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    PYRROLIDONE DERIVATIVES, OLIGOMERS AND POLYMERS
    2.
    发明公开
    PYRROLIDONE DERIVATIVES, OLIGOMERS AND POLYMERS 审中-公开

    公开(公告)号：EP3194365A4

    公开(公告)日：2018-04-25

    申请号：EP15839322

    申请日：2015-09-14

    申请人： NANOSYNTHONS LLC

    发明人： TOMALIA DONALD A ,  HEDSTRAND DAVID M ,  NIXON LINDA S

    IPC分类号： C07D207/28 ,  C07D207/277

    CPC分类号： A61K49/0021 ,  C07D207/277 ,  C07D207/28 ,  C07D403/14 ,  C09B13/00

    摘要： Simple organic structures, organic/inorganic polymers, and other substrates have been made, all of which have at least one pyrrolidone moiety present, and found to exhibit low toxicity, low complement activation features and may be used to reduce protein interactions with drug conjugates while enhancing in vivo residency times for these conjugates when used as an injectable composition; thus these compounds can be used as substitutes for PEG in PEGaylation. Surprisingly, these compounds also exhibit unique intrinsic fluorescence (IF) or non-traditional fluorescence (NTF) properties that currently cannot be explained by traditional photochemistry and fluorescence paradigms are described. These compounds have a variety of applications such as in cellular imaging, gene transfection, bio-diagnostics, biosensing, fluorescence directed surgical resections, drug delivery, forensics, environmental diagnostics, mineral/gemstone characterization, counterfeit goods detection, tracer studies related to liquid/water flow, oil field enhancements and diagnostics, prevention of photo-bleaching, and LED display enhancements and others.

    LACTAMS
    10.
    发明公开
    LACTAMS 审中-公开
    内酰胺

    公开(公告)号：EP1140821A1

    公开(公告)日：2001-10-10

    申请号：EP99959602.6

    申请日：1999-12-14

    申请人： ISIS INNOVATION LIMITED

    发明人： SCHOFIELD, Christopher Joseph,Dyson Perrins Lab.

    IPC分类号： C07D207/26 ,  C07D207/28 ,  C07D207/48 ,  C07D211/74 ,  C07D211/78 ,  A61K31/4015 ,  A61P11/00

    CPC分类号： C07D207/277 ,  C07D207/28 ,  C07D207/48 ,  C07D211/74 ,  C07D211/78

    摘要： A compound of formula (I) wherein R1 is hydrogen or an electron withdrawing group; one of X1 to X4 is a CR2R3 group wherein at least one of R?2 and R3 is C1 to C¿6 aliphatic group, an aromatic group, a heterocyclic group, a basic group or R4CONH wherein R4 is a C¿1? to C6 aliphatic group, an aromatic group or a heterocyclic group and any remaining R?2 or R3¿ is hydrogen; at least one of X1 to X4 is a CHR5 group wherein R5 comprises a hydrogen bond donor or acceptor; the remaining X1 to X4 groups are CH¿2?, O or NR?6¿ wherein R6 is hydrogen, a C¿1? to C6 aliphatic group, an aromatic group or a heterocyclic group; and y is 0 or 1, or a pharmaceutically acceptable salt thereof.