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    Thienopyridine derivatives
    2.
    发明公开
    Thienopyridine derivatives 失效
    噻吩衍生物

    公开(公告)号：EP0292051A3

    公开(公告)日：1990-03-21

    申请号：EP88200933.5

    申请日：1988-05-10

    申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

    发明人： Hirai, Kentaro 720, Uematsu-cho ,  Mizushima, Yukio ,  Doteuchi, Masami

    IPC分类号： C07D495/04 ,  A61K31/435

    CPC分类号： C07D495/04

    摘要： A compound of the formula:
    (wherein R¹ is hydrogen, C₁-C₅ alkyl, C₁-C₅ alkoxy, C₁-C₅ alkoxy­carbonyl, or trifluoromethyl; R² is hydrogen, C₁-C₅ alkoxycarbo­nyl, C₆-C₁₂ aryloxycarbonyl, C₁-C₅ alkanoyloxy-C₁-C₅ alkyl, C₁-C₅ alkoxycarbonyloxy-C₁-C₅ alkyl, C₁-C₅ acylamino-C₁-C₅ alkyl, 2-­hydroxy-1-C₂-C₅ alkenyl, phthalimido-C₁-C₅ alkyl, halogeno-C₁-C₅ alkoxycarbonyl-C₁-C₅ alkyl, hydroxy-C₁-C₅ alkyl, C₁-C₅ alkylthio-­C₁-C₅ alkyl, or C₁-C₅ alkylsulfinyl-C₁-C₅ alkyl;
    m is an integer of 0 or 1;
    R³ and R⁴ each is hydrogen, halogen, cyano, C₁-C₅ alkyl, amino, C₁-C₅ alkoxy, C₆-C₁₂ aryl-C₁-C₅ alkoxy, C₁-C₅ alkoxycarbonyl, fluoro-C₁-C₅ alkoxy, C₁-C₅ alkanoylamino, or carbamoyl) or its salt, being useful as antiulcer agents, is provided.

    Thienopyridine derivatives
    5.
    发明公开
    Thienopyridine derivatives 失效
    Thienopyridinderivate。

    公开(公告)号：EP0292051A2

    公开(公告)日：1988-11-23

    申请号：EP88200933.5

    申请日：1988-05-10

    申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

    发明人： Hirai, Kentaro 720, Uematsu-cho ,  Mizushima, Yukio ,  Doteuchi, Masami

    IPC分类号： C07D495/04 ,  A61K31/435

    CPC分类号： C07D495/04

    摘要： A compound of the formula:
    (wherein R¹ is hydrogen, C₁-C₅ alkyl, C₁-C₅ alkoxy, C₁-C₅ alkoxy­carbonyl, or trifluoromethyl; R² is hydrogen, C₁-C₅ alkoxycarbo­nyl, C₆-C₁₂ aryloxycarbonyl, C₁-C₅ alkanoyloxy-C₁-C₅ alkyl, C₁-C₅ alkoxycarbonyloxy-C₁-C₅ alkyl, C₁-C₅ acylamino-C₁-C₅ alkyl, 2-­hydroxy-1-C₂-C₅ alkenyl, phthalimido-C₁-C₅ alkyl, halogeno-C₁-C₅ alkoxycarbonyl-C₁-C₅ alkyl, hydroxy-C₁-C₅ alkyl, C₁-C₅ alkylthio-­C₁-C₅ alkyl, or C₁-C₅ alkylsulfinyl-C₁-C₅ alkyl;
    m is an integer of 0 or 1;
    R³ and R⁴ each is hydrogen, halogen, cyano, C₁-C₅ alkyl, amino, C₁-C₅ alkoxy, C₆-C₁₂ aryl-C₁-C₅ alkoxy, C₁-C₅ alkoxycarbonyl, fluoro-C₁-C₅ alkoxy, C₁-C₅ alkanoylamino, or carbamoyl) or its salt, being useful as antiulcer agents, is provided.

    摘要翻译： 下式的化合物：其中R 1是氢，C 1 -C 5烷基，C 1 -C 5烷氧基，C 1 -C 5烷氧羰基或三氟甲基; R 2是氢，C 1 -C 5烷氧羰基， C 1 -C 5烷酰氧基-C 1 -C 5烷基，C 1 -C 5烷氧基羰基氧基-C 1 -C 5烷基，C 1 -C 5酰基氨基-C 1 -C 5烷基，2-羟基-1- C 2 -C 5烯基，邻苯二甲酰亚氨基-C 1 -C 5烷基 ，卤代-C 1 -C 5烷氧基羰基-C 1 -C 5烷基，羟基-C 1 -C 5烷基，C 1 -C 5烷硫基-C 1 -C 5烷基或C 1 -C 5烷基亚磺酰基-C 1 -C 5烷基; CH 2是整数0 或1; R 3和R 4各自为氢，卤素，氰基，C 1 -C 5烷基，氨基，C 1 -C 5烷氧基，C 6 -C 12芳基-C 1 -C 5烷氧基，C 1 -C 5烷氧基羰基，氟-C1 -C 5烷氧基，C 1 -C 5烷酰基氨基或氨基甲酰基）或其盐，可用作抗溃疡剂。

    Di-tert-butyl(hydroxy)phenylthio substituted hydroxamic acid derivatives
    8.
    发明公开
    Di-tert-butyl(hydroxy)phenylthio substituted hydroxamic acid derivatives 失效
    二（叔丁基（羟基）苯硫基取代物Hydroxamsäurederivate。

    公开(公告)号：EP0405788A2

    公开(公告)日：1991-01-02

    申请号：EP90306401.2

    申请日：1990-06-12

    申请人： SHIONOGI SEIYAKU KABUSHIKI KAISHA trading under the name of SHIONOGI & CO. LTD.

    发明人： Matsumoto, Saichi ,  Mizui, Takuji, C/o Associate Prof Pak H. Chan ,  Doteuchi, Masami

    IPC分类号： C07C323/47 ,  C07C323/60 ,  C07C319/20 ,  A61K31/095

    CPC分类号： C07C323/47 ,  C07C323/60

    摘要： (Di-tert-butylhydroxyphneyl)thio substituted hydroxamic acid derivatives of the formula:
    wherein X is straight or branched C₁ to C₁₆ alkylene which may be attached to Y through phenylene, provided that X is not n-butyl-­methylene; Y is CO-N(OH) or N(OH)-CO; and R is hydrogen or straight or branched C₁ to C₉ alkyl, C₃ to C₉ cycloalkyl, aryl, or aralkyl, provided that R is not hydrogen when Y-R is N(OH)-CO-R; or a pharmacuetically acceptable salt thereof; useful in treating arteriosclerosis, ulcer, inflammation, allergy, or the like.

    摘要翻译： （二叔丁基羟基苯基）硫代取代的异羟肟酸衍生物，其结构式如下：其中X是直链或支链C 1 -C 16亚烷基，其可以通过亚苯连接到Y上，条件是X不是正丁基亚甲基; Y是CO-N（OH）或N（OH）-CO; R为氢或直链或支链C 1至C 9烷基，C 3至C 9环烷基，芳基或芳烷基，条件是当Y-R为N（OH）-CO-R时R不为氢; 或其药理学上可接受的盐; 可用于治疗动脉硬化，溃疡，炎症，变态反应等。