公开(公告)号：EP1656380A2

公开(公告)日：2006-05-17

申请号：EP04745199.2

申请日：2004-07-06

申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. ,  ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： GIANNINI, Giuseppe Simgma-Tau Industrie Farmaceut. ,  PENCO, Sergio ,  TINTI, Maria, Ornella Simgma-Tau Industrie Farma. ,  PISANO, Claudio c/o Simgma-Tau Industrie Farmaceut ,  VESCI, Loredana c/o Simgma-Tau Industrie Farmaceut ,  MERLINI, Lucio c/o Simgma-Tau Industrie Farmaceut. ,  ZUNINO, Franco c/o Istituto Nazionale per lo

IPC分类号： C07D491/22

CPC分类号： C07D491/22 ,  Y02P20/55

摘要： Compounds are disclosed with the general formula (I) in which the groups are as defined in the description here below and characterized by the presence of polyamine substituents on the imine/oxime residue, such amine groups being in turn protected by suitable protective groups. Said compounds are endowed with potent topoisomerase I inhibiting activity and therefore are useful as medicaments for the treatment of tumours and viral and parasite infections.

摘要翻译： 公开了具有通式（I）的化合物，其中基团如下面的描述中所定义，并且特征在于亚胺/肟残基上存在多胺取代基，这些胺基团又被合适的保护基团保护。 所述化合物具有有效的拓扑异构酶I抑制活性，因此可用作治疗肿瘤和病毒和寄生虫感染的药物。