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公开(公告)号：EP2112154B1
公开(公告)日：2013-07-24
申请号：EP09162737.2
申请日：2003-05-28
申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. , Istituto Nazionale Per Lo Studio E La Cura Dei Tumori
发明人： Marzi, Mauro , Alloatti, Domenico , Pisano, Claudio , Tinti, Maria Ornella , Vesci, Loredana , Zunino, Franco
IPC分类号： C07D491/22 , A61K31/4375 , A61P35/00 , A61P31/12 , A61P33/00
CPC分类号： C07D491/22
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公开(公告)号：EP2112154A1
公开(公告)日：2009-10-28
申请号：EP09162737.2
申请日：2003-05-28
申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. , Istituto Nazionale Per Lo Studio E La Cura Dei Tumori
发明人： Marzi, Mauro , Alloatti, Domenico , Pisano, Claudio , Tinti, Maria Ornella , Vesci, Loredana , Zunino, Franco
IPC分类号： C07D491/22 , A61K31/4375 , A61P35/00 , A61P31/12 , A61P33/00
CPC分类号： C07D491/22
摘要： Formula (I) compounds are described:
where the groups are as defined in the description here below, the racemic mixtures, their individual enantiomers, their individual diastereoisomers, their mixtures, and their pharmaceutically acceptable salts. Said compounds are topoisomerase I inhibitors.摘要翻译： 描述式（I）化合物：其中基团如下文所述的定义，外消旋混合物，其各自的对映异构体，其各自的非对映异构体，其混合物及其药学上可接受的盐。 所述化合物是拓扑异构酶I抑制剂。
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3.发明授权Use of esters of L-carnitine or alkanoyl L-carnitines as cationic lipids for the intracellular delivery of pharmacologically active compounds 有权用作阳离子脂质的L-肉碱的酸或烷酰基L-肉碱酸的酯的用于治疗物质的细胞内递送
公开(公告)号：EP1426044B1
公开(公告)日：2006-02-08
申请号：EP03020049.7
申请日：2000-04-11
发明人： Pisano, Claudio , Tinti, Maria Ornella , Santaniello, Mosè , Critelli, Luciana , Salvatori, Giovanni
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： The use of esters of L-carnitine and alkanoyl L-carnitines as cationic lipids for the intracellular delivery of pharmacologically active compounds is described. The esters according to the invention have general formula (II) wherein the R groups are as defined in the description.
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4.发明公开Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds 审中-公开L-肉碱或链烷酰基L-肉毒碱的酯用于制备阳离子脂质的对药理活性的化合物的细胞内递送
公开(公告)号：EP1435232A1
公开(公告)日：2004-07-07
申请号：EP04006990.8
申请日：2000-04-11
发明人： Pisano, Claudio , Tinti, Maria Ornella , Santaniello, Mosé , Critelli, Luciana , Salvatori, Giovanni
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： Esters of L-carnitine and alkanoyl L-carnitines are described which can be used as cationic lipids for the intracellular delivery of pharmacologically active compounds.
摘要翻译：
L-肉碱和链烷酰基L-肉碱中描述了可以用作阳离子脂质为药理学活性化合物的细胞内递送的酯。 -
5.发明公开Use of esters of L-carnitine or alkanoyl L-carnitines as cationic lipids for the intracellular delivery of pharmacologically active compounds 有权用作阳离子脂质的L-肉碱的酸或烷酰基L-肉碱酸的酯的用于治疗物质的细胞内递送
公开(公告)号：EP1426044A1
公开(公告)日：2004-06-09
申请号：EP03020049.7
申请日：2000-04-11
发明人： Pisano, Claudio , Tinti, Maria Ornella , Santaniello, Mosè , Critelli, Luciana , Salvatori, Giovanni
CPC分类号： C07C229/22 , A61K8/14 , A61K8/44 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K9/1277 , A61K9/19 , A61K31/225 , A61K48/00 , A61Q19/00
摘要： The use of esters of L-carnitine and alkanoyl L-carnitines as cationic lipids for the intracellular delivery of pharmacologically active compounds is described. The esters according to the invention have general formula (II)
wherein the R groups are as defined in the description.摘要翻译： 使用L-肉碱和链烷酰基L-肉碱作为阳离子脂质为药理学活性化合物的细胞内递送的酯进行说明。 酯gemäß发明具有通式（II）
worin R基团是如说明书中所定义。
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