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1.发明公开Monoclonal antibody recognizing membrane phospholipase A2 and immunoassay of membrane phospholipase A2 失效认识到膜磷脂酶A2单克隆抗体膜磷脂酶A2和免疫测定法。
公开(公告)号：EP0459450A2
公开(公告)日：1991-12-04
申请号：EP91108806.0
申请日：1991-05-29
发明人： Yoshida, Nobuo , Ide, Misao , Kono, Masao , Kanda, Akiko
IPC分类号： C12P21/08 , C12N5/20 , C12N15/06 , G01N33/573 , G01N33/577
CPC分类号： C07K16/40
摘要： The present invention first provides monoclonal antibodies recognizing membrane phospholipase A₂, namely, monoclonal antibodies PL-49, PL-71, PL-76, and PL-78, hybridomas producing them, methods for producing them, and immunoassays of membrane phospholipase A₂ using them.
The immunoassay of PLA₂M is useful for the diagnosis of articular rheumatism, cancers, and a wide variety of inflammatory states.摘要翻译： 本发明首先提供膜磷脂酶A2，即单克隆抗体PL-49，PL-71，PL-76和PL-78，杂交瘤生产它们，使用它们的膜磷脂酶A2的用于制备它们的方法，和免疫测定确认单克隆抗体 ， PLA2M所述的免疫测定是用于关节风湿病，癌症和各种炎性状态的诊断是有用的。
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公开(公告)号：EP0381433B1
公开(公告)日：1996-10-23
申请号：EP90300937.1
申请日：1990-01-30
发明人： Ishizaki, Jun , Tamaki, Mikio , Shin, Masaru , Teraoka, Hiroshi , Yoshida, Nobuo , Tsuzuki, Hiroshige
CPC分类号： C07K14/57 , C07K14/605 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75
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公开(公告)号：EP0383453B1
公开(公告)日：1994-12-07
申请号：EP90300963.7
申请日：1990-01-30
CPC分类号： C07K14/474 , A61K38/00
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公开(公告)号：EP0398621A2
公开(公告)日：1990-11-22
申请号：EP90305189.4
申请日：1990-05-15
发明人： Yoshida, Nobuo , Inouye, Ken , Kono, Masao
IPC分类号： G01N33/573
CPC分类号： G01N33/573 , G01N33/5306
摘要： This invention provides an immunoassay of elastase-1, which comprises subjecting (a) labelled elastase-1 treated with Boc-TACK and (b) elastase-1 to be measured to competitive reaction with anit-elastase-1 antibody, wherein the Boc-TACK denotes (CH₃)₃COCO[NHCH(CH₃)CO]₃CH₂Cl.
摘要翻译： 本发明提供弹性蛋白酶-1的免疫测定法，其包括：（a）用Boc-TACK处理的标记的弹性蛋白酶-1和（b）弹性蛋白酶-1进行测定以与弹性蛋白酶-1抗体竞争反应，其中Boc- TACK表示（CH3）3COCO [NHCH（CH3）CO] 3CH2Cl。
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5.发明公开Monoclonal antibody recognizing membrane phospholipase A2 and immunoassay of membrane phospholipase A2 失效单克隆抗体识别膜磷脂酶A2和膜磷脂酶A2的免疫
公开(公告)号：EP0459450A3
公开(公告)日：1991-12-11
申请号：EP91108806.0
申请日：1991-05-29
发明人： Yoshida, Nobuo , Ide, Misao , Kono, Masao , Kanda, Akiko
IPC分类号： C12P21/08 , C12N5/20 , C12N15/06 , G01N33/573 , G01N33/577
CPC分类号： C07K16/40
摘要： The present invention first provides monoclonal antibodies recognizing membrane phospholipase A₂, namely, monoclonal antibodies PL-49, PL-71, PL-76, and PL-78, hybridomas producing them, methods for producing them, and immunoassays of membrane phospholipase A₂ using them. The immunoassay of PLA₂M is useful for the diagnosis of articular rheumatism, cancers, and a wide variety of inflammatory states.
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公开(公告)号：EP0369797A3
公开(公告)日：1990-09-12
申请号：EP89311898.4
申请日：1989-11-16
发明人： Okamoto, Hiroshi , Ide, Misao , Yoshida, Nobuo , Teraoka, Hiroshi
IPC分类号： C12P21/08 , G01N33/577 , G01N33/68 , C12N15/23 , C12N15/62
CPC分类号： C07K14/57 , C07K14/474 , C07K16/18 , C07K2319/00 , C07K2319/75
摘要： A monoclonal antibody recognizing a reg protein and a hybridoma producing the monoclonal antibody are provided. Also, methods for the assay of a reg protein using the monoclonal antibody are provided.
