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    TEICOPLANIN ANALOGS AND USES THEREOF
    3.
    发明公开
    TEICOPLANIN ANALOGS AND USES THEREOF 审中-公开
    TEICOPLANINANALALOGA UND VERWENDUNGEN DAVON

    公开(公告)号：EP3099703A4

    公开(公告)日：2017-08-09

    申请号：EP15743950

    申请日：2015-01-26

    申请人： ACAD SINICA

    发明人： LI TSUNG-LIN ,  LYU SYUE-YI ,  LIU YU-CHEN ,  CHANG CHIN-YUAN

    IPC分类号： C07K9/00 ,  A61K38/14

    CPC分类号： C07K9/008 ,  A61K38/00 ,  C12P19/60

    摘要： Described herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting bacterial growth. Methods of using the compounds for treating and/or preventing bacterial infection as well as methods of preparing the compounds are also described.

    摘要翻译： 本文描述了式（I）的化合物或其药学上可接受的盐及其药物组合物。 本发明的化合物可用于抑制细菌生长。 还描述了使用该化合物治疗和/或预防细菌感染的方法以及制备该化合物的方法。

    SEPARATION AND PURIFICATION METHOD FOR VANCOMYCIN HYDROCHLORIDE OF HIGH PURITY
    4.
    发明公开
    SEPARATION AND PURIFICATION METHOD FOR VANCOMYCIN HYDROCHLORIDE OF HIGH PURITY 审中-公开
    TRENTUNG UND VERFAHREN ZUR REINIGUNG VON HOCHREINEM VANCOMYCIN HYDROCHLORID

    公开(公告)号：EP3064214A4

    公开(公告)日：2017-05-03

    申请号：EP14857463

    申请日：2014-10-27

    申请人： ZHEJIANG MED XINCHANG PHARM

    发明人： LI ENMIN ,  ZHUANG YIYUN ,  WANG JUE ,  SUN XINQIANG ,  LAO XUEJUN ,  JIANG BIWANG

    IPC分类号： A61K38/14 ,  C07K1/22 ,  C07K9/00

    CPC分类号： C07K1/36 ,  A61K38/14 ,  C07K1/20 ,  C07K1/34 ,  C07K9/008

    摘要： Provided is a separation and purification method for vancomycin hydrochloride of high purity. The method comprises the following steps: (1) obtaining a vancomycin hydrochloride solution from a crude vancomycin product by ion exchange chromatography and obtaining a concentrate by nanofiltration desalination and concentration; (2) adjusting the concentrate with a hydrochloric acid solution and then performing a column chromatography using a reverse chromatography column for the adjusted concentrate; (3) collecting the chromatographic solution of vancomycin to obtain a mixed chromatographic solution; (4) adjusting the mixed chromatographic solution, and separating the solution and the salts by nanofiltration desalination and concentration to obtain a concentrate; and (5) obtaining a vancomycin dry powder with a chromatographic purity of up to 99% and a pure white appearance by dehydrating and drying the concentrate of step (4), or by solvent crystallization or salting-out crystallization.

    摘要翻译： 提供了一种高纯度万古霉素盐酸盐的分离纯化方法。 该方法包括以下步骤：（1）通过离子交换色谱法从粗品万古霉素产品中获得盐酸万古霉素溶液，并通过纳滤脱盐浓缩得到浓缩液; （2）用盐酸溶液调节浓缩物，然后使用反向色谱柱进行柱层析作为调节浓缩物; （3）收集万古霉素的色谱溶液以获得混合色谱溶液; （4）调整混合的色谱溶液，并通过纳滤脱盐和浓缩分离溶液和盐，得到浓缩物; 和（5）通过脱水和干燥步骤（4）的浓缩物，或者通过溶剂结晶或盐析结晶，获得色谱纯度高达99％和纯白色外观的万古霉素干粉。

    PROCESS FOR THE SYNTHESIS OF TELAVANCIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AS WELL AS N-PROTECTED DERIVATIVES THEREOF
    10.
    发明公开
    PROCESS FOR THE SYNTHESIS OF TELAVANCIN AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS AS WELL AS N-PROTECTED DERIVATIVES THEREOF 审中-公开
    METHOD FOR特拉万星的合成及其盐和N-药学上可接受的保护的衍生物THEREOF

    公开(公告)号：EP2753638A1

    公开(公告)日：2014-07-16

    申请号：EP12759086.7

    申请日：2012-09-07

    申请人： Sandoz AG

    发明人： BENITO-GARAGORRI, David

    IPC分类号： C07K9/00

    CPC分类号： C07K9/008

    摘要： The invention relates to a process for the preparation of telavancin, or a pharmaceutically acceptable salt thereof, wherein said process comprises a reductive alkylation of vancomycin which provides N-protected-decylaminoethylvancomycin, followed by aminomethyiation to obtain N-protected-telavancin, which is then deprotected to provide telavancin, or a pharmaceutically acceptable salt thereof. Another embodiment refers to N-protected-telavancin and pharmaceutically acceptable salts thereof, which are formed during the process of the invention.