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公开(公告)号：EP0287110A3
公开(公告)日：1991-01-09
申请号：EP88106040.4
申请日：1988-04-15
发明人： Kondo, Eiji , Kawamura, Yoshimi , Tsuji, Naoki , Matsumoto, Koichi , Kobayashi, Masaaki , Kamigauchi, Toshiyuki , Hayashi, Yoshiyuki , Konishi, Takao
CPC分类号： C07K9/008
摘要： Glycopeptide antibiotics PA-45052 which are produced by Nocardia orientalis PA-45052, show potent activity against gram-positive bacteria, especially against methicillin-resistant bacteria and stimulate growth of animals.
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2.发明公开A phospholipase A2 inhibitor, method for producing it and pharmaceutical or veterinary formulations comprising said inhibitor 失效磷脂酶A2抑制剂，其制备方法和含有它的药物或兽药组合物的方法。
公开(公告)号：EP0395418A1
公开(公告)日：1990-10-31
申请号：EP90304552.4
申请日：1990-04-26
发明人： Yoshida, Tadasi , Arita, Hitoshi , Shoji, Jun'ichi , Inoue, Keizo , Matsutani, Shigeru , Kawamura, Yoshimi
IPC分类号： C07D311/82 , C12P17/06 , C12N1/14 , A61K31/35
CPC分类号： C12R1/645 , C07D311/82 , C12P17/06
摘要： A compound of the formula:
wherein the wave line means α-bond or β-bond, which compound is useful as a phospholipase A₂ inhibitor. Process for the production of the compound, pharmaceutical composition containing the compound, and a cell culture of a microorganism Thielavia terricola RF-143 producing the compound are also provided.摘要翻译： 式的化合物：
worin波浪线指α，β硼化物或硼化物，该化合物是作为磷脂酶A2抑制剂是有用的。 因此提供了用于生产所述化合物的，药物组合物，含有该化合物，和梭孢壳属微生物栖土RF-143制备化合物的细胞培养过程。 -
公开(公告)号：EP0459449B1
公开(公告)日：1994-12-21
申请号：EP91108805.2
申请日：1991-05-29
IPC分类号： C07D491/048 , C12P17/18 , A61K31/40
CPC分类号： C07D491/04 , C12P17/18
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公开(公告)号：EP0287110B1
公开(公告)日：1994-03-02
申请号：EP88106040.4
申请日：1988-04-15
发明人： Kondo, Eiji , Kawamura, Yoshimi , Tsuji, Naoki , Matsumoto, Koichi , Kobayashi, Masaaki , Kamigauchi, Toshiyuki , Hayashi, Yoshiyuki , Konishi, Takao
CPC分类号： C07K9/008
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公开(公告)号：EP0459449A1
公开(公告)日：1991-12-04
申请号：EP91108805.2
申请日：1991-05-29
IPC分类号： C07D491/048 , C12P17/18 , A61K31/40
CPC分类号： C07D491/04 , C12P17/18
摘要： The present invention relates to a novel aldose reductase inhibitor of the formula:
wherein X is methylene or carbonyl;
R is
R¹, R², R³, and R⁴ are each hydrogen or lower alkyl, to a method for producing the inhibitor by culturing Crucibulum sp. RF-3817 or its variants, and to an agent for inhibiting an aldose reductase comprising the inhibitor.摘要翻译： 本发明涉及下式的新型醛糖还原酶抑制剂：其中X是亚甲基或羰基; R为R 1，R 2，R 3和R 4各自为氢或低级烷基，通过培养Crucibulum sp制备抑制剂的方法。 RF-3817或其变体，以及用于抑制包含抑制剂的醛糖还原酶的药剂。
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6.发明授权A phospholipase A2 inhibitor, method for producing it and pharmaceutical or veterinary formulations comprising said inhibitor 失效磷脂酶A2抑制剂，其制备方法和含有它的药物或兽药组合物的方法。
公开(公告)号：EP0395418B1
公开(公告)日：1995-05-24
申请号：EP90304552.4
申请日：1990-04-26
发明人： Yoshida, Tadasi , Arita, Hitoshi , Shoji, Jun'ichi , Inoue, Keizo , Matsutani, Shigeru , Kawamura, Yoshimi
IPC分类号： C07D311/82 , C12P17/06 , C12N1/14 , A61K31/35
CPC分类号： C12R1/645 , C07D311/82 , C12P17/06
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7.发明授权Phospholipase A2 inhibitor, microorganisms producing said inhibitor and processes for its production 失效磷脂酶A2抑制剂，制备这些抑制剂和几种方法，用于其制备的微生物。
公开(公告)号：EP0405864B1
公开(公告)日：1995-04-12
申请号：EP90306872.4
申请日：1990-06-22
