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1.发明授权NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS 有权与内酰胺作为强有力的HDAC抑制剂新型含硫衍生物及其用途，因为药物
公开(公告)号：EP2758371B1
公开(公告)日：2016-06-15
申请号：EP12761967.4
申请日：2012-09-17
发明人： GIANNINI, Giuseppe , CABRI, Walter , BATTISTUZZI, Gianfranco , VIGNOLA, Davide , FANTO', Nicola , PISANO, Claudio , VESCI, Loredana
IPC分类号： C07D205/08 , C07D207/277 , C07D207/28 , C07D211/78 , C07D401/04 , A61K31/397 , A61K31/4015 , A61K31/45 , A61K31/4709 , A61P25/00 , A61P29/00 , A61P33/00 , A61P35/00
CPC分类号： C07D213/69 , C07D205/08 , C07D207/277 , C07D207/28 , C07D207/46 , C07D211/78 , C07D211/94 , C07D401/04 , C07D401/12
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2.发明公开NEW THIO DERIVATIVES BEARING LACTAMS AS POTENT HDAC INHIBITORS AND THEIR USES AS MEDICAMENTS 有权与内酰胺作为强有力的HDAC抑制剂新型含硫衍生物及其用途，因为药物
公开(公告)号：EP2758371A1
公开(公告)日：2014-07-30
申请号：EP12761967.4
申请日：2012-09-17
发明人： GIANNINI, Giuseppe , CABRI, Walter , BATTISTUZZI, Gianfranco , VIGNOLA, Davide , FANTO', Nicola , PISANO, Claudio , VESCI, Loredana
IPC分类号： C07D205/08 , C07D207/277 , C07D207/28 , C07D211/78 , C07D401/04 , A61K31/397 , A61K31/4015 , A61K31/45 , A61K31/4709 , A61P25/00 , A61P29/00 , A61P33/00 , A61P35/00
CPC分类号： C07D213/69 , C07D205/08 , C07D207/277 , C07D207/28 , C07D207/46 , C07D211/78 , C07D211/94 , C07D401/04 , C07D401/12
摘要： The present invention relates to novel amide compounds of Formula (I), and their use as anti-tumoral and pro-apoptotic agents. The invention includes the use of such compounds in medicine, in relation to cancer disease as well as other diseases where an inhibition of HDAC is responsive, and the pharmaceutical composition containing such compounds.
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