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公开(公告)号：EP0383453A1
公开(公告)日：1990-08-22
申请号：EP90300963.7
申请日：1990-01-30
CPC分类号： C07K14/474 , A61K38/00
摘要： A new reg protein is provided. The reg protein has an amino acid sequence beginning with the glutamine residue at the 20th position from the amino terminus and terminating with the asparagine residue at the 165th position in Figure 1, or an amino acid sequence containing an additional methionine residue at the amino terminus of said amino acid sequence extending from the glutamine residue to the asparagine residue.
摘要翻译： 提供了一种新的reg蛋白。 reg蛋白具有从氨基末端开始于第20位的谷氨酰胺残基开始的氨基酸序列，并且终止于图1中第165位的天冬酰胺残基，或在氨基末端含有另外的甲硫氨酸残基的氨基酸序列 所述氨基酸序列从谷氨酰胺残基延伸至天冬酰胺残基。
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公开(公告)号：EP0381433A1
公开(公告)日：1990-08-08
申请号：EP90300937.1
申请日：1990-01-30
发明人： Ishizaki, Jun , Tamaki, Mikio , Shin, Masaru , Teraoka, Hiroshi , Yoshida, Nobuo , Tsuzuki, Hiroshige
CPC分类号： C07K14/57 , C07K14/605 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75
摘要： A novel method for producing glucagon is provided. The method comprises the steps of, preparing a fusion protein shown by the following formula:
X-Glu-Glucagon (I)
wherein X is a leader sequence of 70-170 amino acids, Glu is a glutamic acid residue, and Glucagon represents the amino acid sequence of glucagon, and
treating the fusion protein with an enzyme that specifically hydrolyzes the peptide bonds at the carboxyl termini of the glutamic acid residues, resulting in cleavage of the fusion protein.摘要翻译： 提供了一种生产胰高血糖素的新方法。 该方法包括以下步骤：制备由下式表示的融合蛋白：X-Glu-胰高血糖素（I），其中X是70-170个氨基酸的前导序列，Glu是谷氨酸残基，而胰高血糖素代表氨基 酸性序列，并用特异性水解谷氨酸残基的羧基末端的肽键的酶处理融合蛋白，导致融合蛋白的切割。
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公开(公告)号：EP0482879A3
公开(公告)日：1992-05-20
申请号：EP91309737.4
申请日：1991-10-22
发明人： Teraoka, Hiroshi , Tamaki, Mikio , Nakamura, Etsuo , Shin, Masaru , Yoshida, Nobuo , Tsuzuki, Hiroshige , Fujiwara, Takashi , Matsumoto, Koichi
CPC分类号： C12N9/54
摘要： A novel protease derived from Bacillus licheniformis is provided. The protease cleaves the peptide bonds at the carboxyl termini of glutamic acid residues in polypeptides. The protease contains an amino acid sequence from serine in the +1 position to glutamine in the +222 position of SEQ ID NO: 1.
摘要翻译： 提供了一种来源于地衣芽孢杆菌的新型蛋白酶。 蛋白酶切割多肽中谷氨酸残基羧基末端的肽键。 蛋白酶含有从+1位的丝氨酸到SEQ ID NO：1的+222位的谷氨酰胺的氨基酸序列。
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公开(公告)号：EP0482879A2
公开(公告)日：1992-04-29
申请号：EP91309737.4
申请日：1991-10-22
发明人： Teraoka, Hiroshi , Tamaki, Mikio , Nakamura, Etsuo , Shin, Masaru , Yoshida, Nobuo , Tsuzuki, Hiroshige , Fujiwara, Takashi , Matsumoto, Koichi
CPC分类号： C12N9/54
摘要： A novel protease derived from Bacillus licheniformis is provided. The protease cleaves the peptide bonds at the carboxyl termini of glutamic acid residues in polypeptides. The protease contains an amino acid sequence from serine in the +1 position to glutamine in the +222 position of SEQ ID NO: 1.
摘要翻译： 提供了一种衍生自地衣芽孢杆菌的新型蛋白酶。 蛋白酶切割多肽中谷氨酸残基羧基末端的肽键。 蛋白酶含有从+1位的丝氨酸到SEQ ID NO：1的+222位的谷氨酰胺的氨基酸序列。
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