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1.发明公开LITHIUM-POROUS METAL OXIDE COMPOSITIONS AND LITHIUM REAGENT-POROUS METAL COMPOSITIONS 有权基于锂与多孔金属和组合物组合物基于锂试剂与多孔金属
公开(公告)号：EP2081682A2
公开(公告)日：2009-07-29
申请号：EP07814783.2
申请日：2007-09-10
CPC分类号： C07F1/02 , C01C1/026 , C01D15/00 , C01P2002/86 , C01P2002/87 , C01P2002/89 , C01P2006/16 , Y02P20/52
摘要： The invention relates to lithium metal/porous metal oxide compositions. These lithium metal compositions are prepared by mixing liquid lithium metal with a porous metal oxide in an inert atmosphere under exothermic conditions sufficient to absorb the liquid lithium metal into the porous metal oxide pores. The lithium metal/porous metal oxide compositions of the invention are preferably loaded with lithium metal up to about 40% by weight, with about 20% to 40% by weight being the most preferred loading. The invention also relates to lithium reagent-porous metal oxide compositions having RLi absorbed into a porous oxide. In formula RLi, R is an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an alkaryl group, or an NR1R2 group; R1 is an alkyl group, an alkenyl group, an alkynyl group, an aryl group, an alkaryl group; and R2 is hydrogen, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, and an alkaryl group. The preparation and use of these compositions are also described.
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2.发明公开METHOD FOR DEPROTECTING ARYL OR ALKYL SULFONAMIDES OF PRIMARY OR SECONDARY AMINES 审中-公开脱保护的芳基或烷基磺酰胺从伯或仲胺的方法
公开(公告)号：EP2035465A2
公开(公告)日：2009-03-18
申请号：EP07750696.2
申请日：2007-02-13
申请人： SIGNA CHEMISTRY LLC
IPC分类号： C08F2/46
CPC分类号： C07D211/96 , C07C209/62 , C07C213/08 , C07C2601/14 , Y02P20/55 , C07C211/35 , C07C211/40 , C07C211/45 , C07C217/08
摘要： The invention relates to a method for removing an alkyl sulfonyl or aryl sulfonyl protecting group from a primary or secondary amine by contacting an alkyl sulfonamide or an aryl sulfonamide with a Stage 0 or Stage I alkali metal - silica gel material in the presence of a solid proton source under conditions sufficient to form the corresponding amine. The invention also relates to a method for removing an alkyl sulfonyl or aryl sulfonyl protecting group from a primary or secondary amine by a) reacting an alkyl sulfonamide or an aryl sulfonamide with a Stage 0 or Stage I alkali metal - silica gel material, and b) subsequently reacting the reaction product from step a) with an electrophile or a proton source. Preferred Stage 0 or Stage I alkali metal - silica gel materials include Na, K2Na, and Na2K.
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