(hydroxy)phenylthio substituted hydroxamic acid derivatives 失效二（叔丁基（羟基）苯硫基取代物Hydroxamsäurederivate。
公开(公告)号：EP0405788A2
公开(公告)日：1991-01-02
申请号：EP90306401.2
申请日：1990-06-12
IPC分类号： C07C323/47 , C07C323/60 , C07C319/20 , A61K31/095
CPC分类号： C07C323/47 , C07C323/60
摘要： (Di-tert-butylhydroxyphneyl)thio substituted hydroxamic acid derivatives of the formula:
wherein X is straight or branched C₁ to C₁₆ alkylene which may be attached to Y through phenylene, provided that X is not n-butyl-methylene; Y is CO-N(OH) or N(OH)-CO; and R is hydrogen or straight or branched C₁ to C₉ alkyl, C₃ to C₉ cycloalkyl, aryl, or aralkyl, provided that R is not hydrogen when Y-R is N(OH)-CO-R; or a pharmacuetically acceptable salt thereof; useful in treating arteriosclerosis, ulcer, inflammation, allergy, or the like.摘要翻译： （二叔丁基羟基苯基）硫代取代的异羟肟酸衍生物，其结构式如下：其中X是直链或支链C 1 -C 16亚烷基，其可以通过亚苯连接到Y上，条件是X不是正丁基亚甲基; Y是CO-N（OH）或N（OH）-CO; R为氢或直链或支链C 1至C 9烷基，C 3至C 9环烷基，芳基或芳烷基，条件是当Y-R为N（OH）-CO-R时R不为氢; 或其药理学上可接受的盐; 可用于治疗动脉硬化，溃疡，炎症，变态反应等。
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公开(公告)号：EP0348203B1
公开(公告)日：1993-02-24
申请号：EP89306331.3
申请日：1989-06-23
发明人： Kita, Toru Chisan Mansion Ichijoji 603 , Narumiya, Shuh Sky Mansion 413, 561-4, Komanomachi , Narisada, Masayuki , Watanabe, Fumihiko , Matsumoto, Saichi , Doteuchi, Masami , Mizui, Takuji
IPC分类号： C07C323/22 , A61K31/10
CPC分类号： C07C323/52 , Y02P20/55 , Y10S514/824
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4.发明公开Phenolic thioethers, their production and use 失效PhenolischeThioäther，deren Herstellung und Verwendung。
公开(公告)号：EP0348203A1
公开(公告)日：1989-12-27
申请号：EP89306331.3
申请日：1989-06-23
发明人： Kita, Toru Chisan Mansion Ichijoji 603 , Narumiya, Shuh Sky Mansion 413, 561-4, Komanomachi , Narisada, Masayuki , Watanabe, Fumihiko , Matsumoto, Saichi , Doteuchi, Masami , Mizui, Takuji
IPC分类号： C07C323/22 , A61K31/10
CPC分类号： C07C323/52 , Y02P20/55 , Y10S514/824
摘要： Phenolic thioethers of the formula:
wherein R is a hydrogen atom or a protective group for carboxyl, X is a straight or branched C₄-C₁₅ alkylene group, a straight or branched C₁-C₁₅ alkylene group having a phenylene group or a straight or branched C₂-C₁₅ alkenylene group, and their salts, which inhibit the denaturation of low density lipoproteins (LDL) and the incorporation of LDL by macrophages and are useful as anti-arteriosclerosis agents.摘要翻译： 下式的酚醛硫醚：其中R是氢原子或羧基保护基，X是直链或支链C 4 -C 15亚烷基，具有亚苯基或直链的直链或支链C 1 -C 15亚烷基 或支链C 2 -C 15亚烯基及其盐，其抑制低密度脂蛋白（LDL）的变性和巨噬细胞的LDL掺入，并且可用作抗动脉硬化剂。
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5.发明公开
公开(公告)号：EP0405788A3
公开(公告)日：1991-04-17
申请号：EP90306401.2
申请日：1990-06-12
IPC分类号： C07C323/47 , C07C323/60 , C07C319/20 , A61K31/095
CPC分类号： C07C323/47 , C07C323/60
摘要： (Di-tert-butylhydroxyphneyl)thio substituted hydroxamic acid derivatives of the formula:
wherein X is straight or branched C₁ to C₁₆ alkylene which may be attached to Y through phenylene, provided that X is not n-butyl-methylene; Y is CO-N(OH) or N(OH)-CO; and R is hydrogen or straight or branched C₁ to C₉ alkyl, C₃ to C₉ cycloalkyl, aryl, or aralkyl, provided that R is not hydrogen when Y-R is N(OH)-CO-R; or a pharmacuetically acceptable salt thereof; useful in treating arteriosclerosis, ulcer, inflammation, allergy, or the like.
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