公开(公告)号：EP1363891A2

公开(公告)日：2003-11-26

申请号：EP02720975.8

申请日：2002-02-13

申请人： SIGNAL PHARMACEUTICALS, INC.

发明人： SAKATA, Steven, T. ,  RAYMON, Heather, K.

IPC分类号： C07D275/04 ,  A61K31/425 ,  A61P43/00 ,  C07D417/12

CPC分类号： C07D275/04 ,  C07D417/12

摘要： Isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones, and derivatives thereof having the general formula (VI), and pharmaceutically acceptable salts thereof, wherein R0 is -CH2-, -SO-, -O-, -SO2-, or -S-; compositions comprising the isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones, and derivatives thereof; and methods for treating or preventing a disorder alleviated by inhibiting Jun N-terminal kinase (JNK) by administering the isothiazoloanthrones, isoxazoloanthrones, isoindolanthrones, and derivatives thereof are described herein.

公开(公告)号：EP1105464A1

公开(公告)日：2001-06-13

申请号：EP99941107.7

申请日：1999-08-12

申请人： SIGNAL PHARMACEUTICALS, INC.

发明人： SAH, Dinah, W. ,  RAYMON, Heather, K.

IPC分类号： C12N5/10 ,  A61K48/00

CPC分类号： C12N5/0623 ,  A61K35/12 ,  A61K48/00 ,  C12N2501/115 ,  C12N2503/02 ,  C12N2510/04

摘要： Conditionally-immortalized human mesencephalon cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons, including dopaminergic neurons. The cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of neurological diseases such as Parkinson's disease. The cell lines and/or differentiated cells may also be used in assays and for the general study of mesencephalon cell development and differentiation.

公开(公告)号：EP1071750A1

公开(公告)日：2001-01-31

申请号：EP99918545.7

申请日：1999-04-14

申请人： SIGNAL PHARMACEUTICALS, INC.

发明人： SAH, Dinah, W. Y. ,  RAYMON, Heather, K.

IPC分类号： C12N5/06 ,  C12N5/10 ,  C12N15/86 ,  G01N33/50 ,  A61K48/00 ,  C12Q1/68

CPC分类号： C07K14/82 ,  C12N5/0623 ,  C12N2503/00 ,  C12N2510/04 ,  C12N2740/13043 ,  G01N33/5058

摘要： Conditionally-immortalized PNS progenitor cell lines are provided. Such cell lines, which may be clonal, may be used to generate neurons. The cell lines and/or differentiated cells may be used for the development of therapeutic agents to prevent and treat a variety of PNS-related diseases. The cell lines and/or differentiated cells may also be used in assays and for the general study of PNS cell development, death and abnormalities.