公开(公告)号：EP0900383B1

公开(公告)日：2003-03-26

申请号：EP97919648.2

申请日：1997-04-23

申请人： SHISEIDO COMPANY LIMITED ,  THE GENERAL HOSPITAL CORPORATION

发明人： MORO, Osamu ,  WAKITA, Kawori ,  HYOCHI, Manami ,  LERNER, Ethan, A. ,  TAJIMA, Masahiro

IPC分类号： G01N33/68 ,  G01N33/567 ,  G01N33/50

CPC分类号： G01N33/6842 ,  A61K38/00 ,  C07K14/47 ,  C07K14/57563 ,  G01N33/68

摘要： This specification relates to use of peptides having a specific affinity to subtype 1 of PACAP (pituitary adenylate cyclase activating polypeptide) receptors, particularly MAX (67 amino acids), NSP (61 amino acids) and M 65 (46 amino acids). MAX and NSP act as agonists to PACAP type 1 receptors, and M 65 acts as an antagonist to PACAP type 1 receptors.

公开(公告)号：EP0900383A1

公开(公告)日：1999-03-10

申请号：EP97919648.0

申请日：1997-04-23

申请人： SHISEIDO COMPANY LIMITED ,  THE GENERAL HOSPITAL CORPORATION

发明人： MORO, Osamu ,  WAKITA, Kawori ,  HYOCHI, Manami ,  LERNER, Ethan, A. ,  TAJIMA, Masahiro

IPC分类号： G01N33 ,  A61K38 ,  C07K14

CPC分类号： G01N33/6842 ,  A61K38/00 ,  C07K14/47 ,  C07K14/57563 ,  G01N33/68

摘要： This specification relates to use of peptides having a specific affinity to subtype 1 of PACAP (pituitary adenylate cyclase activating polypeptide) receptors, particularly MAX (67 amino acids), NSP (61 amino acids) and M 65 (46 amino acids). MAX and NSP act as agonists to PACAP type 1 receptors, and M 65 acts as an antagonist to PACAP type 1 receptors.

公开(公告)号：EP1001677A1

公开(公告)日：2000-05-24

申请号：EP98906072.8

申请日：1998-02-03

申请人： THE GENERAL HOSPITAL CORPORATION

发明人： LERNER, Ethan, A. ,  QURESHI, Abrar, A. ,  LERNER, Lisa, H.

IPC分类号： A01N37/12 ,  A01N37/44

CPC分类号： A61K8/64 ,  A61K31/00 ,  A61K31/223 ,  A61K31/295 ,  A61K33/26 ,  A61Q19/02

摘要： A method of treating a subject for an unwanted epidermal or dermal condition comprising administering to the subject a treatment which modulates the level of nitric oxide (NO) in the skin.

公开(公告)号：EP0683660A1

公开(公告)日：1995-11-29

申请号：EP94909527.0

申请日：1994-02-10

申请人： SHISEIDO COMPANY LIMITED ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE

发明人： RIBEIRO, Jose, M., C. ,  LERNER, Ethan, A. ,  REMOLD, Heinz, G. ,  TITUS, Richard, G. ,  TSUJI, Yoshiharu, The Shiseido Research Center ,  HANSAWA, Chika, The Shiseido Research Center ,  UZUKA, Makoto, The Shiseido Research Center

IPC分类号： C07H21 ,  A61K8 ,  A61K35 ,  A61K38 ,  A61P43 ,  A61Q5 ,  A61Q7

CPC分类号： A61K8/64 ,  A61K2800/91 ,  A61Q7/00

摘要： The present invention relates to a method for the enhancement of hair growth and to topical compositions suitable for use in the method. Peptides that can be found in the salivary glands of the sand fly Lutzomyia longipalpis, exemplified by maxadilan, are utilized for the enhancement of hair growth and the prevention of epilation and trichogenous effects.