公开(公告)号：EP1488776A4

公开(公告)日：2005-09-07

申请号：EP03715577

申请日：2003-03-28

申请人： SHISEIDO CO LTD

发明人： HANYU NAOTO ,  KOBAYASHI KOJI ,  TAJIMA MASAHIRO ,  ISHINO AKIHIRO

IPC分类号： A61K8/40 ,  A61K8/41 ,  A61P17/14 ,  A61Q7/00 ,  A61Q19/00 ,  C07C255/42 ,  C07C255/43 ,  A61K7/06

CPC分类号： A61Q19/00 ,  A61K8/40 ,  A61K8/41 ,  A61Q7/00 ,  C07C255/42 ,  C07C255/43

摘要： Hair tonics containing as the active ingredient phenylacetonitrile derivatives represented by the general formula (I) or pharmaceutically acceptable salts thereof: (I) [wherein R and R are each hydrogen, C1-10 alkyl, C2-10 alkenyl, or C2-10 acyl, or NR R may be a 3- to 7-membered heterocycle; R is C1-5 alkyl; and R , R , and R are each hydrogen or C1-4 alkoxy]. The hair tonics of the invention are efficacious in accelerating the growth of human hair and in inhibiting and preventing hair loss by virtue of the specific phenylacetonitrile derivatives contained therein as the active ingredient.

公开(公告)号：EP1352637A4

公开(公告)日：2006-11-02

申请号：EP01272297

申请日：2001-12-21

申请人： SHISEIDO CO LTD

发明人： ISHINO AKIHIRO ,  YOKOYAMA TOMOKO ,  TSUDA TAKANARI ,  HAMADA CHIKA ,  MIZUMOTO DAIGO ,  TAJIMA MASAHIRO

IPC分类号： A61K8/02 ,  A61K8/97 ,  A61P17/00 ,  A61Q7/02 ,  A61Q9/00 ,  A61Q9/02 ,  A61Q19/00 ,  A61K7/155 ,  A61K7/00 ,  A61K7/15 ,  A61K35/78

CPC分类号： A61K8/0212 ,  A61K8/97 ,  A61Q7/02 ,  A61Q9/00 ,  A61Q9/02 ,  A61Q19/00

摘要： Hair growth inhibitors containing as the active ingredients herb drugs selected from among Phellodendron bark, houttuy nia cordata THUNB., rice bran, Morus bombycis KOIDZ., Cop tis rhizome , thyme, Persicae semen, , Pyrola japonica KLENZE, Calendula offcinalis), wild rose and melissa or extracts thereof. Various skin-care compositions for external use such as cosmetics are prepared by mixing these active ingredients with other aqueous phase components and oily phase components in a conventional manner.

摘要翻译： 毛发生长抑制剂含有至少一种选自由黄柏树皮，鱼腥草，米糠，桑树皮，日本黄连，百里香，桃子，荨麻，金盏花，野玫瑰和香草薄荷组成的组的活性成分。 或其提取物和各种皮肤外用施用组合物如用于外皮上的化妆品组合物通过根据常规方法将这些活性成分与其它水相成分和油相成分混合来制备。

公开(公告)号：EP1806121A4

公开(公告)日：2008-03-12

申请号：EP05795223

申请日：2005-10-13

申请人： SHISEIDO CO LTD

发明人： IDETA RITSURO ,  NAKAZAWA YOSUKE ,  IWAKI HARUHI ,  ISHINO AKIHIRO ,  TAJIMA MASAHIRO

IPC分类号： A61K8/00 ,  A61K31/133 ,  A61K31/196 ,  A61K31/215 ,  A61K31/445 ,  A61K31/4465 ,  A61P17/14 ,  A61Q5/00 ,  C07D211/46 ,  C07D211/60

CPC分类号： A61K8/4926 ,  A61K8/44 ,  A61K31/133 ,  A61K31/196 ,  A61K31/215 ,  A61K31/445 ,  A61K31/4465 ,  A61Q5/10

摘要： An anti-graying preparation which contains as an active ingredient a substance having excellent anti-graying activity, e.g., aminocyclohexanecarboxylic acid, an aminocyclohexanecarboxylic acid ester such as ethyl aminocyclohexanecarboxylate, an aminocyclohexane derivative such as aminocyclohexanol, piperidinecarboxylic acid, a piperidinecarboxylic acid ester such as ethyl piperidinecarboxylate, or a piperidine derivative such as hydroxypiperidine.