专利检索 ap:("SKYEPHARMA CANADA INC.") AND inv:"KRUKONIS, Val" 第 1 页

1.

发明授权
PROCESSES TO GENERATE PARTICLES OF WATER-INSOLUBLE COMPOUNDS OF UP TO 2000 NM IN SIZE 有权
标题翻译：新工艺颗粒制造水溶性成分的大小范围2000海里

公开(公告)号：EP1089714B1

公开(公告)日：2003-03-05

申请号：EP99930387.8

申请日：1999-06-18

申请人： SKYEPHARMA CANADA INC.

发明人： PACE, Gary, W. , VACHON, G., Michael , MISHRA, K., Awadhesh , HENRIKSEN, Inge, B. , KRUKONIS, Val , GODINAS, Anthony

IPC分类号： A61K9/16 , A61K9/51 , A61K9/14

CPC分类号： A61K9/1688 , A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , B01F3/1214 , B01F5/0287 , B01F2003/0064 , B01F2003/125 , B01F2215/0032 , B01J3/008 , Y10S977/773 , Y10S977/801 , Y10S977/906

摘要： Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.