公开(公告)号：EP0858803A1

公开(公告)日：1998-08-19

申请号：EP96927914.0

申请日：1996-08-27

申请人： Showa Yakuhin Kako Co. Ltd

发明人： HARAGUCHI, Mitsuhiro, Showa Yakuhin Kako Co., Ltd. ,  ONO, Kazuhiro, Showa Yakuhin Kako Co., Ltd. ,  OSADA, Takashi, Showa Yakuhin Kako Co., Ltd. ,  SUZUKI, Yukio, Showa Yakuhin Kako Co., Ltd.

IPC分类号： A61K31/165 ,  A61K47/12

CPC分类号： A61K9/0019 ,  A61K31/19 ,  A61K31/195 ,  A61K47/183 ,  Y10S514/817 ,  Y10S514/818 ,  Y10S514/97 ,  A61K31/165 ,  A61K31/135 ,  A61K2300/00

摘要： A composition for local anesthesia which comprises (A) lidocaine, (B) a catecholamine such as epinephrine in an amount of, for example, 1/200,000 (g/ml) based on the volume of the composition, and (C) one or more amino acids such as glycine, glutamic acid, and L-glutamic acid-L-lysine or one or more hydroxycarboxylic acids such as lactic acid, glycolic acid, and citric acid, which has a duration suitable for short-time dental operations such as tooth extraction and excellent storage stability.

摘要翻译： 一种用于局部麻醉的组合物，其包含（A）基于组合物体积的（A）利多卡因，（B）儿茶酚胺如肾上腺素，其量例如为1 / 200,000（g / ml），和（C） 更多的氨基酸如甘氨酸，谷氨酸和L-谷氨酸-L-赖氨酸或一种或多种羟基羧酸如乳酸，乙醇酸和柠檬酸，其具有适合于短时间牙科操作的持续时间，例如 牙齿提取和优良的储存稳定性。

公开(公告)号：EP0933084A1

公开(公告)日：1999-08-04

申请号：EP95942284.1

申请日：1995-12-27

申请人： SHOWA YAKUHIN KAKO CO., LTD.

发明人： SHIMA, Junko, Showa Yakuhin Kako Co., Ltd. ,  ONO, Kazuhiro, Showa Yakuhin Kako Co., Ltd. ,  OSADA, Takashi, Showa Yakuhin Kako Co., Ltd. ,  SUZUKI, Yukio, Showa Yakuhin Kako Co., Ltd.

IPC分类号： A61K47/18

CPC分类号： A61K9/0019 ,  A61K9/0048 ,  A61K47/18 ,  A61K47/186 ,  A61K47/22

摘要： An aqueous pharmaceutical composition comprising sodium cromoglicate as an active ingredient and a quaternary ammonium compound such as benzalkonium chloride as a preservative, characterized in that said composition comprises a precipitation inhibitor selected from the group consisting of alkanolamines including 2-aminoethanol and tocopherols including d-α-tocopherol is provided. The composition has characteristic feature of free from precipitation or turbidity in manufacturing processes and during storage.

摘要翻译： 一种包含色甘酸钠作为活性成分的水性药物组合物和季铵化合物如苯扎氯铵作为防腐剂，其特征在于所述组合物包含选自包括2-氨基乙醇的链烷醇胺和包括d-α的生育酚的沉淀抑制剂 - 生育酚。 该组合物具有在制造过程中和储存期间没有沉淀或浊度的特征。