专利检索 ap:("SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.") AND inv:"BADALONI, Elena" 第 1 页

1.

发明授权
CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM 有权
标题翻译： 7-（二甲氧基甲基）晶型II的 - 喜树碱和中间体USE THEREOF，与产品获得

公开(公告)号：EP2170900B1

公开(公告)日：2012-12-12

申请号：EP08786333.8

申请日：2008-07-22

申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.

发明人： CABRI, Walter , MARZI, Mauro , GIORGI, Fabrizio , BADALONI, Elena , ARMAROLI, Silvia , MARAZZI, Giuseppe

IPC分类号： C07D491/22

CPC分类号： C07D491/22

2.

发明公开
CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM 有权
标题翻译： 7-（二甲氧基甲基）晶型II的 - 喜树碱和中间体USE THEREOF，与产品获得

公开(公告)号：EP2170900A1

公开(公告)日：2010-04-07

申请号：EP08786333.8

申请日：2008-07-22

申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A.

发明人： CABRI, Walter , MARZI, Mauro , GIORGI, Fabrizio , BADALONI, Elena , ARMAROLI, Silvia , MARAZZI, Giuseppe

IPC分类号： C07D491/22

CPC分类号： C07D491/22

摘要： This invention relates to a process for preparing a crystalline form of (4S)-11-(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]qui-no line-3,14(4H,12H)-dione (also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing it from methanol.