IPC分类号： C07D493/10 , C07D307/33 , C07C59/42 , C07C59/245 , C07C69/675 , C07C69/732 , C12P17/04 , C12N1/14 , A61K31/20 , A61K31/23 , A61K31/365
CPC分类号： C07D307/33 , C07C59/245 , C07C59/42 , C07C69/675 , C07C69/732 , C07D493/10 , C12P7/42 , C12P17/04 , C12R1/645
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8.发明公开Phospholipase A2 inhibitor, microorganisms producing said inhibitor and processes for its production 失效磷脂酶A2抑制剂，生产抑菌剂的微生物及其生产工艺
公开(公告)号：EP0405864A3
公开(公告)日：1992-01-08
申请号：EP90306872.4
申请日：1990-06-22
IPC分类号： C07D493/10 , C07D307/33 , C07C59/42 , C07C59/245 , C07C69/675 , C07C69/732 , C12P17/04 , C12N1/14 , A61K31/20 , A61K31/23 , A61K31/365
CPC分类号： C07D307/33 , C07C59/245 , C07C59/42 , C07C69/675 , C07C69/732 , C07D493/10 , C12P7/42 , C12P17/04 , C12R1/645
摘要： A compound of the formula (I);
wherein R 1 , R 2 , and R 3 are -COOR 4 , -COOR 5 , and -COOR 6 , respectively; R 4 , R 5 , and R 6 , are each hydrogen, lower alkyl, or alkali metal; W is hydroxyl; X, Y, and Z are each hydrogen or hydroxyl; the dotted line indicates the presence or absence of a single bond; and wherein W/R 3 , X/R 1 , and/or Z/R 3 may be combined together, to form a lactone, which compound is useful as a phospholipase A 2 inhibitor. A process for the production of the compound (I), a cell culture of a microorganism Circinotrichum falcatisporum RF-641 producing the same and pharmaceutical compositions containing the same are also provided.-
9.发明公开Phospholipase A2 inhibitor, microorganisms producing said inhibitor and processes for its production 失效磷脂酶A2抑制剂，制备这些抑制剂和几种方法，用于其制备的微生物。
公开(公告)号：EP0405864A2
公开(公告)日：1991-01-02
申请号：EP90306872.4
申请日：1990-06-22
IPC分类号： C07D493/10 , C07D307/33 , C07C59/42 , C07C59/245 , C07C69/675 , C07C69/732 , C12P17/04 , C12N1/14 , A61K31/20 , A61K31/23 , A61K31/365
CPC分类号： C07D307/33 , C07C59/245 , C07C59/42 , C07C69/675 , C07C69/732 , C07D493/10 , C12P7/42 , C12P17/04 , C12R1/645
摘要： A compound of the formula (I);
wherein R 1 , R 2 , and R 3 are -COOR 4 , -COOR 5 , and -COOR 6 , respectively; R 4 , R 5 , and R 6 , are each hydrogen, lower alkyl, or alkali metal; W is hydroxyl; X, Y, and Z are each hydrogen or hydroxyl; the dotted line indicates the presence or absence of a single bond; and wherein W/R 3 , X/R 1 , and/or Z/R 3 may be combined together, to form a lactone, which compound is useful as a phospholipase A 2 inhibitor. A process for the production of the compound (I), a cell culture of a microorganism Circinotrichum falcatisporum RF-641 producing the same and pharmaceutical compositions containing the same are also provided.摘要翻译： 式（I）的化合物，
其中，R <1>，R <2>和R <3>是-COOR <4>，-COOR <5>和-COOR <6>，分别; [R <4> - [R <5>和R <6>各自为氢，低级烷基，或碱金属; W是羟基; X，Y和Z各自是氢或羟基; 虚线表示单键的存在或不存在; 和worin W / R <3>中，X / R <1>，和/或Z / R <3>可以结合在一起，以形成内酯，该化合物是作为磷脂酶A2抑制剂是有用的。 本发明提供一种用于生产化合物（I）的过程中，即，微生物Circinotrichum falcatisporum RF-641生产含有相同的相同的和药物组合物的细胞培养物。 -
公开(公告)号：EP0287110A2
公开(公告)日：1988-10-19
申请号：EP88106040.4
申请日：1988-04-15
发明人： Kondo, Eiji , Kawamura, Yoshimi , Tsuji, Naoki , Matsumoto, Koichi , Kobayashi, Masaaki , Kamigauchi, Toshiyuki , Hayashi, Yoshiyuki , Konishi, Takao
CPC分类号： C07K9/008
摘要： Glycopeptide antibiotics PA-45052 which are produced by Nocardia orientalis PA-45052, show potent activity against gram-positive bacteria, especially against methicillin-resistant bacteria and stimulate growth of animals.
摘要翻译： 由诺卡氏菌PA-45052生产的以下结构的糖肽抗生素PA-45052显示出对革兰氏阳性菌特别是抗甲氧西林抗性细菌的强力活性，并刺激动物的生长。
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