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1.发明公开AMINOOXIME DERIVATIVES OF 2- AND/OR 4-SUBSTITUTED ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS 有权作者2-和/或AMINOOXISOMDERIVATE 4-取代的雄甾烷和ANDROSTENEN AS DRUGS预防心脏病CYCLE
公开(公告)号：EP2209795A1
公开(公告)日：2010-07-28
申请号：EP08804418.5
申请日：2008-09-18
发明人： CERRI, Alberto , BIANCHI, Giuseppe , FEDRIZZI, Giorgio , FERRARI, Patrizia , GOBBINI, Mauro , MARAZZI, Giuseppe , TORRI, Marco , CABRI, Walter
CPC分类号： C07J41/0016 , C07J43/003
摘要： New aminooxime derivatives at position 3 of 2-and/or 4-substituted androstanes and androstenes, processes for their preparation, and to pharmaceutical compositions containing them for the treatment of cardiovascular disorders, such as heart failure and hypertension. In particular compounds having the general formula (I) are described,where the radicals have the meanings described in detail in the application.
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2.发明授权CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM 有权7-（二甲氧基甲基）晶型II的 - 喜树碱和中间体USE THEREOF，与产品获得
公开(公告)号：EP2170900B1
公开(公告)日：2012-12-12
申请号：EP08786333.8
申请日：2008-07-22
发明人： CABRI, Walter , MARZI, Mauro , GIORGI, Fabrizio , BADALONI, Elena , ARMAROLI, Silvia , MARAZZI, Giuseppe
IPC分类号： C07D491/22
CPC分类号： C07D491/22
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3.发明授权AMINOOXIME DERIVATIVES OF 2- AND/OR 4-SUBSTITUTED ANDROSTANES AND ANDROSTENES AS MEDICAMENTS FOR CARDIOVASCULAR DISORDERS 有权作者2-和/或AMINOOXISOMDERIVATE 4-取代的雄甾烷和ANDROSTENEN AS DRUGS预防心脏病CYCLE
公开(公告)号：EP2209795B1
公开(公告)日：2013-04-24
申请号：EP08804418.5
申请日：2008-09-18
发明人： CERRI, Alberto , BIANCHI, Giuseppe , FEDRIZZI, Giorgio , FERRARI, Patrizia , GOBBINI, Mauro , MARAZZI, Giuseppe , TORRI, Marco , CABRI, Walter
CPC分类号： C07J41/0016 , C07J43/003
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4.发明公开CRYSTALLINE FORM II OF 7-(DIMETHOXY-METHYL) CAMPTOTHECIN, ITS USE AS INTERMEDIATE AND PRODUCTS OBTAINED THEREFROM 有权7-（二甲氧基甲基）晶型II的 - 喜树碱和中间体USE THEREOF，与产品获得
公开(公告)号：EP2170900A1
公开(公告)日：2010-04-07
申请号：EP08786333.8
申请日：2008-07-22
发明人： CABRI, Walter , MARZI, Mauro , GIORGI, Fabrizio , BADALONI, Elena , ARMAROLI, Silvia , MARAZZI, Giuseppe
IPC分类号： C07D491/22
CPC分类号： C07D491/22
摘要： This invention relates to a process for preparing a crystalline form of (4S)-11-(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]qui-no line-3,14(4H,12H)-dione (also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing it from methanol.
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