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1.发明授权RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) 有权通过使用新浪基因表达的RNA干扰介导的抑制（短干扰核酸）
公开(公告)号：EP1423406B2
公开(公告)日：2015-11-25
申请号：EP03743684.7
申请日：2003-02-20
发明人： MCSWIGGEN, James , BEIGELMAN, Leonid , CHOWRIRA, Bharat , PAVCO, Pamela , FOSNAUGH, Kathy , JAMISON, Sharon , USMAN, Nassim , THOMPSON, James
CPC分类号： C12N15/8218 , A61K38/00 , A61K47/54 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/344 , C12N2310/346 , C12N2310/53 , C12N2320/51 , C12N2330/30 , Y02A50/393 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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2.发明授权RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING CHEMICALLY MODIFIED SHORT INTERFERING NUCLEIC ACID 有权RNA干扰介导的基因表达的抑制使用化学修饰的短干扰核酸
公开(公告)号：EP1458741B1
公开(公告)日：2012-10-17
申请号：EP03716126.2
申请日：2003-02-20
发明人： McSWIGGEN, James , BEIGELMAN, Leonid , MACEJAK, Dennis , ZINNEN, Shawn , PAVCO, Pamela , MORRISSEY, David , FOSNAUGH, Kathy , MOKLER, Victor , JAMISON, Sharon
CPC分类号： C12N15/8218 , A61K38/00 , A61K47/54 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/344 , C12N2310/346 , C12N2310/53 , C12N2320/51 , C12N2330/30 , Y02A50/393 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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3.发明公开
公开(公告)号：EP3926046A3
公开(公告)日：2022-03-23
申请号：EP21166750.6
申请日：2003-02-20
发明人： MCSWIGGEN, James , BEIGELMAN, Leonid , CHOWRIRA, Bharat , PAVCO, Pamela , FOSNAUGH, Kathy , JAMISON, Sharon , USMAN, Nassim , THOMPSON, James
IPC分类号： C12N15/11 , C12N15/85 , C12N15/86 , C12Q1/68 , A61K48/00 , C12P19/34 , C07H21/02 , C07H21/04
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), doublestranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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4.发明公开
公开(公告)号：EP3926046A2
公开(公告)日：2021-12-22
申请号：EP21166750.6
申请日：2003-02-20
发明人： MCSWIGGEN, James , BEIGELMAN, Leonid , CHOWRIRA, Bharat , PAVCO, Pamela , FOSNAUGH, Kathy , JAMISON, Sharon , USMAN, Nassim , THOMPSON, James
IPC分类号： C12N15/11 , C12N15/85 , C12N15/86 , C12Q1/68 , A61K48/00 , C12P19/34 , C07H21/02 , C07H21/04
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), doublestranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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5.发明授权RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) 有权RNA介导的干扰介导的短基因干扰抑制基因表达（SINA）
公开(公告)号：EP2902406B1
公开(公告)日：2018-01-31
申请号：EP14195627.6
申请日：2003-02-20
发明人： MCSWIGGEN, James , BEIGELMAN, Leonid , CHOWRIRA, Bharat , PAVCO, Pamela , FOSNAUGH, Kathy , JAMISON, Sharon , USMAN, Nassim , THOMPSON, James
CPC分类号： C12N15/8218 , A61K38/00 , A61K47/54 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/344 , C12N2310/346 , C12N2310/53 , C12N2320/51 , C12N2330/30 , Y02A50/393 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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6.发明公开
公开(公告)号：EP3354656A1
公开(公告)日：2018-08-01
申请号：EP17209752.9
申请日：2003-02-20
发明人： MCSWIGGEN, James , BEIGELMAN, Leonid , CHOWRIRA, Bharat , PAVCO, Pamela , FOSNAUGH, Kathy , JAMISON, Sharon , USMAN, Nassim , THOMPSON, James
CPC分类号： C12N15/8218 , A61K38/00 , A61K47/54 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/344 , C12N2310/346 , C12N2310/53 , C12N2320/51 , C12N2330/30 , Y02A50/393 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), doublestranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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7.发明授权RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) 有权通过使用新浪基因表达的RNA干扰介导的抑制（短干扰核酸）
公开(公告)号：EP1423406B1
公开(公告)日：2010-09-01
申请号：EP03743684.7
申请日：2003-02-20
发明人： MCSWIGGEN, James , BEIGELMAN, Leonid , CHOWRIRA, Bharat , PAVCO, Pamela , FOSNAUGH, Kathy , JAMISON, Sharon , USMAN, Nassim , THOMPSON, James
CPC分类号： C12N15/8218 , A61K38/00 , A61K47/54 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/344 , C12N2310/346 , C12N2310/53 , C12N2320/51 , C12N2330/30 , Y02A50/393 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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8.发明公开RNA INTERFERENCE MEDIATED INHIBITION OF EPIDERMAL GROWTH FACTOR RECEPTOR GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) 审中-公开通过RNA干扰介导的受体的表皮生长因子基因表达使用siNA的抑制（短干扰核酸）
公开(公告)号：EP1501853A2
公开(公告)日：2005-02-02
申请号：EP03716093.4
申请日：2003-02-20
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/332 , C12N2310/53
摘要： The present invention concerns methods and reagents useful in modulating EGFR gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against HER1, HER2, HER3 and/or HER4. The small nucleic acid molecules are useful in the treatment and diagnosis of cancer.
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9.发明公开RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) 有权通过使用新浪基因表达的RNA干扰介导的抑制（短干扰核酸）
公开(公告)号：EP1423406A2
公开(公告)日：2004-06-02
申请号：EP03743684.7
申请日：2003-02-20
发明人： MCSWIGGEN, James , BEIGELMAN, Leonid , CHOWRIRA, Bharat , PAVCO, Pamela , FOSNAUGH, Kathy , JAMISON, Sharon , USMAN, Nassim , THOMPSON, James
CPC分类号： C12N15/8218 , A61K38/00 , A61K47/54 , C07H21/02 , C12N15/111 , C12N15/1131 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/315 , C12N2310/317 , C12N2310/318 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/344 , C12N2310/346 , C12N2310/53 , C12N2320/51 , C12N2330/30 , Y02A50/393 , C12N2310/3521
摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.
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