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    POLYMETAL HYDROXYCHLORIDE PROCESSES AND COMPOSITIONS: ENHANCED EFFICACY ANTIPERSPIRANT SALT COMPOSITIONS
    4.
    发明公开
    POLYMETAL HYDROXYCHLORIDE PROCESSES AND COMPOSITIONS: ENHANCED EFFICACY ANTIPERSPIRANT SALT COMPOSITIONS 有权
    槲皮素甙

    公开(公告)号：EP1981808A2

    公开(公告)日：2008-10-22

    申请号：EP07717247.6

    申请日：2007-01-04

    申请人： Next Chem ,  Pratt, William E. ,  Stevens, Joseph J.

    发明人： PRATT, William, E. ,  STEVENS, Joseph, J.

    IPC分类号： C01B9/00 ,  C01B9/02

    CPC分类号： C01F7/56 ,  A61K8/26 ,  A61K8/28 ,  A61K8/44 ,  A61Q15/00 ,  B01D61/44 ,  C01B7/035 ,  C01G25/006 ,  C01P2002/87

    摘要： The invention describes processes for the production of basic aluminum compounds, including aluminum chlorohydrate, basic zirconium compounds, and basic aluminum zirconium compounds. The process produces products of a wide range of basicities. The products formed by the present invention are comprised of low molecular weight species characteristic of enhanced efficacy antiperspirant salt compositions. The products of this process are suitable for use as water purification agents, as binders in catalyst applications, and in antiperspirant applications. In addition, the invention is directed to the products made by the disclosed process.

    摘要翻译： 本发明描述了生产碱性铝化合物的方法，包括氯化铝水合物，碱性锆化合物和碱性锆锆化合物。 该过程产生广泛基础的产品。 由本发明形成的产品由具有增强功效的止汗剂组合物特征的低分子量物质组成。 该方法的产品适用于作为水净化剂，作为催化剂应用中的粘合剂和止汗剂应用。

    Method of preparing rhenium-188 tricarbonyl triaqua complex
    5.
    发明公开
    Method of preparing rhenium-188 tricarbonyl triaqua complex 有权
    冯·铼188号的Verfahren zur Herstellung des Tricarbonyltriaquakomplexes

    公开(公告)号：EP1797904A1

    公开(公告)日：2007-06-20

    申请号：EP06076412.3

    申请日：2006-07-13

    申请人： Korea Atomic Energy Research Institute

    发明人： Park, Sang Hyun ,  Byun, Myung Woo ,  Jang, Seung Ho

    IPC分类号： A61K51/02 ,  C07F13/00

    CPC分类号： C01G47/00 ,  A61K51/0402 ,  A61K51/0474 ,  A61K51/0476 ,  A61K51/1282 ,  C01G47/003 ,  C01P2002/87

    摘要： Disclosed herein is a method of preparing a 188 Retricarbonyl complex for radiopharmaceutical use and of preparing a precursor thereof, and a contrast agent using the same. Particularly, this invention provides a method of preparing a 188 Re-tricarbonyl precursor by reacting perrhenate with borane·ammonia (BH 3 ·NH 3 ), potassium boranocarbonate (K 2 [H 3 BCO 2 ]) and phosphate in the presence of borohydride exchange resin as a reducing agent, and a method of preparing a 188 Re-tricarbonyl complex by reacting the 188 Re-tricarbonyl precursor with a ligand. According to the method of this invention, the borohydride exchange resin is used as a reducing agent and as an anion scavenger, thereby obtaining the 188 Re-tricarbonyl precursor and complex having high radiolabeling yield and high purity. In addition, the 188 Re-tricarbonyl complex can be used as a contrast agent having excellent plasma stability.

    摘要翻译： 本文公开了一种制备188用于放射性药物用途的Retararbonyl络合物和制备其前体的方法，以及使用其的造影剂。 特别地，本发明提供了一种通过在硼氢化物交换剂存在下使高铼酸盐与硼烷·氨（BH 3·NH 3），硼烷碳酸钾（K 2 [H 3 BCO 2]）和磷酸盐反应制备188-三羰基前体的方法 树脂作为还原剂，以及通过使188重氮三羰基前体与配体反应制备188重复三羰基络合物的方法。 根据本发明的方法，使用硼氢化物交换树脂作为还原剂和阴离子清除剂，从而得到188重复三羰基前体和具有高放射性标记产率和高纯度的复合物。 此外，188重复三羰基复合物可以用作具有优异的等离子体稳定性的造影剂。

    ALUMINUM-ZIRCONIUM ANTIPERSPIRANT SALTS WITH HIGH PEAK 5 Al CONTENT
    6.
    发明授权
    ALUMINUM-ZIRCONIUM ANTIPERSPIRANT SALTS WITH HIGH PEAK 5 Al CONTENT 有权
    锆铝ANTIPERPSPIRANZ盐类

    公开(公告)号：EP1330232B1

    公开(公告)日：2006-08-16

    申请号：EP01988579.7

    申请日：2001-10-24

    申请人： The Gillette Company

    发明人： CARRILLO, Angel, L. ,  ORYSZCZAK, Richard ,  SHEN, Yan-Fei

    IPC分类号： A61K8/28 ,  A61K8/44 ,  A61Q15/00 ,  C01F7/00 ,  C01F7/56 ,  C01F7/48 ,  C01F7/66 ,  C01G25/00

    CPC分类号： A61Q15/00 ,  A61K8/28 ,  C01G25/006 ,  C01P2002/87 ,  Y10S424/05

    摘要： Disclosed are enhanced efficacy aluminum-zirocnium antiperspirant salt compositions which exhiit an HPLC peak 5 area content of about 33 % or more, preferably at least 45 %, more preferably at least 50 %, most preferably at least 55 %. Especially preferred are aluminum-zirconium antiperspirant salt composition which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al + Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant sald compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminium-zirconium antiperspirant salt composition as described above.